Herd-Level Monitoring and Prevention of Displaced Abomasum in Dairy Cattle

Caixeta, Luciano; Herman, Julia A.; Johnson, Gearold R.; McArt, J.A.A.

doi:10.1016/j.cvfa.2017.10.002

Cited by 18 publications

(16 citation statements)

References 76 publications

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“…Following parturition, up to 35-50% of high producing dairy cows are affected by metabolic and infectious diseases. Displaced abomasum is a multifactorial disorder usually diagnosed in early lactation dairy cows, and is a common inherited condition in Holstein cows (Zerbin et al 2015;Doll 2015;Caixeta et al 2018). The incidence of DA in the United States dairy herds was determined to be approximately 3.5% (NAHMS-USDA 2017).…”

Section: Introductionmentioning

confidence: 99%

Nuclear magnetic resonance (NMR)-based metabolome profile evaluation in dairy cows with and without displaced abomasum

Basoglu

Başpınar

Tenori

et al. 2020

Veterinary Quarterly

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Erdem Gulersoy (2020) Nuclear magnetic resonance (NMR)-based metabolome profile evaluation in dairy cows with and without displaced abomasum, Veterinary Quarterly, 40:1, 1-15, ABSTRACT Background: Displaced abomasum (DA) is a condition of dairy cows that severely impacts animal welfare and causes huge economic losses. Objective: To assess the metabolic status of the disease using metabolomics in serum, urine and liver samples aimed at both water soluble and lipid soluble fractions. Methods: Fifty Holstein multiparous cows with DA (42 left, 8 right) and 20 clinically healthy Holstein multiparous cows were used. Left DA was associated with concomitant ketosis in 19 animals and right in two. NMR-based metabolomics approach and hematological and biochemical analyses were performed. Statistical analysis was carried out on 1 H-NMR data after they have been normalized using PQN method. Results: Contrary to generated PCA score plots the OPLS-supervised method revealed differences between healthy animals and diseased ones based on serum water-soluble samples. While water and lipid soluble metabolites decreased in serum samples, fatty acid fractions and cholesterol were increased in liver samples in DA affected cows. The metabolomic and chemical profiles clearly revealed that cows with DA (especially with LDA) were at risk of ketosis and fatty liver. Serum hippuric acid concentration was significantly higher in healthy cows in comparison with LDA, whereas serum glycine concentration was reported higher for healthy when compared to RDA affected animals. Conclusion: A biochemical network and pathway mapping revealed 'valine, leucine and isoleucine biosynthesis' and 'phenylalanine, tyrosine and tryptophan biosynthesis' as the most probable altered metabolic pathway in DA condition. Serum was advocated as the optimal biological matrix for the 1 H-NMR analysis. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Nuclear magnetic resonance (NMR)-based metabolome profile evaluation in dairy cows with and without displaced abomasum

Basoglu

Başpınar

Tenori

et al. 2020

Veterinary Quarterly

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“…These metabolic changes, combined with suboptimal dry matter intake (DMI), increase the risk of concomitant health disorders that occur disproportionately during transition [2, 3]. Health disorders with high incidence during this period include milk fever (5 to 7% [4];), subclinical ketosis (22.4 to 55.7% [5];), retained fetal membranes (4%, after a normal calving [6];), metritis (18.5 to 27.6% [7];) and displaced abomasum (3.5% [8];), besides increased severity of mastitis [9]. All of these disorders have adverse effects on animal welfare, milk production, reproduction, and farm profitability [10, 11].…”

