Heterocyclic System Containing Bridgehead Nitrogen Atom: Synthesis and Pharmacological Activities of Some Substituted 1,2,4‐Triazolo[3,4‐b]‐1,3,4‐thiadiazoles.

Abstract

Substituted 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazoles. -Some of the title compounds (VI) (24 examples) show moderate antimicrobial activity against various bacterial and fungal strains. None of them, however, exhibit significant antiinflammatory and analgesic activities. -(MATHEW, V.; KESHAVAYYA*, J.; VAIDYA, V. P.; Eur.

Crystal structure of 6-(2-fluorophenyl)-3-phenyl-[1,2,4]-triazolo[3,4-b][1,3,4]thiadiazole, C15H9FN4S

“…The coordinates of the aromatic H atoms were idealized and re ned using a riding model (AFIX 43 option of the SHELX program [17]). thiadiazoles were reported to exhibit signi cant antibacterial [7][8][9][10], pesticidal [11], anticancer [12], anti-in ammatory, analgesic and anti-oxidant activities [13]. In continuation to a previous interest in the chemical synthesis of [ [14,15], we report herein the synthesis and the crystal structure of the title compound as potential bioactive agent.…”

1,3,4-Thiadiazole as Antimicrobial Agent: A Review

“…Most of the compounds showed activity comparable with that of the standard drug [15] . (20). They were screened for their antimicrobial activities.…”

Synthesis and Antimicrobial Studies of Some 4-(Substituted)-Ethanoylamino-3-Mercapto-5- (4-Substituted) Phenyl-1,2,4-Triazoles

“…It is evident that antimicrobial resistance is associated with an increase in mortality. 1 7-18, 2012 (June) antibacterial, antifungal, [2][3][4][5][6][7][8] antitubercular, 9,10 anticancer, 11 anti-tumor, 12 anti-inflammatory [13][14][15] , anticonvulsant, [16][17] urease inhibitor, 18 openers of Caactivated potassium (Maxi-K) channel, 19 tubulin polymerization inhibitors, 20 ghrelin receptor antagonist 21 and antiviral activities. 22 These findings prompted us to synthesize 4-(substituted) ethanoylamino-3-mercapto-5-(4-substituted) phenyl-1,2,4-triazoles 6-14a,b having substitution on aromatic ring and different secondary amino groups were attached on ethanoyl moiety and these compounds were evaluated for antimicrobial activity.…”