Identification of Herpes virus in patients with chronic periodontitis from Northeastern Mexico

Mauricio, Gonzalez Reyes; Ernesto, Torres Lopez; Rosa, Velia Ruiz Ramos; Claudio, Cabral Romero; Myriam, Angelica De La Garza Ramos

doi:10.5897/ajmr2013.6075

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…However, Mauricio et al . [ 18 ] have reported dubious role of herpesviruses in the severity of the chronic periodontitis as they have reported a very less prevalence rates in their study population.…”

Section: Discussionmentioning

confidence: 93%

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Role of herpesviruses in chronic periodontitis and their association with clinical parameters and in increasing severity of the disease

Kazi

Bharadwaj

2017

Eur J Dent

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Objective:This study aims to assess the role of herpesviruses in chronic periodontitis and their association with clinical parameters and in increasing severity.Materials and Methods:This was a prospective case–control study. Ethical approval and prior consent were taken. A subgingival plaque sample was collected from a total of 300 patients and 300 controls and processed for DNA extraction and multiplex polymerase chain reaction for detection of herpesviruses.Results:The most predominant age group affected was 41–50 followed by 31–40 years and male patients outnumbered the female patients. Herpes simplex virus (HSV)-1 (46.6%) was the most common Herpesvirus followed by HSV-2 (34.6%), Epstein–Barr viruses (EBV) (30.6%), and cytomegalovirus (CMV) (19.3%) in chronic periodontitis. Herpesviruses were significantly associated with increasing severity of the disease and had shown differences in their association with clinical parameters. Multiple herpesvirus infection was seen in patients with severe chronic periodontitis. The most common combination was HSV-1 + HSV-2 and HSV-1 + HSV-2 + EBV.Conclusions:HSV-1 was the most common herpesviruses implicated in the etiology of the chronic periodontitis followed by HSV-2, EBV and CMV. A herpesvirus differs in association with clinical parameters and plays an important role in increasing severity of the disease.

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Section: Discussionmentioning

confidence: 93%

“…Various studies have reported various prevalence rates (78.9% EBV by Bilichodmath et al .,[ 5 ] 32.0% by Das et al .,[ 16 ] 79.0% by Contreras and Slots[ 17 ] 32.0% by Mauricio et al . [ 18 ]) from patients with chronic periodontitis. The detection rates of the present study and Mauricio et al .…”

Section: Discussionmentioning

confidence: 99%

Role of herpesviruses in chronic periodontitis and their association with clinical parameters and in increasing severity of the disease

Kazi

Bharadwaj

2017

Eur J Dent

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“…Herpes viruses are thought to have an effect on the progression of periodontal disease. The results from some study [8,37,38] about that the presence of HSV1,HSV2,CMV, and EBV viruses in sub-gingival dental plaque suggest that the presence of (HSV1,HSV2,CMV, and EBV ) herpes viruses in sub-gingival dental plaque in patients with advanced stage of periodontal disease is significantly higher than their presence in sub-gingival dental plaque in patients with moderate stage of periodontal disease. The results of our study suggest that there is no significant difference in presence of viruses in supra-gingival plaque in patients with moderate and advanced stage of periodontal disease.…”

Section: Table 3 Induction Of Hsv-1 Hsv-2 Ebv and CMV Viruses Exprmentioning

confidence: 99%

MOLECULAR DETECTION OF VIRUS HERPES SIMPLEX TYPE 1(HSV-1) , VIRUS HERPES SIMPLEX TYPE 2(HSV-2), CYTOMEGALOVIRUS(HCMV) and EPSTEIN-BARRVIRUS (EBV) IN SUPRA-GI

