Hesperidin attenuates altered redox homeostasis in an experimental hyperlipidaemic model of rat

Kumar, Raushan; Akhtar, Farhan; Rizvi, Syed Ibrahim

doi:10.1111/1440-1681.13221

Cited by 27 publications

(10 citation statements)

References 68 publications

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“…In this case, hesperidin did not play a significant preventive effect. This agrees with a study reporting that daily hesperidin supplementation (100 mg/kg BW) did not restore the higher IL-6 secretion induced by high-fat diet intake in Wistar rats [44]. Nevertheless, other studies show that crude polyphenols extracted from blossoms of Citrus aurantium L. var.…”

Section: Discussionsupporting

confidence: 91%

Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise

et al. 2020

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Intensive training and exhausting exercise can disrupt innate and acquired immunity. The flavanone hesperidin has shown immunomodulatory properties in physiological and some pathological conditions, and positive effects on exercise-induced oxidative stress. Nevertheless, it remains uncertain whether it also prevents exhausting exercise-induced immune alterations. The aim of this study was to establish the effect of oral hesperidin supplementation on the systemic immune system in rats following an intensive training and exhausting exercise. For this purpose, female Wistar rats were randomized into an intensive training group or a sedentary group. Intensive training was induced by running in a treadmill 5 days per week (including two exhausting tests) for five weeks. Throughout the training period, 200 mg/kg of hesperidin or vehicle was administered by oral gavage three times per week. At the end, blood, thymus, spleen and macrophages were collected before, immediately after and 24 h after an additional final exhaustion test. Hesperidin supplementation enhanced natural killer cell cytotoxicity and the proportion of phagocytic monocytes, attenuated the secretion of cytokines by stimulated macrophages, prevented the leukocytosis induced by exhaustion and increased the proportion of T helper cells in the thymus, blood and spleen. These results suggest that hesperidin can prevent exhausting exercise-induced immune alterations.

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Section: Discussionsupporting

confidence: 91%

Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise

et al. 2020

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“…This bioflavonoid exhibits antioxidant, anti-inflammatory, and antibacterial effects [ 14 , 15 ]. A recent study has demonstrated that hesperidin protected cells against redox imbalances [ 16 ]. In addition, hesperidin markedly reduces oxidative stress-induced inflammatory cytokine levels and apoptosis [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Hesperidin Exhibits Protective Effects against PM2.5-Mediated Mitochondrial Damage, Cell Cycle Arrest, and Cellular Senescence in Human HaCaT Keratinocytes

et al. 2022

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Particulate matter 2.5 (PM2.5) exposure can trigger adverse health outcomes in the human skin, such as skin aging, wrinkles, pigment spots, and atopic dermatitis. PM2.5 is associated with mitochondrial damage and the generation of reactive oxygen species (ROS). Hesperidin is a bioflavonoid that exhibits antioxidant and anti-inflammatory properties. This study aimed to determine the mechanism underlying the protective effect of hesperidin on human HaCaT keratinocytes against PM2.5-induced mitochondrial damage, cell cycle arrest, and cellular senescence. Human HaCaT keratinocytes were pre-treated with hesperidin and then treated with PM2.5. Hesperidin attenuated PM2.5-induced mitochondrial and DNA damage, G0/G1 cell cycle arrest, and SA-βGal activity, the protein levels of cell cycle regulators, and matrix metalloproteinases (MMPs). Moreover, treatment with a specific c-Jun N-terminal kinase (JNK) inhibitor, SP600125, along with hesperidin markedly restored PM2.5-induced cell cycle arrest and cellular senescence. In addition, hesperidin significantly reduced the activation of MMPs, including MMP-1, MMP-2, and MMP-9, by inhibiting the activation of activator protein 1. In conclusion, hesperidin ameliorates PM2.5-induced mitochondrial damage, cell cycle arrest, and cellular senescence in human HaCaT keratinocytes via the ROS/JNK pathway.

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“…Once isolated EVs from Citrus limon juice, we characterized flavonoids, limonoids and lipids, and we found that among the identified compounds, LEVs contain hesperidin and eriocitrin, two flavonoids with well‐recognized beneficial properties. 27 , 30 , 31 The great interest in their use as anti‐inflammatory agents is paralleled to studies aimed at encapsulating these natural compounds in lipid structures to increase their stability and availability. 43 , 44 , 45 Since EVs are naturally occurring nanoparticles, they may represent an advantage in transporting biomolecules to target cells.…”

Section: Discussionmentioning

confidence: 99%

“…LEVs possess a variety of flavonoids, such as eriocitrin, quercetin, vicenin-2, naringin, hesperidin and limonoids, like limonin. Most of these natural compounds exert beneficial roles, such as antiinflammatory, [26][27][28] anti-oxidant, 29,30 anti-cancer properties, [31][32][33][34] neuroprotective effects 35,36 and contrast obesity in mice. 37 The identification of flavonoids content in LEVs prompted us to investigate the role of LEVs in inflammatory models.…”

Section: Metabolomic Content Of Levsmentioning

confidence: 99%

Anti‐inflammatory properties of lemon‐derived extracellular vesicles are achieved through the inhibition of ERK/NF‐κB signalling pathways

Raimondo

Urzì

Meraviglia

et al. 2022

J Cellular Molecular Medi

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Chronic inflammation is associated with the occurrence of several diseases. However, the side effects of anti‐inflammatory drugs prompt the identification of new therapeutic strategies. Plant‐derived extracellular vesicles (PDEVs) are gaining increasing interest in the scientific community for their biological properties. We isolated PDEVs from the juice of Citrus limon L. (LEVs) and characterized their flavonoid, limonoid and lipid contents through reversed‐phase high‐performance liquid chromatography coupled to electrospray ionization quadrupole time‐of‐flight mass spectrometry (RP‐HPLC–ESI‐Q‐TOF‐MS). To investigate whether LEVs have a protective role on the inflammatory process, murine and primary human macrophages were pre‐treated with LEVs for 24 h and then were stimulated with lipopolysaccharide (LPS). We found that pre‐treatment with LEVs decreased gene and protein expression of pro‐inflammatory cytokines, such as IL‐6, IL1‐β and TNF‐α, and reduced the nuclear translocation and phosphorylation of NF‐κB in LPS‐stimulated murine macrophages. The inhibition of NF‐κB activation was associated with the reduction in ERK1‐2 phosphorylation. Furthermore, the ability of LEVs to decrease pro‐inflammatory cytokines and increase anti‐inflammatory molecules was confirmed ex vivo in human primary T lymphocytes. In conclusion, we demonstrated that LEVs exert anti‐inflammatory effects both in vitro and ex vivo by inhibiting the ERK1‐2/NF‐κB signalling pathway.

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Hesperidin attenuates altered redox homeostasis in an experimental hyperlipidaemic model of rat

Cited by 27 publications

References 68 publications

Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise

Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise

Hesperidin Exhibits Protective Effects against PM2.5-Mediated Mitochondrial Damage, Cell Cycle Arrest, and Cellular Senescence in Human HaCaT Keratinocytes

Anti‐inflammatory properties of lemon‐derived extracellular vesicles are achieved through the inhibition of ERK/NF‐κB signalling pathways

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