Hereditary lymphosarcoma in a herd of pigs

Head, K. W.; Campbell, JG; Imlah, P.; Laing, AH; Linklater, KA; McTaggart, H.S.

doi:10.1136/vr.95.23.523

Cited by 23 publications

(11 citation statements)

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“…18 Evidence of hereditary transmission of multicentric lymphoma in domestic pigs via an autosomal recessive gene has been documented, although the only changes noted in the small intestine of those cases were increased prominence of ileal Peyer's patches. 5 Vietnamese potbellied pigs, first brought to the United States from Canada in 1986, are widely kept as pets and have an average life span of 12-18 years, with anecdotal evidence of pigs living as long as 21 years. The relatively short time they have been in North America and the increasing presence of aged pigs have resulted in a number of reports of newly described diseases in this breed.…”

Section: 8mentioning

confidence: 99%

Mucinous Adenocarcinoma and T-Cell Lymphoma in the Small Intestine of 2 Vietnamese Potbellied Pigs (Sus scrofa)

2010

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Small intestinal T-cell lymphoma and mucinous adenocarcinoma are rarely reported in the pig, with most lymphomas being of B-cell origin and only a single report of mucinous adenocarcinoma. Two aged Vietnamese potbellied pigs had concurrent T-cell lymphoma and mucinous adenocarcinoma of the small intestine. The lymphomas formed polypoid masses that projected into the intestinal lumen, whereas the mucinous adenocarcinomas were mural masses that bulged from the serosal surface. Immunohistochemically, neoplastic cells within the lymphomas were positive for CD3 and negative for CD79a. Mucicarmine stain highlighted the abundant cytoplasmic and extracellular mucin in the adenocarcinomas.

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Section: 8mentioning

confidence: 99%

Mucinous Adenocarcinoma and T-Cell Lymphoma in the Small Intestine of 2 Vietnamese Potbellied Pigs (Sus scrofa)

2010

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“…Similarly, a great number of lymphomas appeared in the offspring of a number of different sows that had been mated to the same boar and, in addition, there was a close kinship between the animals [4]. Such a widespread occurrence is due to the imbalance between the size of the populations of boars and sows.…”

Section: Discussionmentioning

confidence: 99%

“…Data on swine familial or hereditary lymphoma are available in few reports; in a herd, the occurrence of 53 cases of lymphoma in young pigs was associated with inbreeding [4], and in another report, two sows (dam and daughter) were affected with lymphoid neoplasms without splenomegaly and with prominent splenomegaly, respectively [20]. In contrast to these reports with no immunological information, a great number of thymic lymphomas found in the young female offspring of one bull were characterized by the expression of some B cell markers and terminal deoxynucleotidyl transferase (TdT), a marker for immature lymphocytes [2].…”

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confidence: 99%

Lymphoid Neoplasms in Swine

Ogihara

Ohba²,

Takai

et al. 2012

J. Vet. Med. Sci.

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ABSTRACT. Seventeen cases of lymphoid neoplasms in swine were investigated and divided into eight histological types. Cases 1-3 were precursor B lymphoblastic leukemias, which occurred in three piglets from the same dam. Cases 4 and 5 were diagnosed, respectively, as a precursor B lymphoblastic lymphoma and a thymic B cell lymphoma, because there were cytological differences between the lymphomas. These five cases of immature B cell malignancies expressed CD79a and terminal deoxynucleotidyl transferase (TdT). Mature B cell lymphomas were divisible into follicular (case 6), diffuse centroblastic (case 7) and intestinal large B cell (cases 8-11) lymphomas. Unlike in case 7, the neoplastic cells in cases 8-11 showed cytological features intermediate between centroblasts and immunoblasts. The mature lymphomas were characterized by positive immunolabeling for CD79a and cytoplasmic immunoglobulins. A case of thymic  T cell lymphoma (case 12) were positive for CD3, CD5, WC1 and TdT. Instead of TdT, perforin was expressed in  T cell lymphomas (cases 13-17), whose histological characteristics were epitheliotropism, homing into T cell zones of lymphatic tissues, and cytological atypia and pleomorphism. In the present study, lymphoid neoplasms could be classified into discrete histological types, some of which were considered to be specific for swine.

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“…This was impossible since affected animals never reached sexual maturity (33). Familial aggregation of melanomas, particularly in Sinclair miniature swine, but also in other breeds and their crosses led to selective breeding programmes.…”

Section: --Genetic Factorsmentioning

confidence: 99%

“…Unfortunately, no experimental matings could be arranged. A large-scale breeding programme indicated an autosomal recessive gene operating in the genesis of hereditary malignant lymphoma in Scotland (33,50).…”

Section: --Genetic Factorsmentioning

confidence: 99%

Congenital and hereditary tumours in domestic animals. 2. Pigs. A review

Misdorp

2003

Veterinary Quarterly

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Hereditary lymphosarcoma in a herd of pigs

Cited by 23 publications

References 0 publications

Mucinous Adenocarcinoma and T-Cell Lymphoma in the Small Intestine of 2 Vietnamese Potbellied Pigs (Sus scrofa)

Mucinous Adenocarcinoma and T-Cell Lymphoma in the Small Intestine of 2 Vietnamese Potbellied Pigs (Sus scrofa)

Lymphoid Neoplasms in Swine

Congenital and hereditary tumours in domestic animals. 2. Pigs. A review

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