Hereditary Prostate Cancer: Epidemiologic and Clinical Features

Clinical characteristics of African-American men with hereditary prostate cancer: the AAHPC study

“…However, neither study 17,22 reported the numbers of affected per family. Hence, these families may represent 'familial' cases vs 'hereditary' cases as defined by Carter et al 10 Schleutker et al 18 reported late age of onset in Finnish HPC families linked to the HPCX susceptibility locus.…”

“…This is the first large-scale study to describe the clinical characteristics of hereditary prostate cancer in affected African-American men from multiplex families. This elaborate multi-institutional network was designed to recruit African-American families that fulfill very stringent criteria for hereditary prostate cancer, exceeding those originally proposed by Carter et al 10 The AAHPC inclusion criteria were as follows: (a) African-American families with four or more members diagnosed with prostate cancer, (b) the combined age at diagnosis of all affected members in the family should average 65 y or less, (c) at least three affected members must donate a sample of blood for genotyping. These criteria differ from the original HPC definition proposed by Carter et al, 7,10 in which the hereditary subgroup consisted of three successive generations with prostate cancer, a clustering of three or more affected individuals in a nuclear family and/or two relatives with early onset (less than 55 y) of prostate cancer.…”

Role of genetic polymorphisms of the RNASEL gene on familial prostate cancer risk in a Japanese population

“…The numbers of affected family members were two out of 72 patients, three out of 14 patients and four out of 15 patients. In all, 29 patients with three or more affected family members were categorised into hereditary prostate cancer according to Carter's criteria (Carter et al, 1993). Prostate cancer was confirmed histologically at Gunma University Hospital and its affiliated hospitals.…”

“…Familial clustering of prostate cancer has been studied due to its clinical significance as a high-risk group of prostate cancer (Carter et al, 1992(Carter et al, , 1993 and its genetic significance as a biological model to identify susceptibility genes (Berthon et al, 1998;Berry et al, 2000;Bratt, 2000Bratt, , 2002. Six prostate cancer susceptibility loci (HPC1 at 1q24-25 (Smith et al, 1996), PCAP at 1q42-43 (Berthon et al, 1998), HPCX at Xq27-28 (Xu et al, 1998), CAPB at 1p36 (Gibbs et al, 1999), HPC20 at 20q13 (Berry et al, 2000) and HPC2 at 17p12 (Tavtigian et al, 2001)) and two candidate susceptibility genes (HPC2/ELAC2 at 17q (Tavtigian et al, 2001) and RNASEL at 1q24-25 ) have been reported.…”

Breast and prostate cancer

“…One specific form of hereditary prostate cancer is consistent with an autosomal dominant mode of inheritance in which it has been determined that the putative unknown locus might be responsible for about 9% of all prostate cancer cases (26). On the other hand, a family history of breast cancer increases the risk.…”