Herbal transdermal patches made from optimized polyvinyl alcohol blended film: Herbal extraction process, film properties, and in vitro study

Monton, Chaowalit; Sampaopan, Yupaporn; Pichayakorn, Wiwat; Panrat, Kamon; Suksaeree, Jirapornchai

doi:10.1016/j.jddst.2022.103170

Cited by 17 publications

(16 citation statements)

References 38 publications

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“…When the amount of G. applanatum extracts was increased, folding endurance that was decreased. This was because the herbal extracts might make the film less flexible which was related to the earlier publication of the herbal film [19,22]. When the amount of EC and TEC increased, folding endurance that was positively correlated increased.…”

Section: Resultsmentioning

confidence: 99%

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Modelling Mechanical Properties of Topical Films Containing Ganoderma applanatum using the Design of Experiments

Monton

Suksaeree

2023

Trends Sci

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With the guidance of Design-Expert® software version 11, the mechanical properties of topical films containing Ganoderma applanatum (G. applanatum) extracts were investigated. While ethyl cellulose (EC), G. applanatum extracts, and triethyl citrate (TEC) were independent factors, ultimate tensile strength (UTS), elongation at break, and folding endurance were dependent variables. The best relationships between UTS, elongation at break, and folding endurance could be predicted more accurately using quadratic, 2FI, and linear models, respectively. The ratio of EC, G. applanatum extracts, and TEC was predicted by the Design of Experiments (DoE) to be 2.6: 2.8: 2.8. The model’s suitability for predicting outcomes inside the design space without necessitating extra trials was established by proving that the ratio’s value of prediction was more than 4. The experimental values of UTS, elongation at break, and folding endurance were 82.15±7.42 MPa, 87.40±15.56 %, and 79±6 folds, respectively. The percent errors of prediction were 12.27, 15.49, and 11.82 %, respectively. The Design-Expert® software’s DoE effectively demonstrated a low percent error of the prediction of less than 20 %. This was suitable and acceptable for developing film formulation in drug delivery systems. HIGHLIGHTS The formulations of topical films containing applanatum extract were optimized, and they were improved EC and TEC were used as polymer matrix and plasticizer, respectively The best relationships between UTS, elongation at break, and folding endurance could be predicted more accurately using quadratic, 2FI, and linear models, respectively UTS, elongation at break, and folding endurance experimental values were 82.15±7.42 MPa, 87.40±15.56 %, and 79±6 folds Less than 20 % was effectively proven which was enough and acceptable GRAPHICAL ABSTRACT

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Section: Resultsmentioning

confidence: 99%

“…A film sample's ability to maintain a certain number of folds before breaking was investigated. The number of folds a film sample could withstand before cracking was used to calculate its folding endurance [19,20].…”

Section: Folding Endurancementioning

confidence: 99%

Modelling Mechanical Properties of Topical Films Containing Ganoderma applanatum using the Design of Experiments

Monton

Suksaeree

2023

Trends Sci

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“…A DPPH solution (200 μL) was used as a control. After incubation for 30 min at room temperature, the absorbance values were taken at 517 nm using a UV–visible spectrophotometer (Shimadzu UV-2600, Infinite 200 PRO microplate plate reader). , Inhibition of free radical scavenging activity was then calculated by using eq . % .25em a n t i o x i d a n t .25em p o t e n t i a l = A 0 − A 1 / A 0 × 100 A 0 represents the optical density (absorbance) of the DPPH free radical with methanol, and A 1 represents the optical density of the DPPH radical with samples.…”

Section: Materials and Methodsmentioning

confidence: 99%

Niacin-Loaded Liquid Crystal Nanoparticles Ameliorate Prostaglandin D2-Mediated Niacin-Induced Flushing and Hepatotoxicity

Javaid,

K A,

Sharma

et al. 2024

ACS Appl. Nano Mater.

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Niacin plays a significant role in the therapy and management of mixed dyslipidemia. Nevertheless, its administration in raw form is contraindicated due to potential adverse effects including hepatotoxicity and cutaneous flushing. Prostaglandin D2 (PGD2) plays a crucial role in the signaling cascade of niacin-induced flushing. To address the potential adverse reactions linked to niacin therapy, we developed a niacin-loaded lyotropic liquid crystal nanoparticle (NLCS) crafted explicitly for the oral administration of niacin. NLCSs were produced by disrupting the cubic gel of glyceryl monostearate (GMS). The nanoparticles demonstrated notable drug-loading capabilities with a size of approximately 255 ± 31.6 nm. Furthermore, NLCS displayed sustained release behavior, indicating their potential for controlled and prolonged drug delivery. Efficient encapsulation and minimal interaction between niacin and other excipients were evidenced through Fourier transform infrared and X-ray diffraction studies, establishing their high stability. In vitro studies suggested that the nanoparticles had good antioxidant activity, swelling behavior, and biocompatibility. Additionally, compared to raw niacin, NLCS showed a higher in vivo therapeutic efficacy, less hepatotoxicity, a more refined lipid profile, and an improved complete blood count (CBC) profile. In addition, it was shown that animals treated with NLCS had lower PGD2 levels than those treated with raw niacin. In conclusion, our study highlights the potential of NLCS as a promising strategy to alleviate the side effects linked to the direct ingestion of pure niacin. These nanoparticles offer a solution to flushing-like symptoms and hepatotoxicity, positioning them as a viable therapeutic option for managing dyslipidemia.

