Herpes zoster following inactivated COVID‐19 vaccine: A coexistence or coincidence?

Abstract

a straightforward relationship between herpes zoster and inactivated COVID-19 vaccine, immune dysregulation created by the vaccine may play a role in the reactivation of latent VZV infection in the current case. COVID-19 pandemic seems to be a favorable period for large-scale epidemiological studies to elucidate the relationship between the vaccination and herpes zoster reactivation due to planned massive vaccination.

A rare case of shingles after COVID-19 vaccine: is it a possible adverse effect?

“…To our knowledge this is the second VZV reactivation case after COVID 19 vaccination. First one was also reported from Turkey, 5 days after the COVID vaccination [ 19 ].…”

Pityriasis rosea after mRNA COVID‐19 vaccination

“…Several mechanisms may explain the PR/PR‐LE development after vaccination including mRNA COVID‐19 vaccine. Immune dysregulation may be induced by the vaccine‐specific infectious particles leading to HHV‐6/7 reactivation and typical PR eruption, akin to a recently reported herpes zoster virus reactivation in a patient receiving inactivated COVID‐19 vaccine 6 . Alternatively, vaccines may result in a delayed hypersensitivity response, similar to medication‐induced PR‐LE.…”

20 Post‐COVID‐19 vaccine‐related shingles cases seen at the Las Vegas Dermatology clinic and sent to us via social media

“…7 A suggested pathophysiologic mechanism involving angiotensin-signaling pathways has been posited as the etiology of filler-associated swelling; in fact, these patients have been successfully treated with angiotensin inhibitors. 12 The initial Pfizer vaccine application mentioned no reported adverse facial filler reactions with vaccination. 6 On 2/5/2021, the 1st case of Post-COVID-19 vaccine-related varicella-zoster virus (VZV) (Herpes Zoster (HZ) aka shingles) eruptions was seen in the Las Vegas Dermatology clinic and posted on our social media.…”

“…However, in the literature, there has been only one other reported case of Post-COVID-19 vaccine shingles in Turkey. 15…”