Heterobimetallic complexes containing Sn(IV) and Pd(II) with 4-(2-Hydroxyethyl)piperazine-1-carbodithioic acid: Synthesis, characterization and biological activities

Hussain, Shabbir; Ali, Saqib; Shahzadi, Saira; Shahid, Muhammad

doi:10.1080/23312009.2015.1029038

Cited by 20 publications

(8 citation statements)

References 36 publications

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“…Spectroscopic studies used to verify the chemical composition of products (as well as geometry of the complexes and molar conductance) indicated that the synthesized metal complexes were non-electrolytes in nature. The complexes, at 0.96 mM exhibited 80-98 % inhibition of ALPs [17]. Zn(II) complex was more active against the enzyme than OMZ, HQL and other complexes.…”

Section: Dpph Radical Scavenging Activitymentioning

confidence: 95%

“…The stock solution (100 μL in each dish) was put into Petri dishes and then allowed to attain room temperature. The microorganisms were cultured and incubated for 24 h at 37 °C (for bacterial cultures) and for 48 h at 28 °C (for fungal cultures) [17,18]. Zones of inhibition in specimen Petri dishes were measured in mm with venire caliper in mm.…”

Section: Antimicrobial Assaymentioning

confidence: 99%

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Synthesis, characterization and pharmacological evaluation of mixed ligand-metal complexes containing omeprazole and 8-hydroxyquinoline

Ahmad¹,

Khan²,

Munawar³

et al. 2017

Trop. J. Pharm Res

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Section: Dpph Radical Scavenging Activitymentioning

confidence: 95%

Section: Antimicrobial Assaymentioning

confidence: 99%

Synthesis, characterization and pharmacological evaluation of mixed ligand-metal complexes containing omeprazole and 8-hydroxyquinoline

Ahmad¹,

Khan²,

Munawar³

et al. 2017

Trop. J. Pharm Res

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“…The synthesis of compounds requires multiple steps depending on the availability of starting materials. , The ease of the synthesis is controlled by various factors. The synthetic accessibility score (SAS) is a measure of the ease with which a molecule can be synthesized.…”

Section: Resultsmentioning

confidence: 99%

Generation of Chemical Space of Compounds for Prostate Cancer Treatment: Biological Activity Prediction, Clustering, and Visualization of Chemical Space

Ishfaq,

Halawa,

Ahmad

et al. 2023

ACS Omega

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Designing molecules for pharmaceutical purposes has been a significant focus for several decades. The pursuit of novel drugs is an arduous and financially demanding undertaking. Nevertheless, the integration of computerassisted frameworks presents a swift avenue for designing and screening drug-like compounds. Within the context of this research, we introduce a comprehensive approach for the design and screening of compounds tailored to the treatment of prostate cancer. To forecast the biological activity of these compounds, we employed machine learning (ML) models. Additionally, an automated process involving the deconstruction and reconstruction of molecular building blocks leads to the generation of novel compounds. Subsequently, the ML models were utilized to predict the biological activity of the designed compounds, and the t-SNE method was employed to visualize the chemical space covered by the novel compounds. A meticulous selection process identified the most promising compounds, and their potential for synthesis was assessed, offering valuable guidance to experimental chemists in their investigative endeavors. Furthermore, fingerprint and heatmap analysis were conducted to evaluate the chemical similarity among the selected compounds. This multifaceted approach, encompassing predictive modeling, compound generation, visualization, and similarity assessment, underscores our commitment to refining the process of identifying potential candidates for further exploration in prostate cancer treatment.

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“…В этой связи аминоспирт N-(2-гидроксиэтил)пиперазин (НЕР) представляет интерес в качестве активного компонента в промышленных аминовых абсорбентах, так как, с одной стороны, обладает необходимыми физико-химическими свойствами, предъявляемыми к молекуле аминоспирта для использования в технологиях аминовой очистки, с другой -может непосредственно взаимодействовать с углекислым газом [1-6]. НЕР также находит применение в качестве сырья для получения поверхностно-активных веществ и фармацевтических препаратов [7][8][9][10][11][12][13].…”

Section: Currently the Main Methods For Producing N-(2-hydroxyethyl) unclassified

On Reactivity of Piperazine Aminogrups in Interaction With Ethylene Oxide

Demidova¹,

Potekhin²,

Demidov³

2020

IVKKT

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Currently, the main method for producing N-(2-hydroxyethyl) piperazine in industry is the cyclization of ethylene glycols and ethanolamines in the presence of ammonia and hydrogen. The main disadvantage of this method is the production of a wide range of products and, as a consequence, low selectivity for N-(2-hydroxyethyl) piperazine. In this work, the object of study is the piperazine hydroxyethylation reaction in the presence of an “inert” solvent under the reaction conditions, as the most selective way to obtain N-(2-hydroxyethyl) piperazine. The solvent molecule acts as a homogeneous catalyst of the acid type and is characterized by the presence of a mobile proton for opening the oxirane ring of ethylene oxide by the acid-base mechanism. There was studied the dependence of the yield of reaction products on the parameters of the process in the temperature range of 60 - 130 ° C; solvent concentration (water, methylcellosolve) 1 - 75% wt. and molar ratio of reagents (ethylene oxide / piperazine) 0.2 - 1. Analysis of the reaction mass by gas-liquid chromatography showed that the main by-product is N, N'-bis (2-hydroxyethyl) piperazine - the product of the hydroxyethylation of N-(2-hydroxyethyl ) piperazine in the second amino group. The hydroxyl group of hydroxyethylation products are formed in a negligible amount. It was found that the composition and concentration of the solvent, as well as the temperature regime of hydroxyethylation, do not significantly affect the selectivity of the process. It was shown that piperazine hydroxyethylation is described by the kinetics of series-parallel reactions. The results obtained in the study may be of interest for the development of piperazine hydroxyethylation process technology, in terms of simplifying the mathematical model of the reactor unit by excluding from the description factors that do not significantly affect the selectivity of the formation of N-(2-hydroxyethyl) piperazine.

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Heterobimetallic complexes containing Sn(IV) and Pd(II) with 4-(2-Hydroxyethyl)piperazine-1-carbodithioic acid: Synthesis, characterization and biological activities

Cited by 20 publications

References 36 publications

Synthesis, characterization and pharmacological evaluation of mixed ligand-metal complexes containing omeprazole and 8-hydroxyquinoline

Synthesis, characterization and pharmacological evaluation of mixed ligand-metal complexes containing omeprazole and 8-hydroxyquinoline

Generation of Chemical Space of Compounds for Prostate Cancer Treatment: Biological Activity Prediction, Clustering, and Visualization of Chemical Space

On Reactivity of Piperazine Aminogrups in Interaction With Ethylene Oxide

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