Herbal medicines for treating acute otitis media: A systematic review of randomised controlled trials

Son, Mi Ju; Kim, Young Eun; Song, Young-Yeal; Kim, Yun Hee

doi:10.1016/j.ctim.2017.11.001

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…Various herbal medicines have been known to exhibit hepatoprotective properties by increasing cellular antioxidant capacity [ 9 , 37 ]. In this study, we examined the antioxidant capacity in the liver of dill treated animals, and showed potential rise in total antioxidant levels and reduction of malondialdehyde (MDA), compared with those of untreated HC-HF fed rats.…”

Section: Discussionmentioning

confidence: 99%

“…Previous evidence showed that antioxidant supplements have significant role in the prevention and treatment of NAFLD [ 5 ] and Epidemiological studies have reported that fruits, herbs, and spices are associated with lower risks of this disease [ 8 ]. The use of herbal medicine as substitute or complementary treatment for health problems have recently been increased worldwide [ 9 ]. Anethum graveolens (dill) is one of the traditional herbal plant with many useful effects [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Favorable effects of Anethum graveolens on liver oxidative stress and cholesterol 7 alpha-hydroxylase levels in non-alcoholic fatty liver disease (NAFLD) rat models

Abbasi¹,

Goodarzi²,

Tayebinia³

et al. 2021

Metabolism Open

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Background High-fat high-cholesterol diet induces a phenotype similar to non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in humans. In NAFLD and NASH, cholesterol and bile acid metabolisms are impaired to accumulate lipids and toxic bile acids along with cholestatic hepatic damage. Recently, the use of herbal-derived cholesterol lowering products has attracted much attention as possible therapeutic strategies for NAFLD. Hence, the aim of this study was to determine the effects of an Anethum graveolens (dill) on liver cholesterol 7 alpha-hydroxylase and liver fat accumulation in rats. Method Thirty-six rats were randomly divided into 6 groups (n = 6) and received normal diet (ND) or a mixture of chow diet+2% cholesterol+0.5% cholic acid + 20% corn oil as high cholesterol/fat (HC–HF) diet (NAFLD model). Animals were also treated daily with dill tablet or dill extract (300 mg/kg). At the end of the 30 days experiments, serum and liver lipid profile and liver total antioxidant capacity were determined. Cholesterol 7 alpha-hydroxylase mRNA and protein expression levels were determined in the liver and histopathological changes in liver tissues were analyzed by microscope. Results Lipid profiles significantly decreased in dill treated groups (p < 0.05). Liver total antioxidant capacity significantly (p < 0.05) increased and MDA levels markedly (p < 0.05) reduced both in dill tablet and dill extract treated groups (p < 0.05). Both types of treatments caused significant increases in liver cholesterol 7 alpha-hydroxylase gene expression (p < 0.05). Histopathological examinations showed that treatment with dill normalized the hypercholesterolemia-induced changes in liver histology. Conclusion Administration of dill significantly reduced liver fat, oxidative stress and increased cholesterol 7 alpha-hydroxylase enzyme at the both mRNA and protein levels. Dill extract was found more effective than its commercially available tablet.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Favorable effects of Anethum graveolens on liver oxidative stress and cholesterol 7 alpha-hydroxylase levels in non-alcoholic fatty liver disease (NAFLD) rat models

Abbasi¹,

Goodarzi²,

Tayebinia³

et al. 2021

Metabolism Open

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“…Obviously, the choice of halving the full dosage is much dominant in our hospital probably due to its convenience and the conventional thinking of half dose reduction in children. Nevertheless, such xation in Sinupret drops dosage may not be appropriate for younger pediatric patients, and further dosage adjustment based on the age (especially at age 3 and below) should be performed for exibility [9].…”

Section: Dosage Analysis Of Sinupret Drops In Pediatric Patientsmentioning

confidence: 99%

A Study of Current Medication of Sinupret Drops in Chinese Pediatric Patients

Shen

Yan

2020

Preprint

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Background Sinupret drops is commonly used as agent dissolving nasal secretions. However, there is no specific regime of Sinupret drops for pediatric patients in China. Therefore, we investigate its current medication in Chinese pediatric patients to provide a recommendation of safe drug use.Methods We collect 6,893 outpatient and emergency pediatric prescriptions of Sinupret drops (age ≤ 15) and focused on the analysis of practical drug dosage and potential risks.Results One-half of the adult dosage was mainly chosen for out-patient children, while the full adult dosage was much more used for pediatric patients in emergency. Its usage in low-age pediatric patients requires further evaluation and surveillance. The pharmaceutical reaction of ethanol in Sinupret drops with some cephalosporins during drug taking will lead to unexpected drug reactions.Conclusion To prevent potential side effects, treatment with Sinupret drops as an adjunct for pediatric patients should draw more attention from their doctors and pharmacists. The age and weight of pediatric patients need to be considered as important parameters for drug administration of Sinupret drops. It is important to strengthen the education of medication, and much attention should be paid to the interval of drug administration.