Section: Introductionmentioning

confidence: 99%

The effect of an organic rumen-protected fat supplement on performance, metabolic status, and health of dairy cows

et al. 2019

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BackgroundNegative energy balance during the transition period is a concern for both conventional and certified organic dairy systems. During early lactation, supplemental strategies are used to cope with nutrient deficiencies that are associated with impaired health, production, and reproduction. As organic certified dairies in the United States face restricted access to dietary supplements, the evaluation of products especially formulated for organic production is needed. Our objective was to assess the effect of supplementing 0.45 kg/d of an organic rumen-protected fat (RPF) on health, metabolic status, and productive and reproductive performance of organic certified Holstein cows from 1 to 150 days in milk (DIM). Two-hundred and two cows were enrolled in a randomized blocked controlled trial conducted from January to July 2017 in a certified organic dairy located in Northern Colorado (USA). Two groups were randomly assigned to be individually supplemented with organic RPF (ORG; n = 100) or control pellets (CON; n = 102) once per day, in addition to the total mixed ration (TMR). Outcomes of interest included milk yield (kg/d) and milk components, serum concentration of glucose, and non-esterified fatty acids (NEFA), resumption of cyclicity, time-to-first artificial insemination (AI), conception at first AI, and conception within 150 DIM, disease occurrence, culling, mortality.ResultsA significant effect for the inclusion of RPF was found in daily milk yield; RPF supplemented cows had greater milk yield (1.6 kg/d) compared to CON cows up to 150 DIM (P = 0.03). During grazing, multiparous (MP) ORG cows had greater milk yield compared to MP CON cows, whereas no effect was found in primiparous (PP) cows. Health outcomes, serum metabolite concentrations, and reproductive performance were not affected by the inclusion of RPF. Body condition loss was smaller in the ORG group up to 80 DIM; however, there was no effect on body condition during the grazing season and in the overall study period.ConclusionsThese results indicate that supplementation of RPF increased daily milk yield and prevented body condition loss during at 90 DIM. However, RPF supplementation did not affect health, serum metabolite concentration, milk components, and reproductive outcomes.

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“…Displaced abomasum (DA) in dairy cows is the abnormal positioning of the abomasum from its normal position in the abdomen to the right (RDA) or left (LDA) side, with LDA being more frequently diagnosed than RDA. The incidence of DA ranges from 1.7% to 5.8% [111,112]. The ratio of left to right DA in Holstein dairy cows ranges between 3:1 and 7:1 [113][114][115].…”

Section: Displaced Abomasummentioning

confidence: 99%

Bacterial Endotoxins and Their Role in Periparturient Diseases of Dairy Cows: Mucosal Vaccine Perspectives

Eckel

Ametaj

2020

Dairy

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During the periparturient period there is a significant increase in the incidence of multiple metabolic and infectious diseases in dairy cows. Dairy cows are fed high-grain diets immediately after calving to support production of large amounts of milk. Mounting evidence indicates these types of diets are associated with the release of high amounts of endotoxins in the rumen fluid. If infected, the udder and uterus additionally become important sources of endotoxins during the postpartum period. There is increasing evidence that endotoxins translocate from rumen, uterus, or udder into the systemic circulation and trigger chronic low-grade inflammatory conditions associated with multiple diseases including fatty liver, mastitis, retained placenta, metritis, laminitis, displaced abomasum, milk fever, and downer cow syndrome. Interestingly, endotoxin-related diseases are triggered by a bacterial component and not by a specific bacterium. This makes prevention of these type of diseases different from classical infectious diseases. Prevention of translocation of endotoxins into the host systemic circulation needs to take priority and this could be achieved with a new approach: mucosal vaccination. In this review article, we discuss all the aforementioned issues in detail and also report some of our trials with regards to mucosal vaccination of periparturient dairy cows.

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Herd-Level Monitoring and Prevention of Displaced Abomasum in Dairy Cattle

Cited by 18 publications

References 76 publications

Nuclear magnetic resonance (NMR)-based metabolome profile evaluation in dairy cows with and without displaced abomasum

Nuclear magnetic resonance (NMR)-based metabolome profile evaluation in dairy cows with and without displaced abomasum

The effect of an organic rumen-protected fat supplement on performance, metabolic status, and health of dairy cows

Bacterial Endotoxins and Their Role in Periparturient Diseases of Dairy Cows: Mucosal Vaccine Perspectives

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