Herbal Dietary Supplements for Erectile Dysfunction: A Systematic Review and Meta-Analysis

Borrelli, Francesca; Colalto, Cristiano; Delfino, Domenico Vittorio; Izzo, Angelo A.

doi:10.1007/s40265-018-0897-3

Cited by 34 publications

(27 citation statements)

References 74 publications

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“…This is the first report that provides basic mechanistic information concerning CEO and CA-induced dose-dependent relaxation in human and rat CC. The major findings of the present study show that (1) CEO and CA relax human and rat CC in a concentration-dependent manner; (2) NO-cyclic guanosine monophosphate (cGMP) pathway is not involved in the relaxation response to CEO and CA; and (3) CEO and CA improve in vivo erectile function in diabetic rats.…”

Section: Discussionmentioning

confidence: 66%

“…In the current treatment for ED, phosphodiesterase-5 inhibitors (PDE-5i) are considered the first-line therapy (1). Plant-derived products have been used for the management of ED for a long time, and over 15% of men use natural-based therapies (2). Yohimbine, Korean ginseng, and ginkgo are popular examples used as male sexual performance enhancers in traditional medicine (3).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, a clinical trial showed the positive effects of ginseng on IIEF-5 scores compared with placebo. The treatment with ginseng was effective in four of the five IIEF-15 domains (2). Another study indicated that four weeks of daily treatment with high-dose Ginkgo biloba extract significantly increased erectile function in comparison with the vehicle-only treatment (6).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum

et al. 2019

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Cinnamomum cassia (Cinnamon) is a well-known traditional medicine with therapeutic benefits for centuries. We evaluated the effects of cinnamon essential oil (CEO) and its main component cinnamaldehyde (CA) on human corpus cavernosum (HCC) and rat CC. The essential oil of cinnamon was analyzed for the confirmation of the oil profile. HCC specimens from patients undergoing penile prosthesis surgery (age 48-69 years) were utilized for functional studies. In addition, erectile responses in anesthetized control and diabetic rats were evaluated in vivo after intracavernosal injection of CEO and CA, and rat CC strips were placed in organ baths. After precontraction with phenylephrine (10µM), relaxant responses to CEO and CA were investigated. CA (96.9%) was found as the major component. The maximum relaxation responses to CEO and CA were 96.4±3.5% and 96.0±5.0% in HCC and 97.5±5.5% and 96.8±4.8% in rat CC, respectively. There was no difference between control and diabetic rats in relaxation responses to CEO and CA. The relaxant responses obtained with essential oil and CA were not attenuated in the presence of nitric oxide synthase (NOS) inhibitor, and soluble guanylate cyclase inhibitor (sGS) in CC. In vivo, erectile responses in diabetic rats were lower than in control rats, which was restored after intracavernosal injection of CEO and CA. CEO and CA improved erectile function and relaxation of isolated strips of rat CC and HCC by a NO/cGMP-independent mechanism. Further investigations are warranted to fully elucidate the restorative effects of CEO and CA on diabetic erectile dysfunction.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum

et al. 2019

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“…Ginseng is used to promote rejuvenation and longevity, for frailty and stress, weakness and fatigue, both mental and physical (Ogawa‐Ochiai & Kawasaki, ), and as supportive treatment for diabetes, cardiovascular disease and many others (Mancuso & Santangelo, ). Recently, a number of systematic reviews have critically evaluated the clinical evidence for and against the effectiveness of ginseng in a number of conditions, such as erectile dysfunction (Borrelli, Colalto, Delfino, Iriti, & Izzo, ), chronic fatigue (Arring, Millstine, Marks, & Nail, ), hypertension (Lee, Lim, Jun, Choi, & Lee, ), diabetes (Gui, Xu, Xu, & Yang, ), Alzheimer's disease (Wang et al, ) and as an ergogenic aid (Lee, Jung, & Lee, ).…”

Section: Ginseng‐targeted Extractsmentioning

confidence: 99%

Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

Williamson

Liu

Izzo

2020

British J Pharmacology

Self Cite

218

173

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The nutraceuticals market is vast, encompassing many different products with inconsistent levels of evidence available to support their use. This overview represents a Western perspective of the nutraceuticals market, with a brief comparison with that in China, as an illustration of how individual health supplements increase and decrease in popularity in regional terms. Recent changes in sales patterns, mainly taken from the US market, are summarized and a selection of five newer products, which have not been subject to extensive recent review are profiled: astaxanthin, a carotenoid found in red algae, seafood, salmon and trout, as an antioxidant; cannabidiol, a non‐euphoric marijuana ingredient used as mood enhancer and for painful/inflammatory conditions; modified extracts of ginseng used in new indications including dementia and space travel; monk fruit, a non‐sugar high intensity sweetener and nigella seed, a popular food ingredient and Asian medicine, which has experienced an extraordinary rise in sales recently. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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“…However, Kim et al [72] reported no benefit of Panax ginseng in a placebocontrolled trial that was based on the Watts Sexual Function questionnaire. Based on a meta-analysis of five clinical studies, Borrelli et al [73] also concluded that Panax ginseng significantly improved erectile function.…”

Section: Panax Ginsengmentioning

confidence: 99%

Alternative medicine and herbal remedies in the treatment of erectile dysfunction: A systematic review

Leisegang

Finelli

2021

Arab Journal of Urology

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Objectives: To systematically review and discuss the current evidence from placebo-controlled clinical trials that investigated the use of alternative medicines and herbal remedies in the management of erectile dysfunction (ED). Methods: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)based systematic review using specific keyword combinations was conducted on the PubMed and Scopus databases. Randomised controlled trials investigating herbal medicine in at least one group and using the International Index of Erectile Function (IIEF) as an outcome in patients primarily diagnosed with ED were included for review. Results: Following the literature search, screening and eligibility analysis, a total of 42 articles were included. The 42 articles were categorised as single herb extractions (n = 14), combination herbal formula (n = 5), combination of herbal formula and non-herbal nutraceuticals (n = 7), non-herbal nutraceuticals (n = 5), acupuncture and moxibustion (n = 2), diet and nutrition (n = 3), exercise (n = 5), and topical treatments (n = 1). Based on the results, Korean ginseng, Pygnogenol and Prelox, Tribulus terrestris, Lepidium meyenii, L-arginine, acupuncture and lifestyle interventions were the more predominantly investigated treatments interventions for ED. Conclusions: Panax ginseng, Pygnogenol, Prelox and Tribulus terrestris have promising evidence as herbal products, alongside L-arginine as a nutritional supplement, for ED based on IIEF outcomes, and warrant further clinical investigation. The mechanisms of action remain unclear, but each of these appears to in part increase nitric oxide synthesis. Importantly, improved diet and exercise should be considered, particularly in patients with obesity or diabetes mellitus.

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Herbal Dietary Supplements for Erectile Dysfunction: A Systematic Review and Meta-Analysis

Cited by 34 publications

References 74 publications

Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum

Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum

Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

Alternative medicine and herbal remedies in the treatment of erectile dysfunction: A systematic review

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