Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke

Raza, Syed Shadab; Khan, Mohammad Moshahid; Ahmad, Ajmal; Ashafaq, Mohammad; Khuwaja, Gulrana; Tabassum, Rizwana; Javed, Hayate; Siddiqui, Muhammad Shoaib; Safhi, Mohammed M.; Islam, Fakhrul

doi:10.1016/j.brainres.2011.08.047

Cited by 114 publications

(60 citation statements)

References 63 publications

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“…It is shown to control pathophysiological disturbances of brain excitability in drug abuse, migraine and epilepsy [14] by the virtue of its antioxidant, anti-inflammatory and antiapoptotic properties. The neuroprotective efficacy of Hes is attributed in neurodegenerative processes including Huntington's disease, cerebral ischemia/reperfusioninduced memory dysfunction and brain damage induced by stroke [15][16][17]. Viswanatha et al [18] reported the protective effect of Hes against various neurobehavioral alterations induced by immobilization-stress in mice.…”

Section: Introductionmentioning

confidence: 98%

RETRACTED ARTICLE: Neuroprotective Effect of Hesperidin on Aluminium Chloride Induced Alzheimer’s Disease in Wistar Rats

et al. 2015

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The present study was aimed to evaluate the protective effect of hesperidin (Hes) on aluminium chloride (AlCl3) induced neurobehavioral and pathological changes in Alzheimeric rats. Intraperitonial injection of AlCl3 (100 mg/kg body weight) for 60 days significantly elevated the levels of aluminium (Al), activity of acetylcholinesterase (AChE) and protein expressions of amyloid precursor protein (APP), β amyloid (Aβ 1-42), β and γ secretases as compared to control group in hippocampus and cortex of rat brain. Hes administration orally along with AlCl3 injection for 60 days, significantly revert the Al concentration, AChE activity and Aβ synthesis-related molecules in the studied brain regions. Our results showed that aluminum exposure was significantly reduced the spontaneous locomotor and exploratory activities in open field test and enhanced the learning and memory impairments in morris water maze test. The behavioral impairments caused by aluminum were significantly attenuated by Hes. The histopathological studies in the hippocampus and cortex of rat brain also supported that Hes (100 mg/kg) markedly reduced the toxicity of AlCl3 and preserved the normal histoarchitecture pattern of the hippocampus and cortex. From these results, it is concluded that hesperidin can reverse memory loss caused by aluminum intoxication through attenuating AChE activity and amyloidogenic pathway.

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Section: Introductionmentioning

confidence: 98%

RETRACTED ARTICLE: Neuroprotective Effect of Hesperidin on Aluminium Chloride Induced Alzheimer’s Disease in Wistar Rats

et al. 2015

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“…Sesamol treatment was able to restore the expression of apoptotic markers to normal levels and therefore prevent apoptosis from occurring. The anti-apoptotic activity of sesamol has been suggested by previous results (61,62).…”

Section: Discussionmentioning

confidence: 59%

Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury

Gao

Xie

Liu

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to evaluate the therapeutic potential of sesamol treatment on focal ischemia/reperfusion (I/R) injury in the rat brain. The results demonstrated that pretreatment with sesamol seven days prior to focal cerebral I/R injury had significant positive effects, including improvements in neurological deficits (P<0.05), and a reduction in malondialdehyde content and elevation of antioxidant levels (superoxide dismutase, glutathione and glutatione peroxidase; both P<0.05). Furthermore, levels of B cell lymphoma-2 (Bcl-2)-associated X protein and caspase-3 were significantly downregulated, whereas the level of Bcl-2 was effectively increased. Conversely, the mRNA expression of proinflammatory cytokines were significantly reduced in focal cerebral I/R injury rats upon sesamol intervention. Therefore, the beneficial effects of sesamol on cerebral I/R injury may be due to the reduction of oxidative stress, inhibition of apoptosis and inflammation. The findings of the present study suggest that sesamol supplementation may serve as potent adjuvant in the treatment of focal cerebral ischemia/reperfusion injury due to its neuroprotective effects.

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“…In animal studies, intake of hesperidin decreases infarct size in male Wistar rats after middle cerebral artery occlusion (72). In SHR rats, hesperidin causes a dose-dependent decrease in systolic blood pressure and improves endothelial dysfunction (91,92).…”

Section: E682mentioning

confidence: 99%

Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: therapeutic implications for diabetes and its cardiovascular complications

Munir

Chandrasekaran

Gao

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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Munir KM, Chandrasekaran S, Gao F, Quon MJ. Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: therapeutic implications for diabetes and its cardiovascular complications. Am J Physiol Endocrinol Metab 305: E679 -E686, 2013. First published July 30, 2013 doi:10.1152/ajpendo.00377.2013.-The rising epidemic of diabetes is a pressing issue in clinical medicine worldwide from both healthcare and economic perspectives. This is fueled by overwhelming increases in the incidence and prevalence of obesity. Obesity and diabetes are characterized by both insulin resistance and endothelial dysfunction that lead to substantial increases in cardiovascular morbidity and mortality. Reciprocal relationships between insulin resistance and endothelial dysfunction tightly link metabolic diseases including obesity and diabetes with their cardiovascular complications. Therefore, therapeutic approaches that target either insulin resistance or endothelial dysfunction alone are likely to simultaneously improve both metabolic and cardiovascular pathophysiology and disease outcomes. Moreover, combination therapies with agents targeting distinct mechanisms are likely to have additive or synergistic benefits. Conventional therapies for diabetes and its cardiovascular complications that are both safe and effective are insufficient to meet rising demand. Large, robust, epidemiologic studies demonstrate beneficial metabolic and cardiovascular health effects for many functional foods containing various polyphenols. However, precise molecular mechanisms of action for food polyphenols are largely unknown. Moreover, translation of these insights into effective clinical therapies has not been fully realized. Nevertheless, some functional foods are likely sources for safe and effective therapies and preventative strategies for metabolic diseases and their cardiovascular complications. In this review, we emphasize recent progress in elucidating molecular, cellular, and physiological actions of polyphenols from green tea (EGCG), cocoa (ECG), and citrus fruits (hesperedin) that are related to improving metabolic and cardiovascular pathophysiology. We also discuss a rigorous comprehensive approach to studying functional foods that is essential for developing novel, effective, and safe medications derived from functional foods that will complement existing conventional drugs. insulin resistance; endothelial dysfunction; functional foods; polyphenols OBESITY, PREDIABETES, METABOLIC SYNDROME, and diabetes are characterized by insulin resistance, endothelial dysfunction and resultant cardiovascular complications (38,39,45).

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Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke

Cited by 114 publications

References 63 publications

RETRACTED ARTICLE: Neuroprotective Effect of Hesperidin on Aluminium Chloride Induced Alzheimer’s Disease in Wistar Rats

RETRACTED ARTICLE: Neuroprotective Effect of Hesperidin on Aluminium Chloride Induced Alzheimer’s Disease in Wistar Rats

Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury

Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: therapeutic implications for diabetes and its cardiovascular complications

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