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“…Kinetic models were used to analyze the drug-release mechanism from DOX-loaded polysaccharide films. − Zero-order (eq ), first-order (eq ), and Higuchi (eq ) and Korsmeyer–Peppas models in eq have been used. , In eqs –, M t denotes the quantity of drug released at distinct time points t, M 0 corresponds to the initial amount of drug present within the release medium (in this case, M 0 = 0), R 0 signifies the initial ratio of drug in the release medium (in this case, R 0 = 0), K 0 and K 1 are the zero- and first-order release constants, respectively, K H is the Higuchi dissolution constant, K KP stands for the Korsmeyer–Peppas rate constant, M t / M ∞ signifies the percentage of drug released at specific time points t, and n is the diffusion exponent. The values of n serve to characterize the drug-release mechanism. M t = M 0 + K 0 t log ( 100 − M t M ∞ × 100 ) = log ( 100 − M 0 M ∞ × 100 ) − K 1 t M = K H t 0.5 M normalt M ∞ = K normalK normalP t n Values of “ n ″ falling within the range of 0.5–1.0 signify non-Fickian diffusion, implying anomalous transport kinetics.…”

Section: Materials and Methodsmentioning

confidence: 99%

“…Kinetic models were used to analyze the drug-release mechanism from DOX-loaded polysaccharide films. − Zero-order (eq ), first-order (eq ), and Higuchi (eq ) and Korsmeyer–Peppas models in eq have been used. , In eqs –, M t denotes the quantity of drug released at distinct time points t, M 0 corresponds to the initial amount of drug present within the release medium (in this case, M 0 = 0), R 0 signifies the initial ratio of drug in the release medium (in this case, R 0 = 0), K 0 and K 1 are the zero- and first-order release constants, respectively, K H is the Higuchi dissolution constant, K KP stands for the Korsmeyer–Peppas rate constant, M t / M ∞ signifies the percentage of drug released at specific time points t, and n is the diffusion exponent. The values of n serve to characterize the drug-release mechanism. Values of “ n ″ falling within the range of 0.5–1.0 signify non-Fickian diffusion, implying anomalous transport kinetics.…”

Section: Materials and Methodsmentioning

confidence: 99%

Controllable Drug-Release Ratio and Rate of Doxorubicin-Loaded Natural Composite Films Based on Polysaccharides: Evaluation of Transdermal Permeability Potential

Lee,

Tsubota,

Tachibana

2023

ACS Omega

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In drug delivery systems, it is crucial to develop a drug carrier capable of regulating both the drug-release rate and the drug-release ratio. This study proposes a method for controlling the drug-release ratio/rate using doxorubicin-loaded natural composite films composed of polysaccharides (cellulose, chitin, chitosan, or cellulose nanocrystal) and mineral substances (MMT: montmorillonite). We succeeded in controlling the doxorubicin release ratio from 25 to 88% depending on the natural polysaccharide. Likewise, the reduction rate differed depending on the type of natural polysaccharide, whereas the reduction in release was achieved by mixing MMT. Cellulose had the largest reduction in the drug release ratio, approximately 30%, and cellulose nanocrystals showed little change. Furthermore, we conducted a skin permeation test on the natural polysaccharide film with the highest release rate to confirm its transdermal permeability potential. The polysaccharide doxorubicin-loaded film sustainably released doxorubicin for 2 days, which indicated the potential of a carrier for DDS applications.

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Herbal transdermal patches made from optimized polyvinyl alcohol blended film: Herbal extraction process, film properties, and in vitro study

Cited by 17 publications

References 38 publications

Modelling Mechanical Properties of Topical Films Containing Ganoderma applanatum using the Design of Experiments

Modelling Mechanical Properties of Topical Films Containing Ganoderma applanatum using the Design of Experiments

Niacin-Loaded Liquid Crystal Nanoparticles Ameliorate Prostaglandin D2-Mediated Niacin-Induced Flushing and Hepatotoxicity

Controllable Drug-Release Ratio and Rate of Doxorubicin-Loaded Natural Composite Films Based on Polysaccharides: Evaluation of Transdermal Permeability Potential

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