Herpes gestationis: Clinical and histologic features of twenty-eight cases

Shornick, Jeff K.; Bangert, Jerry L.; Freeman, Robert G.; Gilliam, James N.

doi:10.1016/s0190-9622(83)70027-7

Cited by 188 publications

(144 citation statements)

References 14 publications

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“…The blister cavity typically contains fibrin, eosinophils, and neutrophils (2). Similar skin lesions are observed in the pregnancy-associated nonviral disorder, herpes gestationis (11).…”

Section: Introductionmentioning

confidence: 80%

A major role for neutrophils in experimental bullous pemphigoid.

Li¹,

Giudice²,

Zhou³

et al. 1997

J. Clin. Invest.

235

210

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Bullous pemphigoid (BP) is an inflammatory subepidermal blistering disease associated with an IgG autoimmune response to the hemidesmosomal protein, BP180. Using a passive transfer mouse model, our group has shown previously that antibodies to the murine BP180 (mBP180) ectodomain are capable of triggering a blistering skin disease that closely mimics human BP. In this study, we investigated the role of neutrophils in the immunopathogenesis of this disease model. BALB/c mice depleted of circulating neutrophils by treatment with neutrophil-specific antibodies were no longer susceptible to the pathogenic effects of anti-mBP180 IgG. IgG and complement were deposited at the dermalepidermal junction of these animals, but there was no evidence of inflammatory infiltration or blistering. C5-deficient mice, which are resistant to the pathogenic activity of antimBP180 IgG, could be made susceptible to this IgG-mediated blistering disease by intradermal administration of a neutrophil chemoattractant, IL-8 or C5a. Intraperitoneal injection of IL-8, which sequesters neutrophils in the peritoneal cavity, interferes with anti-mBP180-induced neutrophilic infiltration of the skin and prevented the development of BP disease in BALB/c mice. These findings provide the first direct evidence that neutrophils recruited to the skin via a C5-dependent pathway play an essential role in subepidermal blister formation in experimental BP, and suggest new directions for disease intervention. ( J.

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“…The blister cavity typically contains fibrin, eosinophils, and neutrophils (2). Similar skin lesions are observed in the pregnancy-associated nonviral disorder, herpes gestationis (11).…”

Section: Introductionmentioning

confidence: 80%

A major role for neutrophils in experimental bullous pemphigoid.

Li¹,

Giudice²,

Zhou³

et al. 1997

J. Clin. Invest.

235

210

View full text Add to dashboard Cite

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“…Herpes gestationis (HG)' is a rare, subepidermal bullous dermatosis of pregnancy and the postpartum period that characteristically begins in the second trimester and usually resolves within 3 mo after delivery (1,2). Immunopathologic features of the disease include linear deposition of C3 and, occasionally, IgG along the basement membrane zone (BMZ) of perilesional skin by direct immunofluorescence (IF), and, frequently, presence of a circulating IgG autoantibody directed against a BMZ antigen that avidly fixes complement (3,4).…”

Section: Introductionmentioning

confidence: 99%

Herpes gestationis autoantibodies recognize a 180-kD human epidermal antigen.

et al. 1988

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Herpes gestationis (HG) is a putative autoimmune bullous dermatosis of pregnancy which shares many findings with bullous pemphigoid (BP), a disease of the elderly. This study identifies for the first time the antigen detected by HG autoantibodies and compares it with that recognized by BP autoantibodies.Sera from 16 HG and 17 BP patients, and from normal pregnant women were evaluated by immunofluorescent (IF) studies and immunoblotted against human epidermal extracts. 89% of HG sera with circulating antibodies by IF recognized a 180-kD protein by immunoblotting. 71% of BP sera recognized a 240-kD band, but 47% detected a 180-kD protein that comigrated with the antigen detected by HG sera. None of the control sera recognized any specific bands.These findings suggest that the 180-kD epidermal protein may be the antigen detected by the HG factor and they also define immunologic similarities between HG and BP.

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“…Other histologic findings included dermal edema, mild perivascular inflammation with eosinophils, focal spongiosis, and epidermal ulceration. The histopathologic features of PG may vary greatly depending on the timing of the biopsy and the nature of the primary lesion [13][14][15]. Therefore, in many PG patients, nondiagnostic histologic findings are expected.…”

Section: Discussionmentioning

confidence: 99%