Herpes simplex virus type 1/adeno-associated virus hybrid vectors

Fraefel, Cornel; Heister, Thomas; Ackermann, Mathias

doi:10.1163/156855803762295404

gene ther regul

2003

DOI: 10.1163/156855803762295404

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Herpes simplex virus type 1/adeno-associated virus hybrid vectors

Cornel Fraefel¹,

Thomas Heister²,

Mathias Ackermann³

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2004

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“…Alphaherpesviruses commonly have a broad host range (10,19,40,43). Nevertheless, mice were hitherto assumed to be resistant to infection with either BHV-1 or BHV-5.…”

mentioning

confidence: 99%

Both Viral and Host Factors Contribute to Neurovirulence of Bovine Herpesviruses 1 and 5 in Interferon Receptor-Deficient Mice

Abril

Engels

Liman

et al. 2004

J Virol

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Herpes simplex virus (HSV) type 1 and bovine herpesviruses 1 and 5 (BHV-1 and BHV-5) can use the same cellular receptor for entry, but only HSV is known to cause disease in mice. We hypothesized that components of either the innate or the adaptive immune system, or a combination of both, were responsible for curbing replication of BHVs in mice. Therefore, wild-type mice as well as mice with various combined genetic deficiencies in the alpha/beta interferon receptor or gamma interferon receptor and in the ability to produce mature B and T lymphocytes (RAG-2 deletion) were infected with BHV-1 and BHV-5 and monitored clinically, serologically, histopathologically, and virologically. A functional immune system protected the mice from disease and death due to BHV infection, and the immune response was Th1 like. BHV-5 was transported to the central nervous system by the axonal pathway, whereas viremia was required for this outcome with BHV-1. The alpha/beta interferon system was able to obstruct quantitative spread of the viruses in the infected organism. The gamma interferon system had a protective effect against BHV-1, even in mice with the RAG-2 deletion. In contrast, the same mice succumbed to neurological disease and death upon infection with BHV-5. Productively infected neurons were detected only in BHV-5-infected mice with an intact gamma interferon system. We conclude that the alpha/beta interferon system had a protective effect, while an intact gamma interferon system was required for efficient replication of BHV-5 in mouse neurons and for the development of neurological disease.

show abstract

“…Alphaherpesviruses commonly have a broad host range (10,19,40,43). Nevertheless, mice were hitherto assumed to be resistant to infection with either BHV-1 or BHV-5.…”

mentioning

confidence: 99%

Both Viral and Host Factors Contribute to Neurovirulence of Bovine Herpesviruses 1 and 5 in Interferon Receptor-Deficient Mice

Abril

Engels

Liman

et al. 2004

J Virol

Self Cite

View full text Add to dashboard Cite

show abstract

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Herpes simplex virus type 1/adeno-associated virus hybrid vectors

Cited by 1 publication

References 51 publications

Both Viral and Host Factors Contribute to Neurovirulence of Bovine Herpesviruses 1 and 5 in Interferon Receptor-Deficient Mice

Both Viral and Host Factors Contribute to Neurovirulence of Bovine Herpesviruses 1 and 5 in Interferon Receptor-Deficient Mice

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