Navigating breast cancer complexity: Deciphering the cross talk of Wnt/β catenin and Notch pathways in development and diseases
Iqra Rasool,
Aashiq Hussain Bhat,
Nuzhat Khurshid
et al.
Abstract:This study investigates miRNA impact on lung, colorectal, and epithelial
cancers, emphasizing Wnt3’s role in breast tumor growth through WNT
signaling and its influence on mammary stem cells. WNT pathway
inactivation induces drug-insensitive, quiescent states in breast cancer
stem cells, resulting in resistance to multiple drugs.
Tamoxifen-resistant breast carcinoma cells activate both canonical and
noncanonical WNT signaling, with Wnt3a enhancing tamoxifen resistance in
ER+ carcinoma cells. The study also exp… Show more
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