Herpesviruses in periodontal diseases

Slots, Jørgen

doi:10.1111/j.1600-0757.2005.00109.x

Cited by 150 publications

(236 citation statements)

References 248 publications

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“…Such pathogens have been detected by various methods used to diagnose periodontal diseases and evaluate the effects of therapy. The culture method was widely adopted in clinical practice after Slots et al developed various selection media (18); however, only a small number of bacteria species can be cultured, and these are problematic with regard to detection rate. Because of their high sensitivity, PCR techniques may be useful in investigating actual bacterial populations in individual patients.…”

Section: Discussionmentioning

confidence: 99%

Use of quantitative PCR to evaluate methods of bacteria sampling in periodontal patients

Masunaga

Tsutae

et al. 2010

J Oral Sci

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Section: Discussionmentioning

confidence: 99%

Use of quantitative PCR to evaluate methods of bacteria sampling in periodontal patients

Masunaga

Tsutae

et al. 2010

J Oral Sci

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“…Other research has linked herpes virus to periodontal disease in marginal and apical periodontitis (Saygun et al 2008;Slots 2005). In other research, it has been associated with aggressive and chronic periodontitis (Bilichodmath et al, 2009;Botero et al, 2007;Contreras et al, 2000;Ling et al, 2004, Yapar et al, 2003Saygun et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Identification of Herpes virus in patients with chronic periodontitis from Northeastern Mexico

Mauricio¹,

Ernesto²,

Rosa³

et al. 2013

Afr. J. Microbiol. Res.

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Periodontitis is an inflammatory process that occurs in the tissues surrounding the teeth. It is caused by microorganisms and groups of microorganisms and results in loss of periodontal ligament and alveolar bone. Herpes virus has emerged as a putative pathogen in periodontal disease. Periodontal disease was demonstrated in 50 patients by careful probing of pockets and completion of a medical record. Three saliva samples were collected in individuals with deep pockets. Samples were obtained with a sterile swab and placed in 10% glucose solution for storage at -80°C. DNA purification and PCR, in addition to electrophoresis, were performed. Of the 50 samples processed, two were positive for HSV-1 and two for HSV-2. Three were from women with mild, moderate, and severe chronic periodontitis, respectively, and one (HSV-1) from a man with mild chronic periodontitis. Due to the low prevalence of herpes simplex virus in periodontal pockets, it was not possible to determine its role in the progression of periodontitis.

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“…This family of infectious agents is composed of three groups of viruses and has a distinct characteristic of being able to persist in latency and they depend on some stimulus for their reactivation, as occurs in cases of immunosuppression promoted by HIV infection. Herpesviruses have a single double-stranded deoxyribonucleic acid (DNA) molecule in their composition and notably, this group of viruses has been able to infect cells involved in human host [5][6] .…”

Section: Introductionmentioning

confidence: 99%

“…Herpesvirus 6 (HSV-6) causes sudden exanthema, as it regulates the expression of cluster of differentation (CD4), and it is associated to multiple sclerosis. Human herpesvirus 7 (HSV-7) is considered the etiologic agent of exanthema subitum, occurring primarily in children, and is accompanied by high fevers and rashes and the human herpesvirus type 8 (HSV-8) is associated with Kaposi's sarcoma and can cause death especially in immune suppressed patients [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

“…The human herpesvirus 3 (Varicella Zoster Virus -VZV) causes primary varicella, mainly in children and reinfection may be the cause of the herpes zoster (HZ). The human herpesvirus 4 (EBV) is associated with infectious mononucleosis, Burkitt's lymphoma and nasopharyngeal carcinoma [1][2][3][4][5][6] . The human herpes virus 5 (CMV) can cause pneumonia, rhinitis and severe hepatitis, particularly in individuals who have blood transfusions.…”

Section: Introductionmentioning

confidence: 99%

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Current status of herpesvirus identification in the oral cavity of HIV-infected children

Pinheiro

Ferreira

Costa

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Some viruses of the Herpesviridae family are frequently the etiologic agents of oral lesions associated with HIV. The aim of this study was to identify the presence of herpes simplex virus types 1 and 2 (HSV-1, HSV-2), Varicella Zoster virus (VZV), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), human herpesvirus type 6, type 7 and type 8 (HHV-6, HHV-7 and HHV-8) in the oral cavity of HIV-infected children/adolescents and verify the association between viral subtypes and clinical factors. Methods: The cells of oral mucosa were collected from 50 HIV infected children/adolescents, 3-13 years old (mean age 8.66). The majority (66%) of selected were girls, and they were all outpatients at the pediatric AIDS clinic of a public hospital in Rio de Janeiro. Nested-PCR was used to identify the viral types. Results: Absence of immunosuppression was observed in 66% of the children. Highly active antiretroviral therapy (HAART) was used by 72.1% of selected and moderate viral load was observed in 56% of the children/adolescents. Viral types were found in 86% of the children and the subtypes were: HSV-1 (4%), HSV-2 (2%), VZV (4%), EBV (0%), HCMV (24%), HHV6 (18%), HHV-7 (68%), HHV8 (0%). Conclusions: The use of HAART has helped to reduce oral lesions, especially with herpes virus infections. The health professionals who work with these patients should be aware of such lesions because of their predictive value and the herpes virus can be found circulating in the oral cavity without causing lesions.

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Herpesviruses in periodontal diseases

Cited by 150 publications

References 248 publications

Use of quantitative PCR to evaluate methods of bacteria sampling in periodontal patients

Use of quantitative PCR to evaluate methods of bacteria sampling in periodontal patients

Identification of Herpes virus in patients with chronic periodontitis from Northeastern Mexico

Current status of herpesvirus identification in the oral cavity of HIV-infected children

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