Het effect van ketoprofenbehandeling ter preventie van het postpartum dysgalactiasyndroom bij zeugen

Claeyé, E; Beek, Josine; Meyns, Tom; Maes, Dominiek

doi:10.21825/vdt.v84i3.16600

Cited by 10 publications

(10 citation statements)

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“…The authors concluded that lying passively may be one of the signs of pain and inflammation after parturition in young sows, and when treated with ketoprofen, pain and inflammation can be alleviated and therefore support the health of the dam. This is in line with later studies by Homedes et al (2014) and Claeyé et al (2015). Claeyé et al (2015) showed that healthy sows treated with ketoprofen (1 mg/kg im) within 12 h after parturition had a reduced rectal temperature by 0.43°C.…”

Section: Medical Interventions For Improving Reproductive Health Duri...supporting

confidence: 93%

“…This is in line with later studies by Homedes et al (2014) and Claeyé et al (2015). Claeyé et al (2015) showed that healthy sows treated with ketoprofen (1 mg/kg im) within 12 h after parturition had a reduced rectal temperature by 0.43°C. Homedes et al (2014) showed that healthy sows treated with ketoprofen (3 mg/kg im) within 12 h after parturition had a lower piglet mortality rate between Days 2 and 7 after farrowing and more piglets weaned per litter.…”

Section: Medical Interventions For Improving Reproductive Health Duri...supporting

confidence: 93%

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Reproductive health of the sow during puerperium

Björkman

Kauffold

Kaiser

2022

Molecular Reproduction Devel

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The modern hyperprolific sow is susceptible to metabolic disease and chronic inflammation. The most sensitive phase is parturition, when the sow experiences systemic inflammation and stress, and major changes in metabolism and endocrinology. Resolution of inflammation and stress needs to happen quickly to ensure good reproductive health during puerperium. If the sow fails to adapt to these changes, puerperal disease may occur. The economically most important puerperal disease complex is the postpartum dysgalactia syndrome (PPDS). Other puerperal diseases include infections of the urogenital tract. Diagnosis of PPDS and urogenital disease on‐farm is challenging but several diagnostic methods, including clinical examination, behavioral observations, ultrasonography and biomarkers are available. Ultrasonography is an excellent tool for monitoring the health of the urogenital tract, the mammary gland, and uterine involution and guide further diagnostic interventions. Biomarkers such as Chromogranin A, tumor necrosis factor‐α, and interleukin‐6 represent promising tools to monitor general health and the systemic state of inflammation and oxidative stress of the sow. Nonsteroidal anti‐inflammatory drugs, dopamine antagonists, and oxytocin are promising to address the symptoms of PPDS. Reducing of stress, improving nutrition and intestinal health, and supporting animal welfare‐friendly husbandry help in the prevention of PPDS.

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Section: Medical Interventions For Improving Reproductive Health Duri...supporting

confidence: 93%

Section: Medical Interventions For Improving Reproductive Health Duri...supporting

confidence: 93%

Reproductive health of the sow during puerperium

Björkman

Kauffold

Kaiser

2022

Molecular Reproduction Devel

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show abstract

“…The treated sows presented less constipation and feed refusal during lactation, but there was no effect on the weight gain of piglets from treated sows. This was confirmed by Claeyé et al , 56 who showed that in healthy sows, ketoprofen (1 mg/kg im) reduced rectal temperature by 0.43°C during the first 24 hours. There was no effect on weight gain or survival of the piglets.…”

Section: Parenterally Administered Nsaidssupporting

confidence: 58%

Use of non‐steroidal anti‐inflammatory drugs in porcine health management

2019

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ObjectiveTreatment of inflammation and pain management is an important topic in the welfare of pigs. It is very difficult for veterinary practitioners to choose the most appropriate product for a certain problem. This review aims to summarise and discuss the characteristics of different non-steroidal anti-inflammatory drugs (NSAIDs), as well as paracetamol and metamizole, available for pigs in the European Union.MethodsThe databases Pubmed, Google Scholar, CliniPharm CliniTox and European Medicines Agency were searched. Relevant terms (eg,‘meloxicam’, ‘fever’, ‘swine’, ‘pig’, ‘inflammation’, ‘castration’, ‘pain’) were used to search for original articles, reviews and books. Only peer-reviewed articles were used. References from studies were also analysed in order to find additional relevant studies.ConclusionStudies which have investigated the efficacy of NSAIDs for different conditions, using different treatment regimens, are scarce. Most studies focused on the efficacy of NSAID-related pain alleviation in piglet castration, as well as the anti-inflammatory potential of NSAIDs in experimental inflammation models. Little research has been carried out on the use of metamizole, tolfenamic acid, paracetamol and sodium salicylate and their effect in pigs.

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“…In the present study, PDS was mainly defined based on the appearance of the udder during the first 3 days postpartum. Postpartum dysgalactia syndrome is assessed according to the absence or presence of inflammation (reddening and swelling) and/or agalactia of at least one teat of the udder [ 28 ]. Thus, some sows that had high fever without any appearance of udder inflammation were not included.…”

Section: Discussionmentioning

confidence: 99%

Administration of ketoprofen in postpartum sows to control the incidence of post-parturient disorders and improve piglet survival rate

Jeeraphokhakul¹,

Theerakulpisut²,

Khampoomee³

et al. 2023

Anim Biosci

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Objective: Inflammation and pain management in postpartum hyperprolific sows is currently an important animal welfare issue in the swine industry. The present study investigates effects of ketoprofen treatment on the incidence of post-parturient disorders, feed intake, colostrum yield, piglet colostrum intake, colostrum immunoglobulin G (IgG) and piglet mortality rate during the first 3 days of postnatal life.Methods: In total, 61 Danish Landrace×Yorkshire crossbred sows and their offspring (n = 833) were included in the experiment. The sows were randomly distributed into two groups: i) control (n = 31), sows were treated with tolfenamic acid 2 mg per kg for 2 days postpartum; ii) ketoprofen (n = 30), sows were treated with ketoprofen 3 mg per kg for 2 days postpartum. The farrowing process of the sows was monitored for 24 h daily, and data associated with farrowing were collected. Piglet colostrum intake, sow colostrum yield and colostrum IgG were determined.Results: During the first 3 days postpartum, the incidence of sows that had fever did not differ between control and ketoprofen groups (51.6% and 56.7%, respectively, p = 0.692). Piglet colostrum intake did not differ between control and ketoprofen groups (p = 0.736). However, the proportions of piglets that had inadequate colostrum intake were 71.3%, 22.6%, and 5.4% in those with birth weights of <1.0 kg, 1.0 to 1.29 kg, and ≥1.30 kg, respectively (p<0.001). The piglet mortality rate did not differ between control and ketoprofen groups (p = 0.808).Conclusion: Administration of ketoprofen in postpartum sows for 2 days can control the evidence of post-parturient disorders in sows as effectively as the use of tolfenamic acid. No deleterious effect of ketoprofen was detected on sow colostrum yield, piglet colostrum intake and piglet mortality. Therefore, ketoprofen can be recommended as an alternative anti-inflammatory drug used in postpartum sows.

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Het effect van ketoprofenbehandeling ter preventie van het postpartum dysgalactiasyndroom bij zeugen

Cited by 10 publications

References 4 publications

Reproductive health of the sow during puerperium

Reproductive health of the sow during puerperium

Use of non‐steroidal anti‐inflammatory drugs in porcine health management

Administration of ketoprofen in postpartum sows to control the incidence of post-parturient disorders and improve piglet survival rate

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