Hesperidin attenuates brain biochemical changes of irradiated rats

Said, Ussama Z.; Saada, Helen N.; Abdalla, Mohga S; Elsayed, Mahdy E.; Amin, Alshimaa M.

doi:10.3109/09553002.2012.694008

Cited by 26 publications

(18 citation statements)

References 34 publications

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“…The compounds in this case were also successfully detected with an HPLC method. Hesperidin or its aglycone hesperetin seems to be able to traverse the BBB and directly exerts their neuroprotective effect in the brain [ 55 – 57 ].…”

Section: Discussionmentioning

confidence: 99%

Honeybush Extracts (Cyclopia spp.) Rescue Mitochondrial Functions and Bioenergetics against Oxidative Injury

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Butterweck

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et al. 2020

Oxidative Medicine and Cellular Longevity

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Mitochondrial dysfunction plays a major role not only in the pathogenesis of many oxidative stress or age-related diseases such as neurodegenerative as well as mental disorders but also in normal aging. There is evidence that oxidative stress and mitochondrial dysfunction are the most upstream and common events in the pathomechanisms of neurodegeneration. Cyclopia species are endemic South African plants and some have a long tradition of use as herbal tea, known as honeybush tea. Extracts of the tea are gaining more scientific attention due to their phenolic composition. In the present study, we tested not only the in vitro mitochondria-enhancing properties of honeybush extracts under physiological conditions but also their ameliorative properties under oxidative stress situations. Hot water and ethanolic extracts of C. subternata, C. genistoides, and C. longifolia were investigated. Pretreatment of human neuroblastoma SH-SY5Y cells with honeybush extracts, at a concentration range of 0.1-1 ng/ml, had a beneficial effect on bioenergetics as it increased ATP production, respiration, and mitochondrial membrane potential (MMP) after 24 hours under physiological conditions. The aqueous extracts of C. subternata and C. genistoides, in particular, showed a protective effect by rescuing the bioenergetic and mitochondrial deficits under oxidative stress conditions (400 μM H2O2 for 3 hours). These findings indicate that honeybush extracts could constitute candidates for the prevention of oxidative stress with an impact on aging processes and age-related neurodegenerative disorders potentially leading to the development of a condition-specific nutraceutical.

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Section: Discussionmentioning

confidence: 99%

Honeybush Extracts (Cyclopia spp.) Rescue Mitochondrial Functions and Bioenergetics against Oxidative Injury

Agapouda

Butterweck

Hamburger

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Hsd and related compounds exhibited promising results in other animal inflammatory models as well (Jain and Parmar, 2011;Rotelli et al, 2003;Said et al, 2012;Xu et al, 2009;Yeh et al, 2007). In a comparative study performed by Rotelli et al (2003), the flavanones Hsd and Hst were the only effective flavonoids on neurogenic inflammation and were the most effective ones in subchronic evaluation.…”

Section: Other Animal Modelsmentioning

confidence: 95%

“…Hsd and related compounds exhibited promising results in other animal inflammatory models as well (Jain and Parmar, ; Rotelli et al ., ; Said et al ., ; Xu et al ., ; Yeh et al ., ). In a comparative study performed by Rotelli et al .…”

Section: Anti‐inflammatory Effectsmentioning

confidence: 99%

“…Although not effective on the disease symptoms in the mouse model of experimental autoimmune encephalomyelitis (EAE, an experimental model of multiple sclerosis) (Verbeek et al, 2005), orally administered Hsd could efficiently offset radiation-induced oxidative stress in the cerebral hemispheres (Said et al, 2012). The obtained results were probably attributed to the antioxidant activity and radical scavenging properties of Hsd in addition to its inhibitory effect on the superoxide-derived Fenton reaction and, most importantly, its ability to penetrate the blood brain barrier (Said et al, 2012).…”

Section: Other Animal Modelsmentioning

confidence: 99%

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Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

et al. 2014

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Inflammation and oxidative stress are two major causes of various life-threatening diseases. Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species that have numerous biological properties, particularly antioxidant and anti-inflammatory. New findings showed that the antioxidant activity of Hsd/Hst was not only limited to its radical scavenging activity, but it augmented the antioxidant cellular defenses via the ERK/Nrf2 signaling pathway as well. Various in vitro and in vivo studies have been conducted to evaluate Hsd, its metabolites, or its synthetic derivatives at reducing inflammatory targets including NF-κB, iNOS, and COX-2, and the markers of chronic inflammation. In this review, new findings regarding the molecular targets of Hsd and Hst in the reduction of oxidative stress are discussed. Also, in the anti-inflammatory section, we provide a summary of significant investigations concerning the mechanisms of action based on the studied inflammation models.

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“…The enzyme preferentially degrades benzylamine and phenylethylamine and targets a wide variety of specific neurotransmitters involved in the primary substrates of MAO in the brain, including epinephrine (EP), norepinephrine (NE), dopamine (DA), serotonin (5-HT), and β-phenylethylamine (PEA) (1,2). The unique position of MAO in modulating the function of a diverse series of specific neurotransmitters in association with various conditions, including mood disorders (3), anxiety and depression (4,5), schizophrenia (6), attention deficit hyperactivity disorder (7)(8)(9), migraine (10), sexual maturation (11) and neurodegenerative diseases (12), has attracted significant attention to the protein as a therapeutic target.…”

Section: Introductionmentioning

confidence: 99%

Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer’s disease (Review)

Cai

2014

Molecular Medicine Reports

165

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Abstract. Activated monoamine oxidase (MAO) has a critical role in the pathogenesis of Alzheimer's disease (AD), including the formation of amyloid plaques from amyloid β peptide (Aβ) production and accumulation, formation of neurofibrillary tangles, and cognitive impairment via the destruction of cholinergic neurons and disorder of the cholinergic system. Several studies have indicated that MAO inhibitors improve cognitive deficits and reverse Aβ pathology by modulating proteolytic cleavage of amyloid precursor protein and decreasing Aβ protein fragments. Thus, MAO inhibitors may be considered as promising therapeutic agents for AD.

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Hesperidin attenuates brain biochemical changes of irradiated rats

Abstract: It could be concluded that hesperidin might attenuate the severity of radiation-induced biochemical disorders in brain tissues.

Cited by 26 publications

References 34 publications

Honeybush Extracts (Cyclopia spp.) Rescue Mitochondrial Functions and Bioenergetics against Oxidative Injury

Honeybush Extracts (Cyclopia spp.) Rescue Mitochondrial Functions and Bioenergetics against Oxidative Injury

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer’s disease (Review)

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