Herbal Ingredients in the Prevention of Breast Cancer: Comprehensive Review of Potential Molecular Targets and Role of Natural Products

Akkol, Esra Küpeli; Bardakci, Hilal; Barak, Timur Hakan; Aschner, Michael; Karatoprak, Gökçe Şeker; Khan, Haroon; Hussain, Yaseen

doi:10.1155/2022/6044640

Cited by 8 publications

(9 citation statements)

References 237 publications

(281 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, the female population under the age of 30 had a mere 5% chance of developing breast cancer, while those aged 60 and above constituted 20% of breast cancer cases. This report underscores that the age group of 40–60 is associated with the highest incidence of breast cancer ( Küpeli Akkol et al, 2022 ; Majid et al, 2017 ).…”

Section: Introductionsupporting

confidence: 55%

In silico design of novel bioactive molecules to treat breast cancer with chlorogenic acid derivatives: a computational and SAR approach

Sehrawat,

Rathee,

Rathee

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Introduction: Cancer is a vast group of diseases comprising abnormal cells that multiply and grow uncontrollably, and it is one of the top causes of death globally. Several types of cancers are diagnosed, but the incidence of breast cancer, especially in postmenopausal women, is increasing daily. Chemotherapeutic agents used to treat cancer are generally associated with severe side effects on host cells, which has led to a search for safe and potential alternatives. Therefore, the present research has been conducted to find novel bioactive molecules to treat breast cancer with chlorogenic acid and its derivatives. Chlorogenic acid was selected because of its known activity in the field.Methods: Several chlorogenic acid derivatives were subjected to computational studies such as molecular docking, determination of absorption, distribution, metabolism, and excretion (ADME), druglikeness, toxicity, and prediction of activity spectra for substances (PASS) to develop a potential inhibitor of breast cancer. The Protein Data Bank (PDB) IDs used for docking purposes were 7KCD, 3ERT, 6CHZ, 3HB5, and 1U72.Result: Exhaustive analysis of results has been conducted by considering various parameters, like docking score, binding energy, types of interaction with important amino acid residues in the binding pocket, ADME, and toxicity data of compounds. Among all the selected derivatives, CgE18, CgE11, CgAm13, CgE16, and CgE9 have astonishing interactions, excellent binding energy, and better stability in the active site of targeted proteins. The docking scores of compound CgE18 were −11.63 kcal/mol, −14.15 kcal/mol, and −12.90 kcal/mol against breast cancer PDB IDs 7KCD, 3HB5, and 1U72, respectively. The docking scores of compound CgE11 were −10.77 kcal/mol and −9.11 kcal/mol against breast cancer PDB IDs 3ERT and 6CHZ, respectively, whereas the docking scores of epirubicin hydrochloride were −3.85 kcal/mol, −6.4 kcal/mol, −8.76 kcal/mol, and −10.5 kcal/mol against PDB IDs 7KCD, 3ERT, 6CHZ, and 3HB5. The docking scores of 5-fluorouracil were found to be −5.25 kcal/mol, −3.43 kcal/mol, −3.73 kcal/mol, and −5.29 kcal/mol against PDB IDs 7KCD, 3ERT, 6CHZ, and 3HB5, which indicates the designed compounds have a better docking score than some standard drugs.Conclusion: Taking into account the results of molecular docking, drug likeness analysis, absorption, distribution, metabolism, excretion, and toxicity (ADMET) evaluation, and PASS, it can be concluded that chlorogenic acid derivatives hold promise as potent inhibitors for the treatment of breast cancer.

show abstract

Section: Introductionsupporting

confidence: 55%

In silico design of novel bioactive molecules to treat breast cancer with chlorogenic acid derivatives: a computational and SAR approach

Sehrawat,

Rathee,

Rathee

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Reduced Jagged-2 activity resulted in increased caspase activity in the breast tumor cell lines MCF-7 and T47D, suggesting that Notch signaling might prevent apoptosis in these cells. In tumors induced by the mouse mammary tumor virus, Notch-4 was recognized as a potent oncogene, capable of driving the breast epithelium towards a carcinogenic phenotype 149 . These clinical findings underscore the significance of Notch signaling in breast tumor pathogenesis and provide valuable insights into the potential roles of specific Notch receptors and ligands in different stages of mammary tumorigenesis.…”

Section: Clinical Investigation Into Notch Signalling Expressionmentioning

confidence: 99%

Navigating breast cancer complexity: Deciphering the cross talk of Wnt/β catenin and Notch pathways in development and diseases

