Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers

Morand, Christine; Dubray, Claude; Milenković, Dragan; Lioger, Delphine; Martin, Jean; Scalbert, Augustin; Mazur, Andrzej

doi:10.3945/ajcn.110.004945

Cited by 373 publications

(365 citation statements)

References 48 publications

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“…This result is not surprising, since hesperidin, which is the main polyphenol in OJ, is known to be stable in regard to pasteurization treatment, with a retention factor estimated at 95% for pasteurized OJ [20] [21].…”

Section: Vitamin C Folate Polyphenol and Dietary Fibermentioning

confidence: 82%

Nutritional Composition of Orange Juice: A Comparative Study between French Commercial and Home-Made Juices

Chanson-Rollé¹,

Braesco²,

Chupin³

et al. 2016

FNS

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The study aimed to compare the nutritional composition of commercial and home-made orange juices with a fruit content of 100%, i.e., without dilution with water and without addition of sugars or any other sweeteners. Orange juice samples (n = 12 for both types of juice) were representative of the French market and of French consumers' habits as determined by a consumer survey. The results showed that both types of juices contained the same concentrations in total sugars and polyphenols and had low levels of dietary fiber (P > 0.05 for all parameters). Commercial orange juice contained less vitamin C (P = 0.035) and folate (P = 0.002) than home-made juice (15% and 27% less, respectively), probably owing to the vitamin degradation that may occur during industrial production (e.g., during pasteurization) and storage of commercial orange juice. The observed differences were of relatively small magnitude overall, however, and within the expected ranges for vitamin loss due to pasteurization and storage at ambient temperature. Indeed, commercial orange juice contained 85% of the vitamin C concentration measured in home-made juice, showing that vitamin C was well preserved in commercial juice. Another study with a larger number of samples would be needed to confirm these observations.

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Section: Vitamin C Folate Polyphenol and Dietary Fibermentioning

confidence: 82%

Nutritional Composition of Orange Juice: A Comparative Study between French Commercial and Home-Made Juices

Chanson-Rollé¹,

Braesco²,

Chupin³

et al. 2016

FNS

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“…Similarly, in overweight-obese subjects with metabolic syndrome traits in relation to apoE3 genotype who received 150 mg/day of quercetin for 5-6 weeks, the SBP was significantly reduced by 3.4 mmHg [Egert et al 2009[Egert et al , 2010. Recently, our research group showed that hesperidin, the major flavonoid in orange products, was highly involved in the BP-lowering effect induced by orange juice consumption [Morand et al 2011]. In this randomized crossover study with healthy volunteers, we found that 4-week consumption of orange juice (500 ml/day) as well as of control drink plus hesperidin resulted in a significantly lower DBP (−3.2 ± 1.5 mmHg and -5.5 ± 1.8 mmHg, respectively) compared with that measured after consumption of control drink plus placebo (p = 0.023) [Morand et al 2011].…”

Section: Blood Lipidsmentioning

confidence: 99%

“…Recently, our research group showed that hesperidin, the major flavonoid in orange products, was highly involved in the BP-lowering effect induced by orange juice consumption [Morand et al 2011]. In this randomized crossover study with healthy volunteers, we found that 4-week consumption of orange juice (500 ml/day) as well as of control drink plus hesperidin resulted in a significantly lower DBP (−3.2 ± 1.5 mmHg and -5.5 ± 1.8 mmHg, respectively) compared with that measured after consumption of control drink plus placebo (p = 0.023) [Morand et al 2011]. A recent clinical trial has also considered the putative antihypertensive action of dietary anthocyanins [Hassellund et al 2011].…”

