Congenital and hereditary tumours in domestic animals. 2. Pigs. A review

Misdorp, W.

doi:10.1080/01652176.2003.9695141

Cited by 36 publications

(33 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dados de pesquisas realizadas em abatedouros de suínos em vários países (Misdorp 2003, Ogihara et al 2012 indicam que o linfoma é o neoplasma mais frequente nessa espécie. Na França, a taxa desse neoplasma tem sido estimada em 6,5 casos por 100.000 abates, chegando a aproximadamente 41% de todas as condenações relacionadas a neoplasmas (Jacobs et al 2002).…”

Section: Linfomaunclassified

“…Também chamado de nefroma embrionário, trata-se de um tumor congênito, originário de uma transformação neoplásica durante a nefrogênese (Meuten 2002, Misdorp 2003. É um neoplasma comum no suíno e reconhecido como o principal tumor primário renal da espécie, embora sua prevalência possa variar dependendo da região (Misdorp 2003, Grieco et al 2006.…”

Section: Nefroblastomaunclassified

“…Em um caso o neoplasma foi incriminado como a causa da morte do suíno, pois metástases eram observadas nos linfonodos, no pulmão, na parede torácica interna, no fígado e no útero. Apesar de na maioria dos casos ser considerado como um achado incidental de abatedouro, como os casos relatados, ocasionalmente os nefroblastomas podem adquirir grandes proporções, comprimindo órgãos da cavidade abdominal, e/ou adquirir componentes malignos, semelhante aos nefroblastomas em crianças, e metastatizar, principalmente para os linfonodos renais (Misdorp 2003, Grieco et al 2006.…”

Section: Nefroblastomaunclassified

“…Todas as lesões apresentavam superfície natural levemente irregular e brancacenta e, ao corte, eram firmes e homogeneamente branco-amareladas. As principais características macroscópicas descritas para o nefroblastoma são semelhantes às descritas na literatura (Meuten 2002, Misdorp 2003. Os mesmos autores citam ainda que, ocasionalmente, as massas podem ser difusas e em ambos os rins.…”

Section: Nefroblastomaunclassified

“…Apesar de alguns autores relatarem uma baixa prevalência deste neoplasma (Misdorp 2003, Martínez et al 2011a), suínos Duroc, Vietnamese pot-bellied pigs e algumas raças miniaturas são reconhecidas como predispostas geneticamente para o desenvolvimento de melanomas congênitos, apresentando incidência aumentada (Pérez et al 2002, Misdorp 2003, Okomo-Adhiambo 2012. Sua forma benigna (melanocitoma) também é comumente descrita em suínos (Goldschmidt & Hendrick 2002, Pérez et al 2002.…”

Section: Melanomaunclassified

See 4 more Smart Citations

Neoplasmas em suínos: 37 casos

et al. 2015

View full text Add to dashboard Cite

Neoplasms in swine are rare. This paper describes neoplasms found in swine in the diagnostic routine of a veterinary pathology laboratory in the Central Region of Rio Grande do Sul, Brazil during a 49-year period, during which 2,266 cases of the various affections in swine were diagnosed. Of those 37 cases (1.6%) were neoplasms. In decreasing order of prevalence, the following neoplasms were found: lymphoma (11 out of 37 cases), nephroblastoma (11/37), melanoma (8/37), and papilloma (2/37). Adenoma hepatocelular, carcinoma hepatocelular, cholangiocarcinoma, malignant fibrous histiocytoma, granulocytic sarcoma were each found in one case out of the 37 cases. The gross and histological aspects of these tumors are described and their epidemiology is compared with the data available in the literature for neoplasia in swine.

show abstract

Section: Linfomaunclassified

Section: Nefroblastomaunclassified

Section: Melanomaunclassified

See 3 more Smart Citations

Neoplasmas em suínos: 37 casos

et al. 2015

View full text Add to dashboard Cite

show abstract

A large preclinical animal model to assess ex vivo skin gene therapy applications

et al. 2006

View full text Add to dashboard Cite

Because of its easy accessibility, the skin is a very attractive target for gene therapy purposes. To study potential clinical applications in a preclinical setting, appropriate animal models are needed. Pig skin is very similar to human skin, and a variety of human diseases that are potentially amenable to gene therapy applications also occur in pigs. Only a few studies have analyzed the engraftment of transduced keratinocytes (KC) in pigs, however, with limited success. We describe a porcine model in which pig KC were transduced ex vivo with a retroviral vector encoding a marker gene and subsequently grafted onto the autologous host, utilizing a relatively simple grafting technique. Enhanced transduction efficiency was achieved by an optimized transduction protocol including centrifugation of the retroviral vector at a temperature of 32 degrees C. Transduced KC were then seeded onto acellular dermis, forming a stratified epidermis. Grafting was performed by creating full thickness wounds and placing the skin graft onto the muscle fascia, covered by a protective skin flap for several days. Successful engraftment of transduced KC was demonstrated by immunohistochemistry of biopsies taken at different time points, showing transgene expression in 40-50% of grafted KC. After 4 weeks, KC expressing a foreign marker gene was lost, suggesting a transgene-specific immune response in the immunocompetent pigs and highlighting the potential problems for clinical gene therapy studies when transferring new genetic material into a patient. The model presented here may be used to examine applications of skin gene therapy, where retroviral vectors encoding endogenous pig genes will be expressed in the skin.

show abstract

Illegitimate recombination between T cell receptor genes in humans and pigs (Sus scrofa domestica)

et al. 2014

View full text Add to dashboard Cite

T cell receptor (TCR) genes (TRA/TRD, TRB and TRG) reside in three regions on human chromosomes (14q11.2, 7q34 and 7p14, respectively) and pig chromosomes (7q15.3-q21, 18q11.3-q12 and 9q21-22, respectively). During the maturation of T cells, TCR genes are rearranged by site-specific recombination. Occasionally, interlocus recombination of different TCR genes takes place, resulting in chromosome rearrangements. It has been suggested that the absolute number of these "innocent" trans-rearrangements correlates with the risk of lymphoma. The aims of this work were to assess the frequencies of rearrangements with breakpoints in TCR genes in domestic pig lymphocytes and to compare these with the frequencies of corresponding rearrangements in human lymphocytes by using fluorescence in situ hybridization with chromosome painting probes. We show that frequencies of trans-rearrangements involving TRA/TRD locus in pigs are significantly higher than the frequency of translocations with breakpoints in TRB and TRG genes in pigs and the frequencies of corresponding trans-rearrangements involving TRA/TRD locus in humans. Complex structure of the pig TRA/TRD locus with high number of potential V(D)J rearrangements compared to the human locus may account for the observed differences. Furthermore, we demonstrated that trans-rearrangements involving pig TRA/TRD locus occur at lower frequencies in γδ T cells than in αβ T lymphocytes. The decrease of the frequencies in γδ T cells is probably caused by the absence of TRA recombination during maturation of this T cell lineage. High numbers of innocent trans-rearrangements in pigs may indicate a higher risk of T-cell lymphoma than in humans.

show abstract

Congenital and hereditary tumours in domestic animals. 2. Pigs. A review

Cited by 36 publications

References 39 publications

Neoplasmas em suínos: 37 casos

Neoplasmas em suínos: 37 casos

A large preclinical animal model to assess ex vivo skin gene therapy applications

Illegitimate recombination between T cell receptor genes in humans and pigs (Sus scrofa domestica)

Contact Info

Product

Resources

About