“…The writer has been impressed by the tendency of herpes zoster to affect nerves which already have been the site of injury—e.g., diabetic neuropathy, osteoporotic neuropathy, postoperative neuropathy, and areas of referred pain (such as the site of reflex sympathetic dystrophy following myocardial infarction.) Moreover, it has been postulated that pressure on, or involvement of ganglia by a neoplastic infiltrate (leukemia, lymphoma), a granulomatous process (tuberculous or syphilitic granuloma) or local trauma can serve as factors which determine the occurrence and localization of herpes zoster (21, 22). Perhaps dissemination of herpes zoster in certain systemic disorders such as chronic lymphatic leukemia (18) is as explainable on the basis of widespread nerve involvement as decreased immunologic resistance.…”