Hereditary gingival fibromatosis

Laband, Peter F.; Humphreys, Georgina S

doi:10.1016/0030-4220(64)90506-7

Cited by 82 publications

(14 citation statements)

References 4 publications

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“…Although sharing some similar syndromes, TBS and ZLS patients show distinct features: the former is characterized by intellectual disability, epilepsy, and hypoplasia or aplasia of the nails of the thumb and great toes [101, 102], and the latter is characterized by gingival enlargement, intellectual disability, hypoplasia or absence of all nails and terminal phalanges, and hypertrichosis and associated with or without epilepsy [103–105], respectively. Using whole-exome sequencing (WES) technique, Simons et al [23] and Kortüm et al [21] almost simultaneously connected the genetic causes of ZLS and TBS to EAG1 channel gain-of-mutations.…”

Section: Eag1 Channel Dysfunction In Genetic Neurological Diseasementioning

confidence: 99%

Eag1 K⁺ Channel: Endogenous Regulation and Functions in Nervous System

Han

Tokay

Zhang

et al. 2017

Oxidative Medicine and Cellular Longevity

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Ether-à-go-go1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.

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Section: Eag1 Channel Dysfunction In Genetic Neurological Diseasementioning

confidence: 99%

Eag1 K⁺ Channel: Endogenous Regulation and Functions in Nervous System

Han

Tokay

Zhang

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Authors have agreed that there is more sub-epithelial fibroblast proliferation and greater collagen and fibronectin synthesis and, at the same time, a reduction in the matrix metalloproteinases (MMPs) entrusted with collagen degradation (4,8-12). …”

Section: Introductionmentioning

confidence: 99%

“…The rise in TGFß1 leads to increased proliferation of fibroblasts, which remain phenotypically activated synthesizing collagen and fibronectin. This would cause an imbalance between the synthesis and degradation of extracellular matrix molecules (3,5,8-12). …”

Section: Introductionmentioning

confidence: 99%

“…It covers the teeth partially or totally and can be localized or generalized, with a variable degree of severity, but does not affect the bone (2,4,5,8,11). It usually interferes with speech, lip closure and chewing but above all, at the ages at which it appears, it can become a psychological burden and affect the patient’s self-esteem (2,5).…”

Section: Introductionmentioning

confidence: 99%

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Hereditary gingival fibromatosis: Characteristics and treatment approach

et al. 2017

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Hereditary gingival fibromatosis (HGF) is a rare disorder characterized by a benign, non-hemorrhagic, fibrous gingival overgrowth that can appear in isolation or as part of a syndrome. Clinically, a pink gingiva with marked stippling can be seen to cover almost all the tooth, in many cases preventing eruption. HGF usually begins during the transition from primary to permanent teeth, giving rise to a condition that can have negative psychological effects at that age. As it does not resolve spontaneously, the treatment of choice is gingivectomy, which can be performed with an internal or external bevel incision, depending on each case and bearing in mind the changes that will take place at the dentogingival junction (DGJ). This paper describes clinical aspects and treatment in two eight-year-old boys with HGF, considering different facets of the surgical approach with conscious sedation in young children.

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“…[2] The familial variation may occur with a number of other inherited syndromes when it could be associated with some of the following; for e.g., Zimmerman Laband syndrome,[1112] Murray Puretic drescher (juvenile hyaline fibromatosis),[13] Rutherfurd, Cross, Cowden syndrome, multiple hamartomas, tuberous sclerosis. [614]…”

Section: Introductionmentioning

confidence: 99%

Hereditary gingival fibromatosis

Dhadse¹,

Yeltiwar²,

Pandilwar³

et al. 2012

J Indian Soc Periodontol

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Hereditary gingival fibromatosis is a rare benign oral condition characterised by slow and progressive enlargement of both maxillary and mandibular attached gingiva. It may develop as an isolated disorder but can feature along with a syndrome. A case of 12 year old female child who presented with generalised severe gingival overgrowth, involving both the arches and covering almost the entire dentition, and had all the teeth remaining invisible within the confinement of gingival tissues. The excess gingival tissue, in this non-syndromic case was removed by conventional gingivectomy using local as well as general anaesthesia. The post-operative result was uneventful and the patient appearance improved considerably. Good aesthetic result was achieved to allow patient to practice oral hygiene measures. After treatment regular recall visits are necessary in order to evaluate oral hygiene and stability of periodontal treatment.

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Hereditary gingival fibromatosis

Cited by 82 publications

References 4 publications

Eag1 K⁺ Channel: Endogenous Regulation and Functions in Nervous System

Eag1 K⁺ Channel: Endogenous Regulation and Functions in Nervous System

Hereditary gingival fibromatosis: Characteristics and treatment approach

Hereditary gingival fibromatosis

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Hereditary gingival fibromatosis

Cited by 82 publications

References 4 publications

Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System

Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System

Hereditary gingival fibromatosis: Characteristics and treatment approach

Hereditary gingival fibromatosis

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Eag1 K⁺ Channel: Endogenous Regulation and Functions in Nervous System

Eag1 K⁺ Channel: Endogenous Regulation and Functions in Nervous System