Hereditary elliptocytosis with protein band 4.1 deficiency in the dog

Smith, Joseph; Moore, K. E.; Arens, Marlys; Rinderknecht, G.A.; Ledet, A. E.

doi:10.1182/blood.v61.2.373.373

Cited by 25 publications

(3 citation statements)

References 22 publications

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“…Spectrin deficiency was identified using a radioimmune assay (RIA) in a population of Dutch Golden Retrievers with persistent increased OF . In addition, protein band 4.1 deficiency was identified in a dog with compensated hemolysis and persistent reticulocytosis using SDS‐PAGE . In contrast, 2 recent studies in cats described a strong suspicion of an RBC membrane defect but were unable to elucidate the protein responsible, despite 1 study using SDS‐PAGE.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the red blood cell proteome in a dog with unexplained hemolytic anemia

Black

Heesom

Whittington

et al. 2018

Veterinary Clinical Pathol

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A 7-year-old female neutered Jack Russell Terrier was presented to Langford Vets, the University of Bristol, with a history of chronic intermittent lethargy. Investigations and clinical course were compatible with hereditary hemolysis due to a red blood cell membrane defect. Proteomics was used to explore protein alterations in the presence of a hypothesized red blood cell membrane protein deficiency. Proteomic analysis revealed downregulation of the band 3, and alpha- and beta-adducin proteins, and alterations in the red blood cell proteome consistent with previous reports of changes due to the presence of reticulocytosis and ongoing hemolysis. The spectrum of protein alterations identified in the affected dog may be homologous to a band 3 protein deficiency secondary to hereditary spherocytosis, as described in people.

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Section: Discussionmentioning

confidence: 99%

Assessment of the red blood cell proteome in a dog with unexplained hemolytic anemia

Black

Heesom

Whittington

et al. 2018

Veterinary Clinical Pathol

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“…The spleen normally removes them but, in horses and cats having non-sinusoidal spleen, few HJ bodies are normally seen in smear. [14][15][16] Increased numbers of HJ bodies can be seen as part of a regenerative response to anemia, in animals with hypo functioning spleens, or in splenectomized patients. There also are reports of increased numbers of HJ bodies in non-anemic miniature and toy poodles with hereditary macrocytosis.…”

Section: Howell-jolly (Hj) Bodiesmentioning

confidence: 99%

Abnormal Scenes in a Blood Film

Kumar¹

2016

HTIJ

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Examination of peripheral blood smear is a vital step in assessment of overall health status of the individual. Blood smear examination is part of standard hematologic profiles and as a part of the diagnostic evaluation of apparently ill patient. In addition to differential leucocyte count, blood smear examination may reveal a variety of information of diagnostic value, for instance defective RBC morphology suggests chronic blood loss, endogenous or exogenous intoxication, vascular disorders or immune mediated disorders. Pathomorphological changes in WBCs are the first signs of inflammatory conditions and may be diagnostic for certain inherited conditions and leukemias that can be only are detected through microscopic evaluation of peripheral blood smears. In some cases, infectious agents pathognomonic cellular inclusions, and neoplastic cells are observed on blood films, yielding an immediate, definitive diagnosis. Every complete blood count (CBC) should be followed by blood smear evaluation that provides morphologic confirmation of hematologic parameters, assurance of the quality of values obtained from automated analyzers, and additional important information not given by automated methods. It is very easy and inexpensive to prepare a blood smear and one can acquire experience readily in evaluation of blood smear with regular practice supported by adequate background information.

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“…As typical poikilocytes, the morphological parameters of elliptocytes can indicate underlying diseases, such as liver disease [3], myelofibrosis and inherited congenital RBC 1 Author to whom any correspondence should be addressed. abnormalities [4,5]. In traditional methods, the acquisition of RBC morphological parameters depends on the analysis of blood smears.…”

Section: Introductionmentioning

confidence: 99%

Elliptocyte detection technology based on super-resolution algorithms for a lensless imaging system

Dai

et al. 2020

Meas. Sci. Technol.

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As typical poikilocytes, elliptocytes can indicate underlying diseases and are an important additional diagnostic parameter. The current method is to use a microscope for manual analysis of blood smears, which is non-automatic, time-consuming and requires skilled technicians. Lab-on-a-chip technology using a lensless imaging system provides a better solution. However, diffraction effects and low resolution are the two main problems faced by lensless imaging systems. In this paper, Fresnel diffraction at a straight edge is used to analyse the relationship between the red blood cell edge and diffraction rings. First, the diffraction characteristics of red blood cell edges are given. Next, the measurement accuracy is improved. The super-resolution algorithm proposed in this paper can make the measurement accuracy reach at least 1% of the pixel size, which can meet the needs of elliptocyte detection. Then, the complete elliptocyte detection algorithm is given. Finally, by analysing the diffraction characteristics of a typical elliptocyte in detail, a very good match with the elliptocyte images is achieved under the microscope. This proves that the detection technology is effective.

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Hereditary elliptocytosis with protein band 4.1 deficiency in the dog

Cited by 25 publications

References 22 publications

Assessment of the red blood cell proteome in a dog with unexplained hemolytic anemia

Assessment of the red blood cell proteome in a dog with unexplained hemolytic anemia

Abnormal Scenes in a Blood Film

Elliptocyte detection technology based on super-resolution algorithms for a lensless imaging system

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