Heritability of factors of the insulin resistance syndrome in women twins

Edwards, Karen L.; Newman, Beth; Mayer, Elizabeth J.; Selby, Joe V.; Krauss, Ronald M.; Austin, Melissa A.

doi:10.1002/(sici)1098-2272(1997)14:3<241::aid-gepi3>3.0.co;2-8

Cited by 99 publications

(66 citation statements)

References 52 publications

(55 reference statements)

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“…29 By comparing female monozygotic and dizygotic twins, this lipid factor was shown to be heritable and possibly linked to both the lipoprotein lipase gene and the hormone-sensitive lipase gene. 30,31 Although the evidence supports common genetic influences on these cardiovascular risk factors, no study to date has simultaneously evaluated the genetic relationships among the 3 risk factors; LDL size, plasma TG, and HDL-C in high-risk families.…”

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confidence: 57%

Pleiotropic Genetic Effects on LDL Size, Plasma Triglyceride, and HDL Cholesterol in Families

Edwards

Mahaney

Motulsky

et al. 1999

ATVB

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Abstract-The interrelationships among low density lipoprotein (LDL) particle size, plasma triglyceride (TG), and high density lipoprotein cholesterol (HDL-C) are well established and may involve underlying genetic influences. This study evaluated common genetic effects on LDL size, TG, and HDL-C by using data from 85 kindreds participating in the Genetic Epidemiology of Hypertriglyceridemia (GET) Study. A multivariate, maximum likelihood-based approach to quantitative genetic analysis was used to estimate the additive effects of shared genes and shared, unmeasured nongenetic factors on variation in LDL size and in plasma levels of TG and HDL-C. A significant (PϽ0.001) proportion of the variance in each trait was attributable to the additive effects of genes. Maximum-likelihood estimates of heritability were 0.34 for LDL size, 0.41 for TG, and 0.54 for HDL-C. Significant (PϽ0.001) additive genetic correlations ( G ), indicative of the shared additive effects of genes on pairs of traits, were estimated between all 3 trait pairs: for LDL size and TG G ϭϪ0.87, for LDL size and HDL-C G ϭ0.65, and for HDL-C and TG G ϭϪ0.54. A similar pattern of significant environmental correlations between the 3 trait pairs was also observed. These results suggest that a large proportion of the well-documented correlations in LDL size, TG, and HDL-C are likely attributable to the influence of the same gene(s) in these families. That is, the gene(s) that may contribute to decreases in LDL size also contribute significantly to higher plasma levels of TG and lower plasma levels of HDL-C. These relationships may be useful in identifying genes responsible for the associations between these phenotypes and susceptibility to cardiovascular disease in these families.

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confidence: 57%

Pleiotropic Genetic Effects on LDL Size, Plasma Triglyceride, and HDL Cholesterol in Families

Edwards

Mahaney

Motulsky

et al. 1999

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“…Previous twin studies have also shown that phenotypic variation in most of the metabolic syndrome-related endophenotypes were largely genetic in origin [13,16,30]. Those studies also reported that common environmental variance shared by family members did not contribute to the variations of the endophenotypes.…”

Section: Discussionmentioning

confidence: 93%

“…The endophenotypes included: BMI; waist circumference; 0 (fasting), 30 [24] and HOMA of beta cell function [HOMA-%B] [25]). The BIGTT indices are new OGTT-derived indices of insulin sensitivity and beta cell function.…”

Section: Participantsmentioning

confidence: 99%

Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome?

et al. 2007

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Aims/hypothesis The cluster of obesity, insulin resistance, dyslipidaemia and hypertension, called the metabolic syndrome, has been suggested as a risk factor for cardiovascular disease and type 2 diabetes. The aim of the present study was to evaluate whether there are common genetic and environmental factors influencing this cluster in a general population of twin pairs. Materials and methods A multivariate genetic analysis was performed on nine endophenotypes associated with the metabolic syndrome from 625 adult twin pairs of the GEMINAKAR study of the Danish Twin Registry.Results All endophenotypes showed moderate to high heritability (0.31-0.69) and small common environmental variance (0.05-0.21). In general, genetic and phenotypic correlations between the endophenotypes were strong only within sets of physiologically similar endophenotypes, but weak to moderate for other pairs of endophenotypes. However, moderate correlations between insulin resistance indices and either obesity-related endophenotypes or triacylglycerol levels indicated that some common genetic backgrounds are shared between those components. Conclusions/interpretation We demonstrated that, in a general population, the endophenotypes associated with the metabolic syndrome apparently do not share a substantial common genetic or familial environmental background.

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“…Although it is well-known that insulin resistance plays a major role in the development of T2DM, the pathogenesis of T2DM is generally considered to result from the interactions between multiple susceptibility genes, as well as from interactions between genes and the environment (Edwards et al, 1997;Fu et al;Li et al, 2013). Transcription factor 7-like 2 (TCF7L2) is a Wnt signaling-associated transcription factor which is expressed in a board range of tissues including the gut and the pancreas.…”

Section: Introductionmentioning

confidence: 99%

Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population

Yang¹,

Yj²,

Liu³

2015

Genet. Mol. Res.

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ABSTRACT. Diabetes is one of costly chronic diseases. Previous studies across several ethnicities have shown that polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene were strongly associated with susceptibility to type 2 diabetes (T2DM). In the present study, the association between the TCF7L2 gene and the susceptibility to T2DM in a Chinese Hui population was interrogated. Polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis and allelic specific PCR were employed for examining the TCF7L2 gene rs12255372 (G>T) and rs290487 (C>T), and rs7901695 (T>C) polymorphisms, respectively, in 109 healthy individuals and 111 subjects with T2DM who were of Chinese Hui descent and lived in the Ningxia Hui Autonomous Region of China. The results showed that the genotypic frequency of rs290487 and the allelic frequency distributions of the rs7901695 and rs290487 loci were not significantly different between patients and controls in this population. However, both the genotypic and the allelic frequencies at rs12255372 exhibited statistical 10065 TCF7L2 gene polymorphisms and T2DM©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 10064-10071 (2015) differences between the patients with T2DM and the unaffected cohort (P < 0.01). In addition, the frequency of the G allele at the rs12255372 locus in the patients was higher than that in healthy individuals (OR = 1.198, 95%CI = 1.097-1.307). These findings suggest that the TCF7L2 rs12255372 (G>T) polymorphism might be one of the most important genetic factors associated with T2DM susceptibility, and that individuals in the Chinese Hui population who carry a G allele at this locus might be at risk to develop T2DM.

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Heritability of factors of the insulin resistance syndrome in women twins

Cited by 99 publications

References 52 publications

Pleiotropic Genetic Effects on LDL Size, Plasma Triglyceride, and HDL Cholesterol in Families

Pleiotropic Genetic Effects on LDL Size, Plasma Triglyceride, and HDL Cholesterol in Families

Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome?

Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population

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