Hereditary progressive retinal atrophy in the Abyssinian cat

Narfström, Kristina

doi:10.1093/oxfordjournals.jhered.a109782

Cited by 131 publications

(110 citation statements)

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“…Together, we present evidence that the IAA treatment produced an acute cat model of complete blindness that can be used for evaluation of visual function restoration or related experiments. Genetically modified feline model of photoreceptor degeneration has been developed for over the years [16][17][18][19][20][21]. However, one of the disadvantages of these animal models is the slow progress of the photoreceptor degeneration.…”

Section: Discussionmentioning

confidence: 99%

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Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat

Zhang

Ren

et al. 2013

Sci. China Life Sci.

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Iodoacetic acid (IAA) has been applied to different species to acutely induce photoreceptor degeneration. The purpose of the present study was to use this toxin to thoroughly eliminate photoreceptors and induce complete blindness in the cat. IAA was delivered by single ear vein injection (20 mg kg 1 ). Six months after the IAA treatment, functional evaluations including pupillary light reflex (PLR), electroretinogram (ERG), visual behavior tests were performed. Morphological examinations were carried out after the functional evaluation. The present result shows that, six months after the IAA application, animals lost visual functions and became completely blind. High dose IAA application via ear vein delivery created an acute and reliable complete photoreceptor degeneration model in the cat. This model can be applied to genetic and cellular therapies for visual function restoration.

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Section: Discussionmentioning

confidence: 99%

“…However, one of the disadvantages of these animal models is the slow progress of the photoreceptor degeneration. For instance, it could be developed over the period of 12-16 months [18,19] or up to four years [16,17]. Furthermore, one of the most inevitable drawbacks is the unpredictable disease status of the animal model.…”

Section: Discussionmentioning

confidence: 99%

Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat

Zhang

Ren

et al. 2013

Sci. China Life Sci.

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“…An ideal cat model for retinal degenerative disease is a strain of Abyssinian cats which has a slowly progressing retinal degeneration inherited by an autosomal recessive gene [91,[96][97][98] . Affected cats show characteristics similar to those in a human form of retinitis pigmentosa, and, thus, Abyssinian cats have become a useful research model for future treatment modalities in humans with retinal degeneration [91,[96][97][98][99][100][101] .…”

Section: Catsmentioning

confidence: 99%

“…Affected cats show characteristics similar to those in a human form of retinitis pigmentosa, and, thus, Abyssinian cats have become a useful research model for future treatment modalities in humans with retinal degeneration [91,[96][97][98][99][100][101] . During recent years, procedures for feline neuroretinal transplantation have been developed with the aim of restoring some function or rescuing degenerating photoreceptors in this Abyssinian cat mutant [90] .…”

Section: Catsmentioning

confidence: 99%

Retinal and Ocular Toxicity in Ocular Application of Drugs and Chemicals – Part I: Animal Models and Toxicity Assays

et al. 2010

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Aims: Experimental retinal research has gained great importance due to the ophthalmic pharmacotherapy era. An increasing number of drugs are constantly released into the market for the treatment of retinal diseases. In this review, animal species, animal models and toxicity assays in retinal research are discussed. Methods: An extensive search of the literature was performed to review various aspects of the methods of investigation of drug toxicity. The different types of animal species, as well as single animal models available for the evaluation of safety and efficacy of retinal pharmacotherapy, were identified. In addition, a large variety of reported laboratory techniques were critically examined. Results: In vitro studies are the first-line experiments for the development of a new drug for retinal diseases, using retinal pigment epithelial cells and other cell lines. The next step involves in vivo animal studies where nonhuman primates are considered the gold standard. However, cost and legal issues make their use difficult. Mice and rats provide genetically controlled models for investigations. Pigs, dogs and cats represent good large-size animal models, while rabbits are one of the most used species for retinal toxicity evaluations. Various laboratory methods were identified, including light microscopy, electron microscopy, electroretinography and new emerging methods, such as optical coherence tomography and scanning laser ophthalmoscopy for experimental purposes. Conclusions: A great number of animal species and models are available that simulate retinal diseases and provide experimental data for further human use. Work with animal models should include properly designed toxicity assays to obtain reliable results for safety and efficacy.

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“…These include naturally occurring inherited retinal degeneration in the chicken (12), cat (13), rat and mouse (14), and dog (15,16). Additionally, genetically engineered animal models such as mice (17), rats (18), and pigs (19) have provided opportunities to study retinal degeneration.…”

Section: Animal Studies and Somatic Gene Therapymentioning

confidence: 99%

Hereditary Degenerative Retinopathies: Optimism for Somatic Gene Therapy

Shastry

2000

IUBMB Life

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SummaryRetinitis pigmentosa comprises a large and exceptionally heterogeneous group of hereditary disorders of the retina. As a result of an extensive investigation around the world, primary genetic lesions have been described in many genes. Some of these genes encode enzymes that are involved in the signal transduction pathway. On the basis of in vitro functional assays and standard transgenic and knock-out experiments, it has been proposed that normal cell functions are disrupted because of an abnormal protein-folding and metabolic errors or structural defects in the membrane. This ultimately leads to a gene-mediated cell death known as apoptosis. Various gene transfer approaches using mouse models further suggest that the degeneration can be rescued to some extent. Although many questions remain to be answered, investigations during the last 10 years have enormously increased our understanding of this exceptionally heterogeneous disorder and give hope for an effective gene therapy and a possible cure. IUBMB Life, 49: 479 -484, 2000

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Hereditary progressive retinal atrophy in the Abyssinian cat

Cited by 131 publications

References 0 publications

Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat

Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat

Retinal and Ocular Toxicity in Ocular Application of Drugs and Chemicals – Part I: Animal Models and Toxicity Assays

Hereditary Degenerative Retinopathies: Optimism for Somatic Gene Therapy

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