Clinical characteristics of African-American men with hereditary prostate cancer: the AAHPC study

Ahaghotu, Chiledum; Baffoe-Bonnie, Agnes; Kittles, Rick A.; Pettaway, Curtis A.; Powell, Isaac J.; Royal, Charmaine; Wang, H; Vijayakumar, Srinivasan; Bennett, James; Hoke, Gerald; Mason, Terry; Bailey-Wilson, Joan E.; Boykin, William; Berg, Kate; Carpten, John D.; Weinrich, Sally; Trent, Jeffrey M.; Dunston, Georgia M.; Collins, Francis S.

doi:10.1038/sj.pcan.4500719

Cited by 22 publications

(20 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, prostate cancer seems to have an inherited or genetic component (ACS, 2007c;Ahaghotu et al, 2004;Cooney, 1998;NCI, 2007;Nieder, Taneja, Zeegers, & Ostrer, 2003). One study (Carter et al, 1993) of 44,788 pairs of twins in the Scandinavian region examined the risk of cancers among monozygotic and dizygotic twins and found that the largest susceptibility to cancer accounted for by a genetic component was prostate cancer.…”

Section: Family Historymentioning

confidence: 96%

Reducing Prostate Cancer Morbidity and Mortality in African American Men: Issues and Challenges

Jones

Underwood

Rivers

2007

Clinical Journal of Oncology Nursing

View full text Add to dashboard Cite

Prostate cancer is the most commonly diagnosed cancer in men in the United States. It disproportionately affects African American men when compared to other ethnic groups. African American men are two to three times more likely to die of prostate cancer than white men. The reasons for the disparity remain unclear, but several factors may be involved, such as age, race, nationality, nutrition, exercise, and family history of cancer. Detection of prostate cancer in high-risk African Americans is important but continues to be controversial. This article reviews the current issues and challenges regarding prostate cancer in African American men. Nurses play a vital role in the health care and education of patients; therefore, they must be aware of the issues.

show abstract

Section: Family Historymentioning

confidence: 96%

Reducing Prostate Cancer Morbidity and Mortality in African American Men: Issues and Challenges

Jones

Underwood

Rivers

2007

Clinical Journal of Oncology Nursing

View full text Add to dashboard Cite

show abstract

“…[20][21][22] Ascertainment of multiplex PC families and the clinical description of the AA cases of HPC have been previously described. 20 21 Owing to barriers in recruiting AA men into HPC studies, the AAHPC Study Network developed a nationwide effort to establish collaborative recruitment centres in regions of the US with large numbers of AA including Atlanta, Chicago, Detroit, Harlem, Houston, rural South Carolina, and Washington.…”

Section: African American Hereditary Prostate Cancer Casesmentioning

confidence: 99%

A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history

Kittles

Boffoe-Bonnie

Moses

et al. 2006

Journal of Medical Genetics

View full text Add to dashboard Cite

Background: The EphB2 gene was recently implicated as a prostate cancer (PC) tumour suppressor gene, with somatic inactivating mutations occurring in ,10% of sporadic tumours. We evaluated the contribution of EphB2 to inherited PC susceptibility in African Americans (AA) by screening the gene for germline polymorphisms. Methods: Direct sequencing of the coding region of EphB2 was performed on 72 probands from the African American Hereditary Prostate Cancer Study (AAHPC). A case-control association analysis was then carried out using the AAHPC probands and an additional 183 cases of sporadic PC compared with 329 healthy AA male controls. In addition, we performed an ancestry adjusted association study where we adjusted for individual ancestry among all subjects, in order to rule out a spurious association due to population stratification. Results: Ten coding sequence variants were identified, including the K1019X (3055ART) nonsense mutation which was present in 15.3% of the AAHPC probands but only 1.7% of 231 European American (EA) control samples. We observed that the 3055ART mutation significantly increased risk for prostate cancer over twofold (Fisher's two sided test, p = 0.003). The T allele was significantly more common among AAHPC probands (15.3%) than among healthy AA male controls (5.2%) (odds ratio 3.31; 95% confidence interval 1.5 to 7.4; p = 0.008). The ancestry adjusted analyses confirmed the association. Conclusions: Our data show that the K1019X mutation in the EphB2 gene differs in frequency between AA and EA, is associated with increased risk for PC in AA men with a positive family history, and may be an important genetic risk factor for prostate cancer in AA.

show abstract

“…The report of linkage to chromosome 21 is based on a small number of AfricanAmerican families from the International Consortium for Prostate Cancer Genetics study and may therefore represent a spurious finding. It will be of great interest to see if a larger data set of African-American families replicates this finding (44).…”

Section: Meta-analysis For Finding Prostate Cancer Locimentioning

confidence: 99%

Genetic Susceptibility to Aggressive Prostate Cancer

Ostrander

Kwon

Stanford

2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Clinical characteristics of African-American men with hereditary prostate cancer: the AAHPC study

Cited by 22 publications

References 25 publications

Reducing Prostate Cancer Morbidity and Mortality in African American Men: Issues and Challenges

Reducing Prostate Cancer Morbidity and Mortality in African American Men: Issues and Challenges

A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history

Genetic Susceptibility to Aggressive Prostate Cancer

Contact Info

Product

Resources

About