HESA-A Attenuates Hepatic Steatosis in NAFLD Rat Model Through the Suppression of SREBP-1c and NF-kβ

Efati, Majid; Khorrami, Mahmoud; Jangravi, Zohreh; Mahmoudabadi, Ali Zarei; Raeiszadeh, Mohammad; Sarshoori, Javad Raouf

doi:10.1007/s10989-019-09930-3

Cited by 2 publications

(4 citation statements)

References 41 publications

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“…It is reported that cell signaling proteins can be affected by ROS overproduction [48]. Changes in cell signaling proteins always associated with pathological conditions such as overproduction of proinflammatory cytokines, which is named cytokine storm [7,48]. In the following section, we discuss ROS-activated signaling pathways that involving in the cytokine storm and subsequent lung injury during SARS-CoV2 infection.…”

Section: Ros-mediated Cellular Signaling Induces Cytokine Storm Durin...mentioning

confidence: 99%

Section: Ros-mediated Cellular Signaling Induces Cytokine Storm Durin...mentioning

confidence: 99%

“…The NFκB is considered as a ROS dependent transcription factor, which plays a pivotal role in the activation of the innate immune system [48,49]. ROS-dependent activation of NF-κB triggers massive production of proinflammatory cytokines and chemokines, such as TNFα, IL-1, IL6, and IL8 [49].…”

Section: Ros and Nfκb Signaling Pathwaymentioning

confidence: 99%

“…There is a positive feedback loop between ROS generation and cytokines produced by NF-kB signaling pathway [48]. TNFα is one of the main proinflammatory factors which are secreted in response to SARA-CoV-2 infection [76].…”

Section: Proinflammatory Cytokines Can Trigger Ros Productionmentioning

confidence: 99%

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A vicious circle between oxidative stress and cytokine storm in acute respiratory distress syndrome pathogenesis at COVID-19 infection

Meftahi¹,

Bahari²,

Jangravi³

et al. 2021

Ukr.Biochem.J

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In early December 2019, the pandemic of coronavirus disease 2019 (COVID-19) began in Wuhan City, Hubei Province, China. Since then, it has propagated rapidly and turned into a major global crisis due to the high virus spreading. Acute respiratory distress syndrome (ARDS) is considered as a defining cause of the death cases. Cytokine storm and oxidative stress are the main players of ARDS development during respiratory virus infections. In this review, we discussed molecular mechanisms of a fatal vicious circle between oxidative stress and cytokine storm during COVID-19 infection. We also described how aging can inflame the vicious circle. Keywords: acute respiratory distress syndrome (ARDS), COVID-19, cytokine storm, oxidative stress

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Section: Ros-mediated Cellular Signaling Induces Cytokine Storm Durin...mentioning

confidence: 99%

Section: Ros-mediated Cellular Signaling Induces Cytokine Storm Durin...mentioning

confidence: 99%

Section: Ros and Nfκb Signaling Pathwaymentioning

confidence: 99%

Section: Proinflammatory Cytokines Can Trigger Ros Productionmentioning

confidence: 99%

See 2 more Smart Citations

A vicious circle between oxidative stress and cytokine storm in acute respiratory distress syndrome pathogenesis at COVID-19 infection

Meftahi¹,

Bahari²,

Jangravi³

et al. 2021

Ukr.Biochem.J

View full text Add to dashboard Cite

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Pharmacological mechanism of immunomodulatory agents for the treatment of severe cases of COVID-19 infection

et al. 2021

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Objective Coronavirus disease 2019 (COVID-19) is a world-wide pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To date, treatment of severe COVID-19 is far from clear. Therefore, it is urgent to develop an effective option for the treatment of patients with COVID-19. Most patients with severe COVID-19 exhibit markedly increased serum levels of pro-inflammatory cytokines, including interferon (IFN)-α, IFN-γ, and interleukin (IL)-1β. Immunotherapeutic strategies have an important role in the suppression of cytokine storm and respiratory failure in patients with COVID-19. Methods A systematic search in the literature was performed in PubMed, Scopus, Embase, Cochrane Library, Web of Science, as well as Google Scholar preprint database using all available MeSH terms for Coronavirus, SARS-CoV-2, anti-rheumatoid agents, COVID-19, cytokine storm, immunotherapeutic drugs, IFN, interleukin, JAK/STAT inhibitors, MCP, MIP, TNF. Results Here, we first review common complications of COVID-19 patients, particularly neurological symptoms. We next explain host immune responses against COVID-19 particles. Finally, we summarize the existing experimental and clinical immunotherapeutic strategies, particularly anti-rheumatoid agents and also plasma (with a high level of gamma globulin) therapy for severe COVID-19 patients. We discuss both their therapeutic effects and side effects that should be taken into consideration for their clinical application. Conclusion It is suggested that immunosuppressants, such as anti-rheumatoid drugs, could be considered as a potential approach for the treatment of cytokine storm in severe cases of COVID-19. One possible limitation of immunosuppressant therapy is their inhibitory effects on host anti-viral immune response. So, the appropriate timing of administration should be carefully considered.

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HESA-A Attenuates Hepatic Steatosis in NAFLD Rat Model Through the Suppression of SREBP-1c and NF-kβ

Cited by 2 publications

References 41 publications

A vicious circle between oxidative stress and cytokine storm in acute respiratory distress syndrome pathogenesis at COVID-19 infection

A vicious circle between oxidative stress and cytokine storm in acute respiratory distress syndrome pathogenesis at COVID-19 infection

Pharmacological mechanism of immunomodulatory agents for the treatment of severe cases of COVID-19 infection

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