Herbal liposome for the topical delivery of ketoconazole for the effective treatment of seborrheic dermatitis

Dave, Vivek; Sharma, Swati; Yadav, Reena; Agarwal, Udita

doi:10.1007/s13204-017-0634-3

Cited by 45 publications

(26 citation statements)

References 19 publications

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“…Triethanolamine (TEA) was added to neutralize the pH with slow stirring until the gel was formed. The pH of the semisolid ethosomal gel formulations was measured by using pH meter [6].…”

Section: Methodsmentioning

confidence: 99%

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Flurbiprofen loaded ethosomes - transdermal delivery of anti-inflammatory effect in rat model

et al. 2019

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Background Ethosomes have been widely used in Transdermal Drug Delivery System (TDDS) as they increase the permeation of drug across the skin. Methods Flurbiprofen loaded vesicular ethosomes were formulated, optimized and characterized for particle size, entrapment efficiency, poly dispersive index (PDI), microscopy using Atomic force microscopy (AFM), Scanning electron microscope (SEM) and Transmission electron microscopy (TEM) and Interaction of drug and excipients were studied using Fourier transform infra-red (FTIR) spectroscopy, Differential scanning colorimetry (DSC), Thermo gravimetric analysis (TGA). Further, ethosomal formulations of flurbiprofen were evaluated for stability study of three months and in vitro drug permeation study was carried out using albino rat skin. In addition, skin irritation test was evaluated by Draize test and in vivo study of prepared formulation was examined through paw edema assay by inducing carrageenan and cold plate method. Results Amongst all formulations, EF5 formulation exhibited ideal surface morphology, with maximum entrapment efficiency (95%) with optimal excipient concentration i.e. 200 mg phospholipid and 35% ethanol. The ideal vesicle size was achieved as 162.2 ± 2 nm, with zeta potential − 48.14 ± 1.4 mV with the PDI of 0.341. In-vitro permeation study shows a release of 82.56 ± 2.11 g/cm 2 in 24 h and transdermal flux was found as 226.1 μg/cm 2 /h. Cold plate test indicates that the formulation EF5 showed a marked analgesic activity and Carrageenan induced paw edema test indicates that the formulation EF5 inhibits the increase in paw edema. Ethosomal suspension at 4 °C showed maximum stability. Conclusions The overall study concluded that this ethosomal approach offers a new delivery system for sustained and targeted delivery for flurbiprofen. Electronic supplementary material The online version of this article (10.1186/s12944-019-1064-x) contains supplementary material, which is available to authorized users.

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“…Triethanolamine (TEA) was added to neutralize the pH with slow stirring until the gel was formed. The pH of the semisolid ethosomal gel formulations was measured by using pH meter [6].…”

Section: Methodsmentioning

confidence: 99%

“…Ethosomal formulations were dispersed in HPLC water and an instrument was set at an angle of 90° with a medium viscosity of 0.8862 and refractive index 1.361. The particle size distribution, poly dispersibility index and zeta potential were determined; all the measurements were made in triplicates [6].…”

Section: Methodsmentioning

confidence: 99%

Flurbiprofen loaded ethosomes - transdermal delivery of anti-inflammatory effect in rat model

et al. 2019

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“…normal conditions (25±2 °C and 75±5% RH) and refrigerated conditions (4±2 °C and 75±5% RH). During the period of the entire 3 mo, the curcumin-loaded LPHNPs were analyzed for changes in their particle size, polydispersity index and drug entrapment efficiency at a definite interval of 0, 30, 45, 60 and 90 d to assess the stability of the formulations [34].…”

Section: In Vitro Drug Release Kineticsmentioning

confidence: 99%

Boosting the Skin Delivery of Curcumin Through Stearic Acid-Ethyl Cellulose Blend Hybrid Nanocarriers-Based Approach for Mitigating Psoriasis

