Herbal Essential Oil use as Ulcer Protective Activity: A Systematic Review

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One of the most common causes of permanent vision loss is glaucoma. Damage to the optic nerve and retinal ganglion cells, the root cause of visual field impairment, is typically the result of elevated intraocular pressure. Some patients' illness worsens even when treated with eye medications that reduce intraocular pressure. The pathophysiology of glaucoma is not only thought to involve mechanical and vascular dysfunctions of the eye, but also oxidative stress, neuroinflammation, and excitotoxicity. Therefore, natural compounds with antioxidant and anti-inflammatory qualities may offer a different strategy for treating glaucoma. This review summarizes the most up-to-date preclinical and clinical research on natural compounds that have been proven to contain neuroprotective characteristics for retinal ganglion cells and, consequently, may be useful in the treatment of glaucoma. Baicalein, forskolin, marijuana, ginsenoside, resveratrol, and hesperidin are all effective at lowering intraocular pressure. On the other hand, antioxidant, anti-inflammatory, and anti-apoptosis mechanisms are among those through which Ginkgo biloba, More research is needed to determine whether natural items can be used as a safe and effective treatment for glaucoma.

Section: Microglia and Astrogliamentioning

confidence: 99%

Recent Approaches of Ocular Disease and Its Herbal Product Treatment: An Updates

Butola¹,

Bisht²,

Kumar³

2023

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“…Homogeneous matrices, drug-enriched cores, and drug-enriched shells are all possible methods of drug incorporation into SLNs. Dependent on lipid content, pH, temperature, and the drug entrapment model, release occurs through particle biodegradation by lipases, erosion, or diffusion [44]. Because of their lengthy shelf life, increased stability, and controlled release of drugs, SLNs are a promising drug carrier [45].…”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Recent Advancement in Self Emulsifing Drug Delivery System

Bist

Faruk

2023

Every day, researchers make new attempts to identify neurotherapeutics, but few of them make it to clinical trials. The main cause is their low bioavailability, which is connected to low water solubility, low permeability through biological membranes, and the hepatic first-pass metabolism. However, the most significant challenge in administering drugs to the brain is overcoming the blood-brain barrier. In order to get around it, intranasal administration has become more popular, sometimes even more so than oral administration. Because of its structure, the nasal cavity can bypass the blood-brain barrier and transport drugs to the brain directly. Nasal absorption increases the systemic bioavailability of highly processed substances because they bypass the hepatic first-pass metabolism. However, due to their unique physicochemical properties, most neurotherapeutics must be synthesized in lipidic nanosystems as self-emulsifying drug delivery systems (SEDDS). To load large quantities of lipophilic medicines into micro or nanoemulsions, these isotropic mixes of oils, surfactants, and co-surfactants are diluted in water. The goal of SEDDS is to increase the stability of labile pharmaceuticals against enzymatic activity, boost drug penetration through absorptive membranes, and reduce the likelihood of drug precipitation at absorption sites. Therefore, improved brain targeting and bioavailability of medications might be anticipated by combining the benefits of SEDDS with those of the intranasal route for brain delivery. In order to better understand the mechanisms involved in the intranasal administration of pharmaceuticals loaded in SEDDS, this paper provides a comprehensive characterization of SEDDS as a lipidic nanosystem. Finally, the in vivo effects of intranasal or oral delivery of SEDDS, showing their superiority over standard solutions or suspensions, are described.

“…The giant cosmetic companies that generate billions of dollars of revenue annually [20] were founded in the twentieth century by chemists and pharmacists in the United States. A well-known cosmetic company started by selling books door-to-door, along with colognes manufactured by a friendly pharmacist [21]. After the First World War, the athletic look became fashionable for the first time, and the fashion statements made by Coco Channel, including dark eyes, red lipstick, red nail polish and suntanned skin, which became popular as a contrast to then dominant fad for pale skin [22].…”

Section: History Of Herbal Care Product For Skinmentioning

confidence: 99%

Past and Current Prospectives of Herbal Product for Skin Care

Prajapati¹,

Sagar²,

Kumar³

2022

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The treatment of skin ageing is vital in controlling numerous skin problems, especially in the elderly, which is a welcome side effect. Consumer demand for non-invasive products with fewer harmful effects than those currently on the market has led to a rapid surge in the development of new dermocosmetics. Herbal-derived formulations and natural compounds from plants have gained popularity because to the wide range of effective, non-toxic active ingredients they contain, many of which target different parts of the skin's ageing signalling pathways. The purpose of this review was, therefore, to identify the most current developments in the study of herbal-derived products, such as herbal formulations and isolated components with skin anti-aging effects. Clinical trials with available pharmacodynamics data support the protective effects of herbal-derived products used to treat, prevent, or control the ageing of human skin, and these investigations assessed the biological effects of these products in in vitro, ex vivo, and in vivo settings.