Herbo-medicinal formulation; Marham-e-raal: A potent ointment for acute and chronic wounds – A review

Ahmad, Waseem; Alam, Shah; Aquil, Zareena

doi:10.4103/tjps.tjps_48_18

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Aqueous extract of these plants has shown high-level anti-staphylococci activities that could be harnessed to develop an antibacterial agent for SSTIs. Formulating these extracts with skin ointment, wound wash, antiseptics, and surgical wound dressing pad would accelerate effective healing process involving coagulation, epithelization, collagenation, wound contraction and reduce septic skin inflammation [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activities of plant leaf extracts against multi-antibiotic resistant Staphylococcus aureus associated with skin and soft tissue infections

Akinduti¹,

Emoh-Robinson²,

Obamoh-Triumphant³

et al. 2022

BMC Complement Med Ther

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Background The antibacterial activities of aqueous leaf extracts of Moringa oleifera, Vernonia amygdalina, Azadirachta indica and Acalypha wilkesiana against multidrug resistance (MDR) Staphylococcus aureus associated with skin and soft tissue infections were investigated. Methods Staphylococcus aureus (n = 183) from the skin and soft tissue infections with evidence of purulent pus, effusions from aspirates, wounds, and otorrhea were biotyped, and evaluated for biofilm production. The phenotypic antibiotic resistance and MDR strains susceptibility to plant leaves extract were determined using disc diffusion and micro-broth dilution assays respectively. The correlation of plant extract bioactive components with inhibitory activities was determined. Results High occurrence rate of S. aureus were recorded among infant and adult age groups and 13.2% mild biofilm producers from the wound (p < 0.05). Of 60.2% MDR strains with overall significant MARI of more than 0.85 (p < 0.05), high resistant rates to linozidine (92.7%; 95% CI:7.27–10.52), ofloxacin (94.2%; 95% CI:6.09–8.15), chloramphenicol (91.2%; 95% CI:6.11–8.32), gentamicin (97.3%; 95% CI:6.20–8.22), ciprofloxacin (92.7%; 95% CI: 5.28–7.99) and vancomycin (86.6%; 95% CI:6.81–9.59) were observed. Vernonia amygdalina and Azadirachta indica showed significant antimicrobial activity at 100 mg/ml and 75 mg/ml, with low susceptibility of less than 10% to 25 mg/ml, 50 mg/ml, and 75 mg/ml Moringa oleifera. Alkaloids, saponin and terpenoids were significant in Moringa oleifera, Acalypha wilkesiana, Azadirachta indica and Vernonia amygdalina leaves extracts (p < 0.05). High inhibitory concentrations at IC50; 3.23, 3.75 and 4.80 mg/ml (p = 0.02, CI: − 0.08 – 11.52) and IC90; 12.9, 7.5, and 9.6 mg/ml (p = 0.028, CI: 2.72–23.38) were shown by Acalypha wilkesiana, Vernonia amygdalina and Moringa oleifera respectively. Comparative outcome of the plant extracts showed Acalypha wilkesiana, Vernonia amygdalina and Moringa oleifera to exhibit significant inhibition activities (p < 0.05) compared to other extracts. Significant median inhibitory concentration (15.3 mg/ml) of Azadirachta indica were observed (p < 0.01) and strong associations of phytochemical compounds of Azadirachta indica (eta = 0.527,p = 0.017), Vernonia amygdalina (eta = 0.123,p = 0.032) and Acalypha wilkesiana (eta = 0.492,p = 0.012) with their respective inhibitory values. Conclusion Observed high occurrence rate of skin and soft tissue infections caused by biofilm-producing MDR S. aureus requires alternative novel herbal formulations with rich bioactive compounds from Moringa oleifera, Acalypha wilkesiana, Azadirachta indica and Vernonia amygdalina as skin therapeutic agents.

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Section: Discussionmentioning

confidence: 99%

Antibacterial activities of plant leaf extracts against multi-antibiotic resistant Staphylococcus aureus associated with skin and soft tissue infections

Akinduti¹,

Emoh-Robinson²,

Obamoh-Triumphant³

et al. 2022

BMC Complement Med Ther

View full text Add to dashboard Cite

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Vateria indica (Linn) resin based ointment for the topical treatment of Radiation-Induced burns in cancer patients

Mirza

Hasan

Ramesh

et al. 2023

Journal of King Saud University - Science

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Clinical Impact of eCASH Combined with Nano-Silver Dressings for the Treatment of II Burn Wounds

Yang

Zhou

Ding

et al. 2021

j biomater tissue eng

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92 cases of second degree burn wounds treated in our hospital from January 2019 to December 2019 were selected as the research objects, and the clinical effect of eCASH concept treatment combined with nano silver dressing on the second degree burn wounds was studied. The patients were randomly divided into control group (n = 46) and observation group (n = 46). The control group was treated with conventional treatment combined with eCASH concept nursing, and the observation group was treated with eCASH concept combined with nano silver dressing. We found that the effective rate of the observation group was 95.65% higher than that of the control group (76.09%); the wound healing time of the observation group was significantly lower than that of the control group; the average VAS pain score of the observation group during wound treatment was significantly lower than that of the control group The total positive rate of bacterial detection in the observation group was 8.70%, which was lower than 28.26% in the control group; the incidence of complications in the observation group was 2.17% lower than that in the control group (17.39%); the differences were statistically significant (all P < 0.05). These results indicate that eCASH concept combined with nano silver dressing in the treatment of second degree burn wounds has a significant effect, which can accelerate the recovery, reduce the pain, and effectively reduce the total positive rate of bacterial detection and the incidence of complications.

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Herbo-medicinal formulation; Marham-e-raal: A potent ointment for acute and chronic wounds – A review

Cited by 3 publications

References 3 publications

Antibacterial activities of plant leaf extracts against multi-antibiotic resistant Staphylococcus aureus associated with skin and soft tissue infections

Antibacterial activities of plant leaf extracts against multi-antibiotic resistant Staphylococcus aureus associated with skin and soft tissue infections

Vateria indica (Linn) resin based ointment for the topical treatment of Radiation-Induced burns in cancer patients

Clinical Impact of eCASH Combined with Nano-Silver Dressings for the Treatment of II Burn Wounds

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