Herpes Simplex I virus impairs regenerative outcomes of periodontal regenerative therapy in intrabony defects. A pilot study

Bertoldi, Carlo; Pellacani, C.; Lalla, Michele; Consolo, Ugo; Cossarizza, Andrea

doi:10.1111/j.1600-051x.2012.01850.x

Cited by 17 publications

(20 citation statements)

References 51 publications

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“… showed that periodontal herpes simplex virus type 1 impaired clinical outcomes of regenerative therapy. The clinical attachment level improved by 5.9 ± 1.9 mm in herpes simplex virus type 1‐negative sites but only by 0.2 ± 1.8 mm in herpes simplex virus type 1‐positive sites, and gingival recession increased by 0.3 ± 0.7 mm in herpes simplex virus type 1‐negative sites but by as much as 3.0 ± 1.6 mm in herpes simplex virus type 1‐positive sites . Case reports have also related a herpes simplex virus type 1 infection to severe gingival inflammation and recession after muco‐gingival therapy .…”

Section: Disease Associationsmentioning

confidence: 99%

Periodontal herpesviruses: prevalence, pathogenicity, systemic risk

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2015

Periodontology 2000

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164

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Periodontitis is an infectious/inflammatory disease characterized by the loss of periodontal ligament and alveolar bone. Herpesviruses are frequent inhabitants of periodontitis lesions, and the periodontopathogenicity of these viruses is the topic of this review. In 26 recent studies from 15 countries, subgingival cytomegalovirus, Epstein-Barr virus and herpes simplex virus type 1, respectively, yielded median prevalences of 49%, 45% and 63% in aggressive periodontitis, 40%, 32% and 45% in chronic periodontitis, and 3%, 7% and 12% in healthy periodontium. An active herpesvirus infection of the periodontium exhibits site specificity, is a potent stimulant of cellular immunity, may cause upgrowth of periodontopathic bacteria and tends to be related to disease-active periodontitis. Pro-inflammatory cytokines induced by the herpesvirus infection may activate matrix metalloproteinases and osteoclasts, leading to breakdown of the tooth-supportive tissues. The notion that a co-infection of herpesviruses and specific bacteria causes periodontitis provides a plausible etiopathogenic explanation for the disease. Moreover, herpesvirus virions from periodontal sites may dislodge into saliva or enter the systemic circulation and cause diseases beyond the periodontium. Periodontal treatment can diminish significantly the periodontal load of herpesviruses, which may lower the incidence and magnitude of herpesvirus dissemination within and between individuals, and subsequently the risk of acquiring a variety of medical diseases. Novel and more effective approaches to the prevention and treatment of periodontitis and related diseases may depend on a better understanding of the herpesvirus-bacteria-immune response axis.

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Section: Disease Associationsmentioning

confidence: 99%

Periodontal herpesviruses: prevalence, pathogenicity, systemic risk

Slots¹

2015

Periodontology 2000

111

164

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“…However, the considerable heterogeneity of the literature on study populations, sample sizes, onset and duration of diabetes, level of glycemic control, and diagnosis of periodontal disease does not allow any easy discrimination. [27,[64][65][66][67] Chronic hyperglycemia is one of the key features of diabetes mellitus, but its effect on periodontal disease is much less known than the effects of diabetes, [19,68] particularly on the influence of IGT or IGF on periodontitis. Periodontal diseases can also play a role in cytokine mediation as an inflammatory condition.…”

Section: Number Of Cigarettes Per Daymentioning

confidence: 99%

Risk factors and socioeconomic condition effects on periodontal and dental health: A pilot study among adults over fifty years of age

et al. 2013

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Objective:Observational studies on the association among systemic/general and oral cavity indices, tooth loss, periodontal conditions, and socioeconomic inequalities are to be still performed in the population of Southern Europe. This study aims to determine the extent of this relationship among Italian healthy adults 50 years of age and above.Materials and Methods:Socioeconomic and lifestyle characteristics, cardiovascular indicators, and systemic indices were examined by contrasting the dental indices among adult people of Northern Italy. Data were processed through correlation analysis, and multivariate analysis was carried out using seemingly unrelated regressions.Results:A total of 118 adults 50 years of age and above, after anamnesis, underwent systemic and dental examination. Their socioeconomic status was found to be inversely associated only with smoking and dental parameters. Unexpected outcomes between lifestyle and risk factors were detected. The statistical analysis showed an uneven correlation among dental indices and between those indices and the socioeconomic status, such as, a periodontal condition, apparently free from influences, unusually became worse as the socioeconomic status enhanced.Conclusions:The study outcomes indicate a relationship between tooth loss and conservative endodontic therapy, but they result in alternative choices. Nevertheless, the socioeconomic status has an inverse relationship with tooth loss and conservative endodontic therapy, but a direct relation with worsening of the periodontal condition. This pilot study highlights a need for the public health administration to adopt a socioeconomic assessment not only based on the household income, but also to accordingly improve its therapeutic course.

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“…The connective tissue inflammation recorded resulted in significantly higher gingiva close to restorations than that in the gingiva close to the unrestored defects. In our study, we considered healthy patients, not suffering from periodontal disease (which is an inflammatory disease due to a systemic hindered control of inflammatory challenges), nonsmokers, with high compliance, to be subjected to a stringent supportive therapy (Bertoldi et al, 2012(Bertoldi et al, , 2013Page & Eke, 2007). The composite resin used was accurately managed, with respect to the preparation, bonding, high adaptation of margin, finishing and polishing, and also to control surface roughness.…”

Section: Discussionmentioning

confidence: 99%