“…Price and Schmitz (90) reported that cyclophosphamide was not effective in reactivating latent HSV in superior cervical ganglia. Blyth et al (10,11) found that cyclophosphamide treatment failed to increase the incidence of recurrent clinical disease in persistently infected mice.The rabbit model Rabbits have proven to be an excellent laboratory model for the study of acute and persistent HSV infection.Keratitis(68,69,94), uveitis(69), conjunctivitis(69), and encephalitis(73,74,120) were produced in rabbits following experimental inoculation of HSV-1. Following corneal inoculation, virus or virus-specific fluorescence was detected in the corneal epithelium, the trigeminal ganglia, and the brain stem(6,94,112).…”