Antibodies to Epstein‐Barr virus‐associated nuclear antigen and to other viral and non‐vical antigens in Hodgkin's Disease

Rocchi, G; Tosato, Giovanna; Papa, Guido; Ragona, Giuseppe

doi:10.1002/ijc.2910160216

Cited by 18 publications

(9 citation statements)

References 19 publications

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“…C-type RNA viruses have also been detected in tissues derived from Hodgkin's disease patients [16]. In addition, elevated antibody levels to Epstein-Barr virus (EBV) have been report ed in patients with Hodgkin's disease as compared to healthy subjects [9,17]. However, no EBV DNA could be detected in Hodgkin's disease tissues by DNA-DNA hybridization [18].…”

Section: Discussionmentioning

confidence: 99%

Detection of Mumps Virus Antigens in Hodgkin’s Disease Tissues

Truant¹,

Hallum²

1976

Oncology

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Mumps virus antigens were demonstrated in biopsied tissues from Hodgkin’s disease patients by indirect immunofluorescence. Impression smears from ten lymph node and two spleen specimens revealed viral antigens in the nucleus, cytoplasm or both. Measles virus antigens were detected in six out of seven Hodgkin’s disease tissues (lymph nodes) both in the nucleus and cytoplasm. All tissues tested for the presence of Newcastle diesease virus (NDV, an avian paramyxovirus) antigens were negative. Control tissues were obtained from patients with non-Hodgkin’s lymphomas, breast cancers, adenocarcinomas and a number of other disease processes. In control tissues mumps antigens were detected in seven out of 31 specimens and measles antigens in nine out of 18 tissues.

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Section: Discussionmentioning

confidence: 99%

Detection of Mumps Virus Antigens in Hodgkin’s Disease Tissues

Truant¹,

Hallum²

1976

Oncology

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“…Antibody studies also have been done to evaluate the relationship between EBV and HD. In studies of nearly 1,000 HD cases, the proportion with antibody to the viral capsid antigen (VCA), indicative of prior infection, has been quite similar to that of the controls Hirshaut et al, 1974;Goldman and Aisenberg, 1970;Levine et al, 1971;Carvalho et al, 1973;Langenhuysen et al, 1974;Rocchi et al, 1975). However, the cases have consistently had higher antibody titers.…”

Section: Biologic Considerationsmentioning

confidence: 98%

Epidemiology of Hodgkin's disease in the young

Gutensohn

Cole

1977

Intl Journal of Cancer

186

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Many features of Hodgkin's disease (HD) among adolescents and young adults suggest that it has an infectious etiology. However, the proposal that HD is a contagious disease which can be transmitted by patients or their close contacts has not been substantiated. An alternative infectious disease model is suggested by analogy with paralytic poliomyelitis (PP). For both diseases, the peak age of incidence is delayed as living conditions improve. For both, increased risk is associated with higher social class and small family size. Like PP, HD may be a rare manifestation of a common infection with the probability of disease development increasing as age at infection is delayed. This analogy is supported by the report that the risk of HD is higher for persons who had a low frequency of childhood infectious diseases. If this model is valid, HD patients represent no hazard to their contacts. However, the incidence of HD among young adults may increase in the coming decade because of the current high standard of living and small family size.

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“…Despite these positive findings, a large serological study of HL in young adults found no significant difference between the distributions of MV antibody titres in cases and controls. 23 A later casecontrol study of HL in young adults aged 15-24 years reported that the risk of developing HL was decreased in individuals with a past history of measles. 24 Case-control differences were significant for measles infection at all ages, measles infection at 5 years of age, and for non-EBV-associated cases (EBV2ve HL) compared to controls.…”

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confidence: 99%

Measles virus and classical Hodgkin lymphoma: No evidence for a direct association

Wilson

Freeland

Gallagher

et al. 2007

Intl Journal of Cancer

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A proportion of Hodgkin lymphoma (HL) cases are causally associated with the Epstein-Barr virus (EBV) but the aetiology of the remaining cases remains obscure. Over the last 3 decades several studies have found an association between HL and measles virus (MV) including a recent cohort study describing the detection of MV antigens in Hodgkin and Reed-Sternberg cells, the tumour cells in HL. In the present study we looked at the relationship between history of MV infection and risk of developing HL in a population-based, case/control study of HL. In addition we used immunohistochemistry and RT-PCR to look for direct evidence of MV in HL biopsies. There was no significant difference in the proportion of cases reporting previous measles compared to controls in the entire data set or when young adults were considered separately. Using a robust immunohistochemical assay for MV infection, we failed to find evidence of MV in biopsies from 97 cases of HL and RT-PCR studies similarly gave negative results. This study therefore provides no evidence that MV is directly involved in the development of HL. However, when age at first reported MV infection was investigated, significant differences emerged with children infected before school-age having higher risk, especially of EBV2ve HL, when compared with children infected at older ages; the interpretation of these latter results is unclear. ' 2007 Wiley-Liss, Inc.Key words: Hodgkin lymphoma; measles virus; PCR; epidemiology The term Hodgkin lymphoma (HL) encompasses 2 entities, nodular lymphocyte predominant HL and classical HL (cHL), which are now recognised as distinct disease processes.1 The pathology and epidemiology of cHL, which accounts for almost 95% of cases, also suggest that this is a heterogeneous entity that is likely to have more than one aetiology.2 Histologically, cHL is divided into 4 subtypes on the basis of the appearance of the rare tumour cells, the Hodgkin and Reed-Sternberg (HRS) cells, and the composition of the more plentiful background infiltrate.3 The most common subtypes are nodular sclerosis (NSHL) and mixed cellularity (MCHL).3 cHL generally shows a bimodal age-specific incidence curve but there is marked geographical variation in the shape of the curve and the age at which the incidence peaks occur. 4,5 It is the most common lymphoma in young adults in the Western world and the most common childhood malignancy in some developing countries.6,7 Epstein-Barr virus (EBV) is present in the HRS cells in a proportion of cHL cases and is believed to contribute to disease causation.8 EBV-associated cases (EBV1ve cHL) are not evenly distributed across all patient subgroups; cases of the MCHL subtype are more likely to be EBV-associated than NSHL cases, as are cases diagnosed in early childhood (<10 years) and older adulthood (>50 years).2 Consistent with this, a higher proportion of cases in developing countries are EBV-associated compared to developed countries, in which around 33% of cHL cases are EBV-positive. 9,10An increased risk of developing young...

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Antibodies to Epstein‐Barr virus‐associated nuclear antigen and to other viral and non‐vical antigens in Hodgkin's Disease

Cited by 18 publications

References 19 publications

Detection of Mumps Virus Antigens in Hodgkin’s Disease Tissues

Detection of Mumps Virus Antigens in Hodgkin’s Disease Tissues

Epidemiology of Hodgkin's disease in the young

Measles virus and classical Hodgkin lymphoma: No evidence for a direct association

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