Rasool,

Bhat,

Khurshid

et al. 2024

Preprint

View full text Add to dashboard Cite

This study investigates miRNA impact on lung, colorectal, and epithelial cancers, emphasizing Wnt3’s role in breast tumor growth through WNT signaling and its influence on mammary stem cells. WNT pathway inactivation induces drug-insensitive, quiescent states in breast cancer stem cells, resulting in resistance to multiple drugs. Tamoxifen-resistant breast carcinoma cells activate both canonical and noncanonical WNT signaling, with Wnt3a enhancing tamoxifen resistance in ER+ carcinoma cells. The study also explores breast cancer immunotherapy, highlighting immune checkpoint blockade targeting PD-1/PD-L1 and CTLA-4 as promising avenues. Additionally, the study explores the NOTCH signaling pathways impact on cancer proliferation, apoptosis, invasion and metastasis. Elevated NOTCH receptor and ligand expression particularly in aggressive triple negative breast cancer correlate with poorer treatment outcome, serving as a predictor for adverse results in breast tumors. The review discusses the relevance of Notch signaling in therapy resistance and breast cancer recurrence. The article encapsulates therapeutic advancements targeting the Notch signaling pathway, weighing merits and demerits in the context of breast cancer treatment. Our study provides a comprehensive understanding of the complex interactions within the WNT and Notch signaling pathways in breast cancer, shedding light on potential therapeutic targets and strategies for personalized treatment. This research significantly contributes to the current body of knowledge, offering promise for improved outcomes in breast cancer patients. The findings underscore the importance of WNT and Notch signaling modulation in developing effective therapeutic interventions for breast cancer.

show abstract

“…Лікопін також пригнічує інсуліноподібний фактор росту-1 [41], пов'язаний з втручанням у сигналізацію рецептора IGF-1 (англ. : insulin like growth factor) та прогресуванням клітинного циклу [42].…”

Section: л е к ц і ї т а о г л я д иunclassified

“…Крім того, було виявлено зниження експресії генів, залучених до епітеліального мезенхімального переходу, таких, як ZEB-1 (англ. : zinc finger E-box binding homeobox-1), фібронектин і клаудин-1 [42].…”

Section: л е к ц і ї т а о г л я д иunclassified

Fibrocystic changes of the mammary glands: interpretation of the diagnosis, issues of diagnosis and treatment (Literature review)

Zavizion

2024

RHW

View full text Add to dashboard Cite

In the Ukrainian-language medical literature there is very little correct information about benign changes in the mammary glands, publications mostly date from the eighties of the last century – the beginning of the current one. This article is a review of modern scientific domestic and foreign sources, which are devoted to the problem of benign changes of the mammary glands and recommendations for their treatment, which are based on the evidence base. The article analyzes 40 publications, mostly by foreign scientists.The prevalence of non-neoplastic changes in the mammary glands, which in most cases in Ukraine are interpreted as “mastopathy”, require a revision of the concept of the problem. Non-neoplastic changes in the mammary glands are most often represented by different variants of the so-called aberration of normal development and involution, which are not pathological, but, according to some signs, are those that are close to pathology, but are considered as a variant of the norm. The diagnosis should be changed to a specified variant of the aberration.The article raises problems about the difficulty of distinguishing between normal and pathological condition, considers the main positions of diagnosis and treatment of fibrocystic changes of the mammary glands, gynecological diseases that are accompanied by this pathology, and genetic prerequisites. Detailed characteristics of the main components of herbal preparations used for the treatment of mammary gland hyperplasia are also presented.Changing the interpretation of the term “fibrocystic mastopathy” to the term “fibro-cystic changes” helps to revise views on the need for therapeutic measures, since the diagnosis “mastopathy” automatically prompts therapy, while the term “changes” primarily indicates the need drawing attention to the problem, correction of lifestyle, nutrition, etc., dynamic supervision and only for diagnosing fibrocystic disease – resolving the issue of treatment.

show abstract

Herbal Ingredients in the Prevention of Breast Cancer: Comprehensive Review of Potential Molecular Targets and Role of Natural Products

Cited by 8 publications

References 237 publications

In silico design of novel bioactive molecules to treat breast cancer with chlorogenic acid derivatives: a computational and SAR approach

In silico design of novel bioactive molecules to treat breast cancer with chlorogenic acid derivatives: a computational and SAR approach

Navigating breast cancer complexity: Deciphering the cross talk of Wnt/β catenin and Notch pathways in development and diseases

Fibrocystic changes of the mammary glands: interpretation of the diagnosis, issues of diagnosis and treatment (Literature review)

Contact Info

Product

Resources

About