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“…In China, it is principally used to alleviate clinical symptoms such as splenic and gastric inadequacy, anorexia, loose motions, shortness of breath, cough, and limb fatigue. To date, several pharmacological studies have been published relating to SLBZP, as shown in Table 1, suggesting that it can exert therapeutic effects on several gastrointestinal diseases via a spectrum of pharmacological approaches [5][6][7][8][9][10][11][12][13]. A systematic review of studies evaluating the treatment of IBS with SLBZP indicated that the mixture was safe and effective in enhancing the cure rate of IBS and diminishing the severity of diarrhea, abdominal pain, and distension [14].…”

Section: Introductionmentioning

confidence: 99%

A Network Pharmacology-Based Study on Irritable Bowel Syndrome Prevention and Treatment Utilizing Shenling Baizhu Powder

Meng

Bai

Wan

et al. 2021

BioMed Research International

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Background and Objective. Irritable bowel syndrome (IBS) is a prevalent disorder of the gastrointestinal system with complex pathogenesis. Shenling Baizhu powder (SLBZP) is a Chinese herbal compound with multicomponent and multitarget characteristics. Increasing volumes of evidence demonstrate that it has a notable therapeutic impact on IBS. This study therefore is aimed at exploring the potential effective components of SLBZP and their mechanisms in IBS treatment utilizing network pharmacology. Methods. Metabolomics was used to detect the secondary metabolites in SLBZP; the target protein was acquired by target fishing according to the compound’s structure. The SymMap database was used to search herbal medicines for the target protein. The target gene of IBS gave rise to the common gene protein which is the potential target of SLBZP in IBS therapy. The interactions between target proteins were analyzed in a STRING database, the protein relationship network was analyzed using Cytoscape software, and the Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the core target gene group was carried out in a DAVID database in order to construct the “compound-traditional Chinese medicine/molecule-target-pathway” network. Molecular docking was used to verify the core protein and its related small molecular compounds. Result. There were 129 types of secondary metabolites in SLBZP. 80 target proteins of these metabolites were potential core targets for IBS treatment including acetylcholinesterase (AChE), arachidonate-5-lipoxygenase (ALOX5), B-cell lymphoma-2 (BCL2), recombinant cyclin D1 (CCND1), and catenin-β1 (CTNNB1), among others. Results from these targets indicated that the most enriched pathway was the tumor necrosis factor (TNF) signaling pathway ( p < 0.001 ) and that the most abundant pathway was signal transduction. In the network nodes of the TNF signaling pathway, the Chinese medicines with the highest aggregation were Lablab semen album and Glycyrrhizae radix et rhizoma ( degree = 11 ). The small molecules with the highest aggregation were oxypeucedanin and 3,5,6,7,8,3 ′ ,4 ′ -heptamethoxyflavone ( degree = 4 ). Molecular docking results confirmed that daidzein 7-O-glucoside (daidzin) had the highest degree of binding to TNF proteins in the TNF signaling pathway. Conclusion. This study shows that SLBZP can treat IBS by influencing multiple targets and pathways, of which the TNF signaling pathway may be the most significant. This typifies the pharmacological characteristics of traditional Chinese medicine, i.e., multiple targets, numerous pathways, and specific therapeutic effects on diseases. SLBZP can therefore be used as a candidate drug for clinical IBS by intervening in human signal transduction.

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Herbal medicines for treating acute otitis media: A systematic review of randomised controlled trials

Cited by 9 publications

References 26 publications

Favorable effects of Anethum graveolens on liver oxidative stress and cholesterol 7 alpha-hydroxylase levels in non-alcoholic fatty liver disease (NAFLD) rat models

Favorable effects of Anethum graveolens on liver oxidative stress and cholesterol 7 alpha-hydroxylase levels in non-alcoholic fatty liver disease (NAFLD) rat models

A Study of Current Medication of Sinupret Drops in Chinese Pediatric Patients

A Network Pharmacology-Based Study on Irritable Bowel Syndrome Prevention and Treatment Utilizing Shenling Baizhu Powder

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