Hereditary gingival fibromatosis: Report on three families and dermatoglyphic analysis

Abstract

Some syndromes that include gingival fibromatosis are associated with abnormalities of the hands and feet. The purpose of this work was to establish whether gingival fibromatosis, as an isolated disease, can be connected with disturbances in the development of the digitopalmar structures. In three families with 40 members, fibromatosis manifested in 16 (7 males and 9 females). The disease was transmitted as an autosomal dominant trait. Dermatoglyphics were analyzed in the proband in each family and in their fathers who had fibromatosis. The analysis showed the presence of patterns in IV interdigital areas in all patients. The fathers of 2 probands had double loops in the IV interdigital area, which is very rare in the general population (frequency, 0.6%). The position of the axial triradius was moderately distal (t') in 1, and markedly distal (t") in another, and in 4 it was borderline (tb). Total finger ridge count was increased, which indicated the increased size of the volar embryonal pads. Distorted dermatoglyphic findings may be considered microform abnormalities of the fingers and hands. Since dermatoglyphics are highly genetically controlled and reflect the status of the embryonal pads, the results suggest disharmony in the development of the mesodermal structures of the hands.

Role of dermatoglyphics as an indicator of precancerous and cancerous lesions of the oral cavity

“…[234567891011121314151617] In dentistry, dermatoglyphics have been studied to help predict disorders like cleft lip and cleft palate, dental caries, malocclusion, congenital anomalies like ectodermal dysplasia, gingival fibromatosis, periodontitis, bruxisium etc. [1819202122232425262728]…”

Hereditary Gingival Fibromatosis: Report of a Five‐Generation Family Using Cellular Proliferation Analysis

“…As such, HGF has been recorded in association with hypertrichosis, 3 mental retardation, 4 epilepsy, 5 progressive sensorineural hearing loss, 6 and abnormalities of the extremities, particularly of fingers and toes. 7 Of these ancillary features, hypertrichosis is the most commonly associated feature. 3,8 HGF has an autosomal dominant mode of inheritance; however, an autosomal recessive mode of inheritance has also occasionally been reported.…”

Histomorphometric characteristics and expression of epidermal growth factor and its receptor by epithelial cells of normal gingiva and hereditary gingival fibromatosis

“…HGF may manifest as an isolated finding or in association with other features, as part of a syndrome. As such, HGF has been recorded in association with hypertrichosis, mental retardation, epilepsy, progressive hearing loss and abnormalities of the extremities, particularly fingers and toes (2–7). In most of the cases, an autosomal dominant mode of inheritance with variable penetrance and expressivity is involved; however, the disease may be found as an autosomal recessive disorder (8, 9).…”