Jaiswal

Das

2021

Int J App Pharm

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Objective: Curcumin presents poor topical bioavailability when administered orally, which poses a major hurdle in its use as an effective therapy for the management of psoriasis. The present study reports the utilization of lipid-polymer hybrid nanoparticles (LPHNPs) for the topical delivery of curcumin which can be a potential approach for mitigating psoriasis. Methods: Curcumin-loaded LPHNPs were prepared by the emulsification solvent evaporation method and characterized. The optimized Curcumin-loaded LPHNPs (DLN-3) were further incorporated into 2% Carbopol 940 gels and evaluated for its therapeutic efficacy in the Imiquimod (IMQ)-induced psoriasis rat model. Results: The average particle size, polydispersity index, zeta potential, drug entrapment and loading efficiency for DLN-3 were found to be 200.9 nm, 0.342,-28.3 mV, 87.40±0.99% and 4.57±0.04%, respectively. FT-IR, DSC and XRD studies confirmed that all the components used for the formulation are compatible with each other, whereas SEM and TEM analysis affirmed the spherical shape of LPHNPs with a smooth surface. The in vitro drug release studies suggest that curcumin was released from the LPHNPs in a sustained manner over a period of 24 h via super case II transport mechanism. Results of in vitro skin permeation study revealed that 38.39±2.67% of curcumin permeated at 12 h across excised pig ear skin with a permeation flux of 18.74±3.59 µg/cm2/h. Further, in vivo evaluation and histopathological studies demonstrated that NLHG-1 hydrogels showed better therapeutic efficacy against the psoriatic skin lesions than the standard marketed gels. Conclusion: These results suggest that the developed LPHNPs have a superior ability to improve the skin penetration or accumulation of DLN-3 within psoriatic skin and offer a potential delivery system for the management of psoriasis.

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“…The developed liposomes would be characterized and optimized based on their zeta potential, entrapment efficiency, polydispesibility index and skin retention studies. The optimized formulation would be incorporated into topical gel using different polymers along with permeation enhancer and will be characterized for various evaluation parameters (Dave et al, 2017).…”

Section: Experimental Proof Of Hypothesismentioning

confidence: 99%

Andrographolide Loaded Topical Nanocarriers for Management of Psoriasis: A Safe and Effective Approach

Sk¹,

Awasthi²,

Singare³

et al. 2021

PLANT ARCHIVES

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Psoriasis is a chronic inflammatory and hyper proliferative dermatological condition. It has affected an estimate of more than 125 million people worldwide. Topical corticosteroids, topical steroids paring agent, phototherapy or biologics are the major treatment approaches for psoriasis. These therapeutics have several limitations to use in the treatment of psoriasis. Traditional system of medicine utilizes crude herbs for the treatment of chronic diseases which is reasonably safer than the synthetic drugs. Andrographolide is the major active constituent of Andrographis paniculata which is used to treat several diseases. However, Andrographolide delivered using conventional formulations limit its clinical outcomes. Oral bioavailability of andrographolide is poor due to its low aqueous solubility, high lipophilicity, rapid transformation and efflux by P-glycoprotein. Poor oral bioavailability of Andrographolide makes it difficult to synthesize as oral preparation. Liposomes are widely used topical drug delivery carriers to treat skin disorders. Design of andrographolide loaded nanocarrier gel for the management of psoriasis and to reduce the side effects associated with conventional therapies. This hypothesis aimed to incorporate Andrographolide isolated from Andrographis paniculata into a lipid based nanocarrier system. Further, the optimized liposomal formulation would be incorporated into topical gel using different polymers and will be characterized for various evaluation parameters. The synthesized formulation is expected to combine the benefit of small size and structural similarity of the lipid nanocarriers and skin to achieve effective targeting of the diseased skin for psoriasis management.

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Herbal liposome for the topical delivery of ketoconazole for the effective treatment of seborrheic dermatitis

Cited by 45 publications

References 19 publications

Flurbiprofen loaded ethosomes - transdermal delivery of anti-inflammatory effect in rat model

Flurbiprofen loaded ethosomes - transdermal delivery of anti-inflammatory effect in rat model

Boosting the Skin Delivery of Curcumin Through Stearic Acid-Ethyl Cellulose Blend Hybrid Nanocarriers-Based Approach for Mitigating Psoriasis

Andrographolide Loaded Topical Nanocarriers for Management of Psoriasis: A Safe and Effective Approach

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