Herpes virus antibodies seroprevalence in children with autoimmune thyroid disease

Thomas, Dimitrios; Karachaliou, Feneli; Kallergi, K.; Vlachopapadopoulou, Elpis; Antonaki, Georgia; Chatzimarkou, Fotini; Fotinou, Aspasia; Kaldrymides, Philippos; Michalacos, Stefanos

doi:10.1007/s12020-008-9068-8

Cited by 24 publications

(15 citation statements)

References 21 publications

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“…Existing literature deals only with the detection of HHV-6 in the sera or tissue from patients with certain disease entities [10–14]. We detected HHV-6 IgG antibodies in 78.75% of blood donors, a seroprevalence similar to the one reported from other countries.…”

Section: Discussionsupporting

confidence: 70%

Seroprevalence of HHV-6 and HHV-8 among blood donors in Greece

Politou

Koutras

Kaparos

et al. 2014

Virol J

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BackgroundHerpes viruses infection transmitted through healthy but infected blood donors pose a danger to herpes-naive immunocompromised recipients. The risk of transfusion-related HHV-8 transmission is different in endemic and not endemic areas. HHV-6 and HHV-8 seroprevalence and viral load among blood donors have been reported from different countries. The aim of our study was to assess the seroprevalence of HHV-8 and HHV-6 in volunteer blood donors from Greece which is unknown.FindingsSerum samples from 179 healthy blood donors were tested for the presence of IgG antibodies against HHV-6 and HHV-8 with ELISA. None of the 179 donors of Greek origin tested was positive for HHV-8. HHV-6 seropositivity was assessed in 160 blood donors’ samples and was found to be 78.75% (126/160). The HHV-6 seroprevalence did not differ either between males and females or among different decade age groups.ConclusionsThe fact, that no blood donor was positive for HHV-8 IgG antibodies indicates that the risk for transfusion related HHV-8 transmission in Greece, if any, is negligible and does not warrant broad testing for HHV-8. Definitely further studies are needed, in order to clarify the potential risk of HHV-6 transmission.

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Section: Discussionsupporting

confidence: 70%

Seroprevalence of HHV-6 and HHV-8 among blood donors in Greece

Politou

Koutras

Kaparos

et al. 2014

Virol J

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“…However, evidence level remains low since the presence of enterovirus RNA in thyroid tissues did not correlate with both intrathyroidal lymphocytic infiltration and serum anti-TPO antibody [40]. Whereas an association of other viruses such as herpes viruses with AITD is suggested [41,42], their role in Hashimoto's thyroiditis development remains unknown [43].…”

Section: Viruses Implicated In the Cause Of Hashimoto's Thyroiditismentioning

confidence: 98%

Viral infection in induction of Hashimotoʼs thyroiditis: a key player or just a bystander?

Mori

Yoshida

2010

Current Opinion in Endocrinology, Diabetes and Obesity

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“…Infections have long been invoked as an underlying etiology or trigger for the induction of autoimmune thyroid diseases (1)(2)(3)(4). There is growing acceptance of a hygiene hypothesis which implies that the immune system is educated by multiple exposures to different infections allowing better controlled autoimmune responses (5,6).…”

Section: Introductionmentioning

confidence: 99%

Herpesvirus type 7 infection may play an important role in individuals with a genetic profile of susceptibility to Graves' disease

Leite

Bufalo²,

Santos³

et al. 2010

European Journal of Endocrinology

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Objective: An inherited profile of genes related to the response to aggressive environmental factors such as viruses and chemicals may be related to an increased susceptibility to Graves' disease (GD). Design and methods: This prospective case-control study was designed to examine the relationship between human herpesviruses (HHV) infection, determined by circulating DNA; tumour protein p53 (TP53) apoptotic ability; and detoxification system genes, and GD. We studied 280 confirmed GD patients paired to 284 controls with respect to environmental exposure. Exclusion criteria included medications that could interfere with thyroid function evaluation and a recent history of viral and bacterial infections. Results: A stepwise regression analysis adjusted for age, gender, and ethnicity established the inheritance of glutathione S-transferase pi 1 (GSTP1) (odds ratio (OR)Z3.423; 95% confidence interval (CI)Z2.120-5.527; P!0.001) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) variants (ORZ1.649; 95% CIZ1.012-2.686; PZ0.0445) as significant risk factors for the disease. HHV-7 infection was much more common in GD patients (64.64%) than in controls (38.73%; c 2 , P!0.0001), and it increased the risk for GD more than three times (ORZ3.133; 95% CIZ1.959-5.011; P!0.0001). The inheritance of less efficient Pro/Pro TP53 gene variants significantly increased the risk of GD development (ORZ5.196;; P!0.0001) and also favored HHV-7 infection (ORZ2.835; 95% CIZ1.100-7.310; PZ0.0275). In addition, 72TP53 variants augmented the risk of GD relapse (ORZ1.860; 95% CIZ1.015-3.410; PZ0.0446). Conclusions: We suggest that an inherited genetic profile involving TP53 may favor HHV-7 infection and maintenance, which, in turn, may initiate and perpetuate GD autoimmune process.

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Herpes virus antibodies seroprevalence in children with autoimmune thyroid disease

Abstract: EBV seroprevalence is higher in children with AITD compared to controls and the underlying pathology remains to be elucidated.

Cited by 24 publications

References 21 publications

Seroprevalence of HHV-6 and HHV-8 among blood donors in Greece

Seroprevalence of HHV-6 and HHV-8 among blood donors in Greece

Viral infection in induction of Hashimotoʼs thyroiditis: a key player or just a bystander?

Herpesvirus type 7 infection may play an important role in individuals with a genetic profile of susceptibility to Graves' disease

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