Herpesvirus infections of laboratory macaques

Simmons, Joe H.

doi:10.3109/15476910903409843

Cited by 9 publications

(3 citation statements)

References 92 publications

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“…Biologics have been documented to activate viruses of concern (17)(18)(19), and viral reactivation after immunosuppression has also been documented in nonhuman primates (49)(50)(51). To determine whether FR104 led to reactivation of latent viral pathogens, animals were assayed for the presence of herpesviruses, polyomaviruses, and HEV.…”

Section: Discussionmentioning

confidence: 99%

Selective Blockade of CD28-Mediated T Cell Costimulation Protects Rhesus Monkeys against Acute Fatal Experimental Autoimmune Encephalomyelitis

Haanstra

Dijkman

Bashir

et al. 2015

The Journal of Immunology

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Costimulatory and coinhibitory receptor–ligand pairs on T cells and APC control the immune response. We have investigated whether selective blockade of CD28–CD80/86 costimulatory interactions, which preserves the coinhibitory CTLA4–CD80/86 interactions and the function of regulatory T (Treg) cells, abrogates the induction of experimental autoimmune encephalomyelitis (EAE) in rhesus monkeys. EAE was induced by intracutaneous immunization with recombinant human myelin oligodendrocyte glycoprotein (rhMOG) in CFA on day 0. FR104 is a monovalent, PEGylated-humanized Fab′ Ab fragment against human CD28, cross-reactive with rhesus monkey CD28. FR104 or placebo was administered on days 0, 7, 14, and 21. FR104 levels remained high until the end of the study (day 42). Placebo-treated animals all developed clinical EAE between days 12 and 27. FR104-treated animals did not develop clinical EAE and were sacrificed at the end of the study resulting in a significantly prolonged survival. FR104 treatment diminished T and B cell responses against rhMOG, significantly reduced CNS inflammation and prevented demyelination. The inflammatory profile in the cerebrospinal fluid and brain material was also strongly reduced. Recrudescence of latent virus was investigated in blood, spleen, and brain. No differences between groups were observed for the β-herpesvirus CMV and the polyomaviruses SV40 and SA12. Cross-sectional measurement of lymphocryptovirus, the rhesus monkey EBV, demonstrated elevated levels in the blood of FR104-treated animals. Blocking rhesus monkey CD28 with FR104 mitigated autoreactive T and B cell activation and prevented CNS pathology in the rhMOG/CFA EAE model in rhesus monkeys.

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Section: Discussionmentioning

confidence: 99%

Selective Blockade of CD28-Mediated T Cell Costimulation Protects Rhesus Monkeys against Acute Fatal Experimental Autoimmune Encephalomyelitis

Haanstra

Dijkman

Bashir

et al. 2015

The Journal of Immunology

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“…Only macaque monkeys (e.g., rhesus, cynomolgus, and pig-tailed macaques) are known to naturally harbor B virus (Cohen et al, 2002). The virus persists latently in the trigeminal and lumbosacral ganglia of the macaque with occasional reactivation of viral shedding from peripheral sites in asymptomatic animals in response to physical or psychological stressors or during periods of immunosuppression (Estep et al, 2010;Simmons, 2010). The virus persists latently in the trigeminal and lumbosacral ganglia of the macaque with occasional reactivation of viral shedding from peripheral sites in asymptomatic animals in response to physical or psychological stressors or during periods of immunosuppression (Estep et al, 2010;Simmons, 2010).…”

Section: B Virus Infection (Macacine Herpesvirus 1)mentioning

confidence: 99%

Selected Zoonoses

Fox

Otto²,

Colby

2015

Laboratory Animal Medicine

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“…For the most informed path forward, it is important to understand the interaction between the infectious organism and the host immune system, as is discussed in the preceeding publications of presentations during the morning sessions (Hutto, 2010;Lerche, 2010;Price, 2010;Sasseville and Mansfield, 2010;Simmons, 2010;Taylor, 2010).…”

Section: Resultsmentioning

confidence: 99%