Herpes zoster in Hodgkin's disease.Clinical, histologic, and immunologic correlations

Abstract

In 163 consecutively irradiated patients with Hodgkin's disease, Stage I–III, herpes zoster subsequently occurred in 31 (19%). The incidence of zoster was increased in patients with mixed cellularity histology, Stage III disease, and in those patients with early stages treated with extensive irradiation. The majority of patients developed shingles within 6 months of primary treatment, a result suggestive of immunosuppression by lymphoma and/or irradiation, and was not associated with a high incidence of relapse. In those whose zoster occurred later than 6 months following primary therapy, a high incidence of lymphomatous recurrence (10/13) was noted, making herpes zoster an important prognosticator only in these selected individuals.

Robust gene expression changes in the ganglia following subclinical reactivation in rhesus macaques infected with simian varicella virus

“…The risk of getting HZ significantly increases with age, from an average of 3 cases per 1000 adults 40-50 years old, to 10 cases of HZ per 1000 adults aged ≥80 years (Keating, 2013). In addition, the incidence of HZ in individuals receiving immunosuppressive drugs such as those with autoimmune diseases, cancer, and organ transplant recipients is higher (Arvin, 2000; Rusthoven et al , 1988; Wilson et al , 1972; Yawn et al , 2011). VZV has also been shown to reactivate following stressful situations (Schmader et al , 1990), such as during and after spaceflight (Randall J. Cohrs, 2008) and in medical students (Uchakin et al , 2011).…”

Antibodies to Epstein‐Barr virus‐associated nuclear antigen and to other viral and non‐vical antigens in Hodgkin's Disease

“…Analysis of the data according to histological subtypes, shows that lymphocyte depletion is associated with the highest anti-EBNA antibody level and the lymphocyte predominance with the lowest. Anti-EBNA antibody seems, therefore, to behave in more or less the same way as other anti-EBV reactivities (Johansson et a/., 1970), since the highest anti-EBNA titers have been found with histological types associated, as a rule, with low-grade cellular immunity (Young et a[., 1972). The break-down, according to histologic type, of anti-VCA results also demonstrated that lymphocyte predominance was associated with relevant antibody Ievels, which significantly differed from those of controls, even though higher antibody reactivity was found among mixed cellularity and lymphocyte depletion types.…”

Herpes Zoster Vaccine for the Elderly: Boosting Immunity

“…Active hematologic malignancies significantly increase the risk for herpes zoster; for example, Hodgkin's lymphoma is associated with a 20% cumulative increase in risk [27]. The first year following allogeneic hematopoietic stem cell transplantation is associated with a 15–50% cumulative increase in risk [28].…”