Abstract:Modern single cell experiments have revealed unexpected heterogeneity in apparently functionally ‘pure’ cell populations. However, we are still lacking a conceptual framework to understand this heterogeneity. Here, we propose that cellular memories - the ability of individual cells to record their developmental past and adapt their response to their environment accordingly - are an essential ingredient in any such theory. We illustrate this idea by considering a simple age-structured model of stem cell prolife… Show more
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