Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats

Kamışlı, Suat; Çiftçi, Osman; Kaya, Kürşat; Çetin, Aslı; Kamışlı, Özden; Özcan, Cemal

doi:10.1177/0748233713483192

Cited by 47 publications

(27 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our data is in line with previous studies showing that hesperidin therapy could significantly attenuate ROS formation by reducing the levels of TBARS and restored antioxidant enzyme activity and GSH to physiological levels in the brain [47] and cultured PC12 cells [48]. Another study showed that hesperidin treatment could reduce stress-induced anxiety, impaired locomotor activity, and mitochondrial dysfunction in mice by modulating the nitrergic pathway [49].…”

Section: Discussionsupporting

confidence: 92%

Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease

Tamilselvam¹,

Braidy

Manivasagam³

et al. 2013

Oxidative Medicine and Cellular Longevity

137

View full text Add to dashboard Cite

Rotenone a widely used pesticide that inhibits mitochondrial complex I has been used to investigate the pathobiology of PD both in vitro and in vivo. Studies have shown that the neurotoxicity of rotenone may be related to its ability to generate reactive oxygen species (ROS), leading to neuronal apoptosis. The current study was carried out to investigate the neuroprotective effects of hesperidin, a citrus fruit flavanol, against rotenone-induced apoptosis in human neuroblastoma SK-N-SH cells. We assessed cell death, mitochondrial membrane potential, ROS generation, ATP levels, thiobarbituric acid reactive substances, reduced glutathione (GSH) levels, and the activity of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) using well established assays. Apoptosis was determined in normal, rotenone, and hesperidin treated cells, by measuring the protein expression of cytochrome c (cyt c), caspases 3 and 9, Bax, and Bcl-2 using the standard western blotting technique. The apoptosis in rotenone-induced SK-N-SH cells was accompanied by the loss of mitochondrial membrane potential, increased ROS generation, the depletion of GSH, enhanced activities of enzymatic antioxidants, upregulation of Bax, cyt c, and caspases 3 and 9, and downregulation of Bcl-2, which were attenuated in the presence of hesperidin. Our data suggests that hesperidin exerts its neuroprotective effect against rotenone due to its antioxidant, maintenance of mitochondrial function, and antiapoptotic properties in a neuroblastoma cell line.

show abstract

Section: Discussionsupporting

confidence: 92%

Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease

Tamilselvam¹,

Braidy

Manivasagam³

et al. 2013

Oxidative Medicine and Cellular Longevity

137

View full text Add to dashboard Cite

show abstract

“…Most synthetic anticancer agents have been associated with nephrotoxic [136,137], neurotoxic, cardiotoxic [138] and gonadotoxic [139,140] side effects. For this reason, the search for anti-cancer bioactive peptides from food sources has increased.…”

Section: Food-derived Bioactive Peptides and Human Healthmentioning

confidence: 99%

Bioactive Peptides

Daliri

Lee

2017

Foods

368

254

View full text Add to dashboard Cite

The increased consumer awareness of the health promoting effects of functional foods and nutraceuticals is the driving force of the functional food and nutraceutical market. Bioactive peptides are known for their high tissue affinity, specificity and efficiency in promoting health. For this reason, the search for food-derived bioactive peptides has increased exponentially. Over the years, many potential bioactive peptides from food have been documented; yet, obstacles such as the need to establish optimal conditions for industrial scale production and the absence of well-designed clinical trials to provide robust evidence for proving health claims continue to exist. Other important factors such as the possibility of allergenicity, cytotoxicity and the stability of the peptides during gastrointestinal digestion would need to be addressed. This review discusses our current knowledge on the health effects of food-derived bioactive peptides, their processing methods and challenges in their development.

show abstract

“…Hesperidin (4′-methoxy-7-Orutinosyl-3′, 5-dihydroxyflavanone), a flavanone glycoside, is profusely found in citrus fruits. Numerous studies have suggested that hesperidin shows its neuroprotective action in cerebral ischemia reperfusion injury, hypoxia-ischemic brain injury, Huntington disease, cisplatin-induced neurotoxicity, stroke, pentylenetetrazole (PTZ)-induced kindling, and associated cognitive dysfunction [20][21][22][23][24]. On the other hand, [1,4] dioxin-6-yl] chroman-4-one] is a polyphenolic flavonoid and the chief component of silymarin derived from the herb milk thistle (Silybum marianum).…”

Section: Introductionmentioning

confidence: 99%

Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and Inflammatory Cytokines Level in Mice Hippocampus

Jangra

Kasbe

Pandey

et al. 2015

Biol Trace Elem Res

View full text Add to dashboard Cite

Mounting evidence suggests that long-term aluminum exposure results in severe toxic effects, including neurobehavioral and neurochemical anomalies. The present study was performed to examine the neuroprotective potential of hesperidin and silibinin against aluminum chloride (AlCl3)-induced neurotoxicity in mice. AlCl3 (100 mg/kg/day) was injected daily through oral gavage for 42 days. Concomitantly, hesperidin (50 and 100 mg/kg/day, p.o.) and silibinin (100 and 200 mg/kg/day, p.o.) was administered for 42 days in different groups. The extent of cognitive impairment was assessed by Morris water maze and novel object recognition test on the 43rd day. Neurotoxicity was assessed by measuring oxido-nitrosative stress and proinflammatory cytokines in the hippocampus of mice. Six weeks treatment with AlCl3 caused cognitive impairment as indicated by an increase in the retention latency time and reduction in the percentage of recognition index. AlCl3-treated group showed oxido-nitrosative stress as indicated by increase in the level of lipid peroxidation, nitrite and depleted reduced glutathione, catalase activity in the hippocampus. Moreover, the chronic AlCl3 administration raised the proinflammatory cytokines (interleukin-1β and tumor necrosis factor-α) level and increased acetylcholinesterase activity and reduced the BDNF content in the hippocampus of AlCl3-treated animals. However, chronic treatment with hesperidin and silibinin at higher doses significantly ameliorated the AlCl3-induced cognitive impairment and hippocampal biochemical anomalies. The present study clearly indicated that hesperidin and silibinin exert neuroprotective effects against AlCl3-induced cognitive impairment and neurochemical changes. Amelioration of cognitive impairment may be attributed to the impediment of oxido-nitrosative stress and inflammation in the hippocampus.

show abstract

Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats

Cited by 47 publications

References 26 publications

Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease

Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease

Bioactive Peptides

Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and Inflammatory Cytokines Level in Mice Hippocampus

Contact Info

Product

Resources

About