Herpes Simplex Virus Type 1 DNA in Cerebrospinal Fluid of a Patient with Mollaret's Meningitis

Yamamoto, Linda J.; Tedder, Davol G.; Ashley, Rhoda; Levin, Myron J.

doi:10.1056/nejm199110103251507

Cited by 102 publications

(25 citation statements)

References 27 publications

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“…Therefore, we assume that the viral DNA detected by PCR was that of HSV-1 and those that were negative could contain either HSV-2 or other viruses. Our findings are in agreement with previous reports [8,21,22,24] showing the efficacy of PCR methods in confirmation of possible involvement of HSV in such cases. Experiments to investigate the presence of nucleic acids of other neurotropic viruses are in progress.…”

Section: Discussionsupporting

confidence: 83%

Detection of Herpes Simplex Virus DNA in Cerebrospinal Fluid of Saudi Pediatric Patients with Encephalitis by the Polymerase Chain Reaction

Al‐Ahdal¹,

Kessie²,

Ahmed³

et al. 1993

Ann Saudi Med

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Section: Discussionsupporting

confidence: 83%

Detection of Herpes Simplex Virus DNA in Cerebrospinal Fluid of Saudi Pediatric Patients with Encephalitis by the Polymerase Chain Reaction

Al‐Ahdal¹,

Kessie²,

Ahmed³

et al. 1993

Ann Saudi Med

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“…Cryptococci were identified by a latex agglutination antigen test (Meridian Bioscience) and/or culture. PCR was performed if clinically indicated for enterovirus [17,18], herpes simplex virus [19], Neisseria meningitidis [20], and Mycobacterium tuberculosis (COBAS Amplicor MTB Test; Roche Diagnostics).…”

Section: Methodsmentioning

confidence: 99%

Proton Nuclear Magnetic Resonance--Based Metabonomics for Rapid Diagnosis of Meningitis and Ventriculitis

Coen

O’Sullivan

Bubb

et al. 2005

Clinical Infectious Diseases

105

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“…More modern technology using in situ hybridization and/or polymerase chain reaction (PCR) allows for the rapid detection of specific viral nucleic acid sequences in infected tissues and body fluids obtained from adults, children, and fetuses [5][6][7][8][9][10][11]. PCR is highly sensitive and has a low false-positive rate when performed concurrently with appropriate controls.…”

confidence: 99%

Detection of Viral Deoxyribonucleic Acid in Amniotic Fluid: Association with Fetal Malformation and Pregnancy Abnormalities

et al. 2005

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Objective: To first test the hypothesis that the presence of viral nucleic acid in amniotic fluid (AF) is associated with an abnormal pregnancy outcome, and second, to determine if the overall rate of polymerase chain reaction (PCR) positivity and the distribution of virus types vary geographically. Study Design: Cytomegalovirus (CMV), parvovirus B19, adenovirus, enterovirus, herpes simplex virus, Epstein-Barr virus, and respiratory syncytial virus nucleic acids were sought in 423 AF samples obtained for clinical indications: 284 from the East Coast (EC) and 139 from the Midwest (MW). Results: Gestational age at sampling was 19.1 weeks for EC and 20.1 weeks for MW. 13.5% of karyotypically normal singleton pregnancies (57/423) had a positive AF PCR. 11% of AF PCR from the EC while 18% of AF PCR from the MW were positive (p = 0.06). The most commonly detected viruses were adenovirus (77%), enterovirus (12%), and CMV and parvovirus B19 (5% each). Twenty-four percent of sonographically abnormal pregnancies (33/136) had a positive AF PCR compared to only 8.4% (24/287) of normal pregnancies (p < 0.001). Conclusion: A positive AF PCR is associated with an increased rate of fetal structural malformations, intrauterine growth restriction, hydrops and other fetal abnormalities. There were no significant geographic differences in the incidence of AF viral PCR positivity.

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Herpes Simplex Virus Type 1 DNA in Cerebrospinal Fluid of a Patient with Mollaret's Meningitis

Cited by 102 publications

References 27 publications

Detection of Herpes Simplex Virus DNA in Cerebrospinal Fluid of Saudi Pediatric Patients with Encephalitis by the Polymerase Chain Reaction

Detection of Herpes Simplex Virus DNA in Cerebrospinal Fluid of Saudi Pediatric Patients with Encephalitis by the Polymerase Chain Reaction

Proton Nuclear Magnetic Resonance--Based Metabonomics for Rapid Diagnosis of Meningitis and Ventriculitis

Detection of Viral Deoxyribonucleic Acid in Amniotic Fluid: Association with Fetal Malformation and Pregnancy Abnormalities

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