Section: Blood Lipidsmentioning

confidence: 99%

“…First, citrus hesperidin when administered to healthy subjects (292 mg) or to patients with metabolic syndrome (500 mg) for 3-4 weeks significantly improved vascular reactivity [Morand et al 2011;Rizza et al 2011]. Our study also showed that the improved postprandial microvascular endothelial reactivity induced by hesperidin positively correlates to its plasma concentrations and that this flavonoid directly contributes to the vascular protective effect of orange juice [Morand et al 2011].Another recent trial has assessed the acute effect of resveratrol (30, 90 and 270 mg) in overweight/ obese individuals with mildly elevated BP [Wong et al 2010]. This study showed a significant dose effect of resveratrol on plasma resveratrol concentration and on FMD, which increased from 4.1 ± 0.8% (placebo) to 7.7 ± 1.5% after 270 mg resveratrol.…”

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confidence: 99%

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Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians

Habauzit¹,

Morand²

2011

Therapeutic Advances in Chronic Disease

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227

145

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Growing evidence suggests that polyphenols could be serious candidates to explain the protective effects of plant-derived foods and beverages. Based on current studies, a general consensus has been achieved to sustain the hypothesis that the specific intake of foods and beverages containing relatively high concentrations of flavonoids may play a meaningful role in reducing cardiovascular disease (CVD) risk through an improvement in vascular function and a modulation of inflammation. This review aims at providing an update on the effects of the consumption of polyphenols-rich foods on intermediate clinical markers of CVD in humans, namely cholesterolemia, blood pressure, endothelial function and platelet function. To date, on the basis of clinical studies, the demonstration is particularly convincing for flavonoids from cocoa-derived products and to a lesser extent for those of tea. While additional studies in this area are clearly needed, incorporating plant foods that are rich in flavanols in the diet of healthy individuals could help to reduce CVD risk. For flavonoids from fruits such as berries, pomegranate, grapes or citrus fruits and those from beverages such as red wine or coffee, the evidence is so far inconclusive. This is primarily due to the limited number and the weakness of experimental designs of the studies performed with these dietary sources. Future long-term well-designed investigations with polyphenols-rich foods but also with isolated phenolic compounds would provide valuable information to establish public health recommendations on polyphenols, taking into account both the nature of the compounds and the optimal dose, for cardiovascular health protection. Therapeutic Advances in Chronic Disease 3 (2) 88 http://taj.sagepub.com mediators. The early phase of atherosclerosis is characterized by the accumulation of cholesterol deposits in macrophages in the intima of the arteries. These foam cells can aggregate to form fatty streaks that progressively mature into a fibrous plaque which is a hallmark of established atherosclerosis. Fibrous plaque is covered by a connective tissue cap with embedded smooth muscle cells. If the plaque continues to grow, it gradually restricts the blood flow causing ischaemia. The clinically important complications of atheroma usually involve rupture of the fibrous cap, causing exposure of highly thrombogenic collagen and resulting intraluminal thrombus. Activated platelets trigger vasoconstriction and further propagation of the thrombus, which may result in total cease in blood flow, and subsequent clinical event. KeywordsEvidence from epidemiological studies indicates a positive association between reduction in the incidence of CVD and consumption of plant-based foods such as fruit and vegetables, nuts, whole grains, plant-derived beverages [Dauchet et al. 2005;Hu and Willett, 2002]. In 2009, Dauchet and collaborators offered a review on the evidence for a relationship between fruit and vegetable consumption and the occurrence of CVD events [Dauchet et a...

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“…Beta blockers reduce melatonin secretion [300] . Hesperidin significantly lowered DBP 3-4 mmHg (p < 0.02) and improved microvascular endothelial reactivity in 24 obese hypertensive male subjects in a randomized, controlled crossover study over 4 wk for each of three treatment groups consuming 500 mL of orange juice, hesperidin or placebo [301] . Pomegranate juice is rich in tannins and has numerous other properties that improve vascular health and reduces the SBP by 5%-12% [302,303] .…”

Section: Additional Compoundsmentioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers

Cited by 373 publications

References 48 publications

Nutritional Composition of Orange Juice: A Comparative Study between French Commercial and Home-Made Juices

Nutritional Composition of Orange Juice: A Comparative Study between French Commercial and Home-Made Juices

Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians

The role of nutrition and nutraceutical supplements in the treatment of hypertension

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