Heterogeneity of Acid Phosphatase, β‐Glucuronidase, and α‐Naphthyl‐Acetate Esterase in Normal and Leukaemic Lymphocytes

Celiński, A; Pajdak, W

doi:10.1111/j.1600-0609.1977.tb02346.x

Cited by 6 publications

(1 citation statement)

References 16 publications

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“…With respect to leukaemic lymphoblasts, many iso-enzymes of ANAE have been described (Celinski & Pajdak 1977, Kass & Munster 1979. These may be more or less demonstrable by a single cytochemical technique.…”

Section: Discussionmentioning

confidence: 99%

Acetylesterase in Lymphoblastic Leukaemia Associated with Thymic Enlargement

Barr

Koekebakker

Cameron

et al. 1983

Scandinavian Journal of Haematology

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Focal cytoplasmic acetylesterase activity was sought in the malignant cells of 91 consecutive children with acute lymphoblastic leukaemia, of whom 10 had an anterior mediatstinal mass at diagnosis. This subgroup with thymic disease (TD) was characterized by hyperleucocytosis, the total leucocyte count being greater than 200 times 109/1 in 6 patients. Furthermore, there was a significant association (P < 0.025) between TD and the presence of leukaemic blast cells expressing a thymic phenotype, in the form of rosette formation with sheep erythrocytes. Focal cytoplasmic acetylesterase activity identified TD with a sensitivity of 20%, a specificity of 91 %, a positive predictive value of 25 %, a negative predictive value of 88 % and a diagnostic accuracy of 81%. The demonstration of this feature by a simple cytochemical technique can be a useful component of the profile of investigations which are employed in the classification of acute lymphoblastic leukaemia.

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Section: Discussionmentioning

confidence: 99%

Acetylesterase in Lymphoblastic Leukaemia Associated with Thymic Enlargement

Barr

Koekebakker

Cameron

et al. 1983

Scandinavian Journal of Haematology

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Analysis of acid esterase activity and polymorphism as an aid for the classification of human low-grade malignant Non-Hodgkin's lymphomas

Parwaresch

Staudinger

Radzun

1982

Cancer

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Investigating a link between enzyme histochemical and recent immunohistochemical results, the authors studied the activity and the polymorphism of acid esterase (EC 3.1.1.6) in well defined human B‐cell lymphomas. Twelve cases of chronic B‐lymphocytic leukemia, 18 cases of centroblastic/centrocytic follicular lymphoma, and 17 cases of lymphoplasmacytic/lymphoplasmacytoid lymphoma, as diagnosed according to Kiel classification, were subjected to enzyme assay and isoelectric focusing of acid esterase. Enzyme values revealed no characteristic distribution among the lymphoma entities. The isoenzyme pattern, specific to normal human B‐lymphocytes, were regularly detectable in all lymphoma entities. The results document the B‐cell origin of the analyzed subsets of B‐cell malignancies, although distinctive acid esterase patterns were lacking. The prevalence of three anodal isoenzymes in cases of chronic B‐lymphocytic leukemia, hardly detectable in other lymphoma entities, were interpreted as the expression of a clonal proliferation, arrested at a certain differentiation stage of B‐cells common for the majority of the tumor cells. Hence, further evidence is provided supporting the view that the studied entities represent B‐cell neoplasias at different stages of differentiation expressing a variety of different markers.

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Enzymes and Isozymes in Cancer

Balinsky

1980

Cancer Markers

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Heterogeneity of Acid Phosphatase, β‐Glucuronidase, and α‐Naphthyl‐Acetate Esterase in Normal and Leukaemic Lymphocytes

Cited by 6 publications

References 16 publications

Acetylesterase in Lymphoblastic Leukaemia Associated with Thymic Enlargement

Acetylesterase in Lymphoblastic Leukaemia Associated with Thymic Enlargement

Analysis of acid esterase activity and polymorphism as an aid for the classification of human low-grade malignant Non-Hodgkin's lymphomas

Enzymes and Isozymes in Cancer

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