Stojanoska¹,

Поповска²,

Anastasovska³

et al. 2018

KIJ

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Introduction Chronic periodontitis is as an inflammatory disease of the supporting tissue of the teeth caused by periopatogens microorganisams. New concept about etiology of periodontal disease suggests that herpes viruses may play an important role in the pathogenesis of periodontal disease. The aim of this study was to analyze the presence of herpes simplex virus type 1and 2 (HSV-1, HSV-2) cytomegalovirus (HCMV) and Epstein-Barr virus (EBV), in supra-gingival dental plaque .Materials and Methods The study comprised a total of 89 patients who were divided in two groups: patients who were diagnosed moderate stage of periodontal disease and patients who were diagnosed with advanced stage of periodontal disease. Clinical examinations included determination of plaque index, gingival index, sulcus bleeding index, probing depth, and clinical attachment level. Supra-gingival dental plaque samples were taken with sterile coton ball scrub on tooth enamel. Molecular detection of HSV1, HSV2 , EBV and CMV was analyzed using polymerase chain reaction (PCR).Results Molecular analysis of HSV-1 ,HSV-2, EBV and CMV in supra-gingival dental plaque in patients with chronic periodontal disease (a total of 89) showed the presence of EBV in 12,40% of patients , HSV-1 was found in 11,20% of patients, in 7,90% of patients was detected HSV-2, CMV was established in 9,00% of patients. In 3,40% patients in supra-gingival dental plaque was detected combination of viruses HSV1 and CMV, in 3,40% of patient combination of HSV1 and EBV ; and in 2,20% of patient combination ofHSV2,EBV was observed; in 2,20% of patients was found combination of 3 viruses HSV1; HSV2; EBV and in 49,50% patients we found negative finding. Patients with moderate stage of periodontal disease have a 0,78 times(OR = 0,78 / 0,33-1,84/)no significantly lower risk of probability of finding viruses in the supra-gingival plaque compared to patients who had advanced stage of periodontal disease. In the shown cross-culture of the presence of viruses in supra-gingival plaque in patients with moderate and advanced stage of periodontal disease for Fisher, s Exact Test = 5,19 and p >0.05 (p = 0.809 / Monte Carlo sig. (0.799-0.819)there is no significant difference.Conclusion We can associate the presence of herpes simplex viruses in supra-gingival dental plaque with periodontal disease. Our findings suggest that there is no significant difference in presence of viruses in supra-gingival plaque in patients with moderate and sereve stage of periodontal disease.

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Periodontal herpesviruses: prevalence, pathogenicity, systemic risk

Slots¹

2015

Periodontology 2000

112

164

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Periodontitis is an infectious/inflammatory disease characterized by the loss of periodontal ligament and alveolar bone. Herpesviruses are frequent inhabitants of periodontitis lesions, and the periodontopathogenicity of these viruses is the topic of this review. In 26 recent studies from 15 countries, subgingival cytomegalovirus, Epstein-Barr virus and herpes simplex virus type 1, respectively, yielded median prevalences of 49%, 45% and 63% in aggressive periodontitis, 40%, 32% and 45% in chronic periodontitis, and 3%, 7% and 12% in healthy periodontium. An active herpesvirus infection of the periodontium exhibits site specificity, is a potent stimulant of cellular immunity, may cause upgrowth of periodontopathic bacteria and tends to be related to disease-active periodontitis. Pro-inflammatory cytokines induced by the herpesvirus infection may activate matrix metalloproteinases and osteoclasts, leading to breakdown of the tooth-supportive tissues. The notion that a co-infection of herpesviruses and specific bacteria causes periodontitis provides a plausible etiopathogenic explanation for the disease. Moreover, herpesvirus virions from periodontal sites may dislodge into saliva or enter the systemic circulation and cause diseases beyond the periodontium. Periodontal treatment can diminish significantly the periodontal load of herpesviruses, which may lower the incidence and magnitude of herpesvirus dissemination within and between individuals, and subsequently the risk of acquiring a variety of medical diseases. Novel and more effective approaches to the prevention and treatment of periodontitis and related diseases may depend on a better understanding of the herpesvirus-bacteria-immune response axis.

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Identification of Herpes virus in patients with chronic periodontitis from Northeastern Mexico

Cited by 4 publications

References 20 publications

Role of herpesviruses in chronic periodontitis and their association with clinical parameters and in increasing severity of the disease

Role of herpesviruses in chronic periodontitis and their association with clinical parameters and in increasing severity of the disease

MOLECULAR DETECTION OF VIRUS HERPES SIMPLEX TYPE 1(HSV-1) , VIRUS HERPES SIMPLEX TYPE 2(HSV-2), CYTOMEGALOVIRUS(HCMV) and EPSTEIN-BARRVIRUS (EBV) IN SUPRA-GI

Periodontal herpesviruses: prevalence, pathogenicity, systemic risk

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