Herbal medicine Davaie Loban in mild to moderate Alzheimer’s disease: A 12-week randomized double-blind placebo-controlled clinical trial

Tajadini, Haleh; Saifadini, Rostam; Choopani, Rasool; Mehrabani, Mitra; Kamalinejad, Mohammad; Haghdoost, Ali Akbar

doi:10.1016/j.ctim.2015.06.009

Cited by 20 publications

(10 citation statements)

References 31 publications

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“…The strongest-docking triterpenoid ligands to TcAChE were 4,23-dihydroburic acid ( E dock = −135.8 kJ/mol) and 3-acetoxy-5,12-ursadien-24-oic acid ( E dock = −131.7 kJ/mol); olibanumol N docked strongly with MmAChE ( E dock = −133.0 kJ/mol). The excellent docking properties of Boswellia triterpenoid ligands to acetylcholinesterase supports the clinical use of frankincense to treat Alzeimer’s disease [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

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Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia Oleo-Gum Resins

Byler

Setzer

2018

Medicines

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Background: Frankincense, the oleo-gum resin of Boswellia trees, has been used in traditional medicine since ancient times. Frankincense has been used to treat wounds and skin infections, inflammatory diseases, dementia, and various other conditions. However, in many cases, the biomolecular targets for frankincense components are not well established. Methods: In this work, we have carried out a reverse docking study of Boswellia diterpenoids and triterpenoids with a library of 16034 potential druggable target proteins. Results: Boswellia diterpenoids showed selective docking to acetylcholinesterase, several bacterial target proteins, and HIV-1 reverse transcriptase. Boswellia triterpenoids targeted the cancer-relevant proteins (poly(ADP-ribose) polymerase-1, tankyrase, and folate receptor β), inflammation-relevant proteins (phospholipase A2, epoxide hydrolase, and fibroblast collagenase), and the diabetes target 11β-hydroxysteroid dehydrogenase. Conclusions: The preferential docking of Boswellia terpenoids is consistent with the traditional uses and the established biological activities of frankincense.

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Section: Resultsmentioning

confidence: 99%

“…resins have been used in Persian traditional medicine as an anti-Alzheimer’s agent [ 36 , 37 ]. Animal models (rat) of Alzheimer’s disease [ 38 , 39 , 40 ] and human clinical trials [ 41 , 42 ] showed beneficial effects on memory with frankincense.…”

Section: Resultsmentioning

confidence: 99%

Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia Oleo-Gum Resins

Byler

Setzer

2018

Medicines

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“…Through in vivo and in vitro studies, various components of herbal medicine have been found to possess the ability to intervene in aging-related diseases by activating telomerase, increasing antioxidant capacity, reducing apoptosis and anti-inflammatory activities, and regulating aging-related pathways and exosomes. We also summarized the clinical randomized controlled trials (RCTs) of herbal medicine in the treatment of aging-related diseases ( Table 3) [240][241][242][243][244][245][246][247][248][249][250]. These trials found that herbal medicine displays certain clinical efficacy in the treatment of agerelated diseases such as type 2 diabetes, vascular dementia, AD, and atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

Liu

Wei-liang

Gao

et al. 2019

Oxidative Medicine and Cellular Longevity

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Aging is a progressive disease affecting around 900 million people worldwide, and in recent years, the mechanism of aging and aging-related diseases has been well studied. Treatments for aging-related diseases have also made progress. For the long-term treatment of aging-related diseases, herbal medicine is particularly suitable for drug discovery. In this review, we discuss cellular and molecular mechanisms of aging and aging-related diseases, including oxidative stress, inflammatory response, autophagy and exosome interactions, mitochondrial injury, and telomerase damage, and summarize commonly used herbals and compounds concerned with the development of aging-related diseases, including Ginkgo biloba, ginseng, Panax notoginseng, Radix astragali, Lycium barbarum, Rhodiola rosea, Angelica sinensis, Ligusticum chuanxiong, resveratrol, curcumin, and flavonoids. We also summarize key randomized controlled trials of herbal medicine for aging-related diseases during the past ten years. Adverse reactions of herbs were also described. It is expected to provide new insights for slowing aging and treating aging-related diseases with herbal medicine.

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“…calamus has also been clinically investigated as a monotherapy as well as in combination with other medicinal herbs in healthy subjects and sufferers of various metabolic and neurological ailments. Most clinical research has looked at the A. calamus effect on obesity, depression, neuroprotection, and cardiovascular disease [178][179][180][181][182][183][184][185][186][187][188][189][190][191]. The data obtained so far can be found in Table 5.…”

Section: Clinical Reportsmentioning

confidence: 99%

Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study

Sharma

Gautam

et al. 2020

JCM

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Vacha (Acorus calamus Linn. (Acoraceae)) is a traditional Indian medicinal herb, which is practiced to treat a wide range of health ailments, including neurological, gastrointestinal, respiratory, metabolic, kidney, and liver disorders. The purpose of this paper is to provide a comprehensive up-to-date report on its ethnomedicinal use, phytochemistry, and pharmacotherapeutic potential, while identifying potential areas for further research. To date, 145 constituents have been isolated from this herb and identified, including phenylpropanoids, sesquiterpenoids, and monoterpenes. Compelling evidence is suggestive of the biopotential of its various extracts and active constituents in several metabolic and neurological disorders, such as anticonvulsant, antidepressant, antihypertensive, anti-inflammatory, immunomodulatory, neuroprotective, cardioprotective, and anti-obesity effects. The present extensive literature survey is expected to provide insights into the involvement of several signaling pathways and oxidative mechanisms that can mitigate oxidative stress, and other indirect mechanisms modulated by active biomolecules of A. calamus to improve neurological and metabolic disorders.

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Herbal medicine Davaie Loban in mild to moderate Alzheimer’s disease: A 12-week randomized double-blind placebo-controlled clinical trial

Abstract: Our findings suggest that DL may be effective in improvement of memory in patients with mild-to-moderate Alzheimer's disease.

Cited by 20 publications

References 31 publications

Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia Oleo-Gum Resins

Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia Oleo-Gum Resins

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study

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