Herbal decoctosome is a novel form of medicine

Li, Xiaoyun; Zhu, Lei; Du, Jun; Wang, Zhiqing; Song, Moshi; Li, Zhiqing; Zhao, Yan; Zhao, Dandan; Ma, Yiming; Ye, Jun; Xu, Jiaming; Zhao, Yu; Chang, Jian; Qin, Yuhao; Yu, Lanlan; Wang, Chenxuan; Jiang, Chengyu

doi:10.1007/s11427-018-9508-0

Cited by 67 publications

(73 citation statements)

References 13 publications

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“…For example, the decoction of Hong Jing Tian (HJT, RHODIOLAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata ), can ameliorate the activation of TGF-β1-induced MRC-5 fibrotic cells and the pulmonary fibrosis in the bleomycin-induced mice ( Du et al, 2019 ). Subsequently, Li et al defined the heat-stable nanovesicles from HJT decoctions as decoctosomes (size: 198 nm) and reported that they possess more potent therapeutic effects in vitro and in vivo than the corresponding decoctions ( Li et al, 2019 ). A component analysis of HJT decoctosomes demonstrated that the specific sRNA HJT-sRNA-m7 exhibits potent anti-fibrosis effects.…”

Section: Application In Tissue Renewal and Remodelingmentioning

confidence: 99%

“…Plant-derived nanovesicles are a group of nano-scaled vesicles that are isolated from dietary vegetables and fruits ( Zhang et al, 2016b ; Yang et al, 2018a ; Li et al, 2019 ). These nanovesicles contain a broad range of membrane-bounded structures from distinct origins, including (1) natural extracellular vesicles (including exosomes) as well as intracellular vesicles existing in plants; (2) artificial vesicles formed during the preparation and extraction process; (3) synthetic liposomes or nanovectors prepared from plant-derived molecules as natural vesicle mimics.…”

Section: Introductionmentioning

confidence: 99%

“…Plant-derived nanovesicles possess high biocompatibility and promise a large-scale production. More and more evidences suggest that plant-derived nanovesicles can enter mammalian cells and mediate plant-animal cross-kingdom gene regulation, i.e., plant small RNAs packed by plant-derived nanovesicles could survive in the active form in animals and exogenously modulate the host cellular processes via genetic crosstalk ( Li et al, 2019 ). It indicates a potential medical application of plant-derived nanovesicles in the regulation of the fundamental biological processes in the human body.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, plant-derived nanovesicles have exhibited promising activities in the homeostatic regulation of the immune system, development of tissue engineering and reconstruction, delivery of chemotherapeutic drugs and nucleic acids, etc. ( Ju et al, 2013 ; Quesenberry et al, 2015 ; Zhang et al, 2016a,b,c ; Yang et al, 2018a ; Li et al, 2019 ). In addition, compared to the currently available drug delivery systems, plant-derived nanovesicles have multiple advantages, such as low immunogenicity and stability in the gastrointestinal tract ( Yang et al, 2018a ).…”

Section: Introductionmentioning

confidence: 99%

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Plant-Derived Nanovesicles: A Novel Form of Nanomedicine

Deng

Liu

et al. 2020

Front. Bioeng. Biotechnol.

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The nanovesicles extracted from the plant and herbal decoctions are identified as a new class of nanomedicine. They are involved in interspecies chemical communication across the plant and animal kingdoms and display a therapeutic potential against a variety of diseases. Herein, we review the recent progress made in the medical applications of plant-derived nanovesicles in the aspects of anti-inflammation, anti-cancer, tissue regeneration, and modulating commensal microbiota. We further summarize the cellular and molecular mechanisms underlying the physiological functions of plant-derived nanovesicles. Overall, plant-derived nanovesicles provide an alternative to conventional synthetic drugs and present exciting opportunities for future research on disease therapy.

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Section: Application In Tissue Renewal and Remodelingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Plant-Derived Nanovesicles: A Novel Form of Nanomedicine

Deng

Liu

et al. 2020

Front. Bioeng. Biotechnol.

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“…In this special topic "Herbal small RNAs, novel precision medicine from Mother Nature", we present four original articles that study the entry of small RNAs derived from herbs used in traditional Chinese medicine into mammalian cells and their function within human and mouse cells, and one review paper focusing on current trends in herb genomics (Du et al, 2017;Huang et al, 2018;Zhang et al, 2018;Li et al, 2019;Xin et al, 2018).…”

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confidence: 99%

From herbal small RNAs to one medicine

Kriaucionis

Kessler

et al. 2019

Sci. China Life Sci.

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Plant‐Derived Vesicle‐Like Nanoparticles as Promising Biotherapeutic Tools: Present and Future

et al. 2023

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At present, it is generally acknowledged that EVs are secreted by almost all living cells including plant cells. [4] Compared with mammalian EVs, the research of plant EVs is still in its infancy. Increasing evidence has proved that plant cells are able to secret exosome-like vesicles or extracellular vesicles into apoplast space. [5] In the 1960s, using transmission electron microscopy (TEM), Halperin et al. for the first time observed and discovered multivesicular bodies (MVBs) fusing with the plasma membrane and releasing exosome-like vesicles into the cell wall area in carrot cell cultures. [6] Fifty years after this first discovery, Regenteet al. used a tissue-infiltration-centrifugation method and successfully separated exosome-like vesicles from apoplast washing fluids (AWF) of sunflower seeds. [5a] Following these discoveries, plant exosomelike vesicles or vesicle-like nanoparticles have been successfully isolated from many plant species, including ginseng, ginger, broccoli, bitter melon, oat, grape, grapefruit, lemon, blueberry, orange, sunflower seed, and Arabidopsis, etc. [5a,7] The efficient separation of PDVLNs from plant cells is still one of the challenges that need to be solved in the plant EV field. At present, two plant tissue pre-processing methods, namely tissue-disruption and tissue-infiltration centrifugation, have emerged as favorite methods used for vesicle separation from plant cells in the field. [5b,8] After tissue pre-treatment, most studies use ultracentrifugation or density gradient centrifugation for further PDVLN separation. [5a,9] In addition, novel separation methods are under development for PDVLNs, such as ultrafiltration, immunoaffinity capture, size-exclusive chromatography, etc. [5b,7j,10] However, it is still challenging to isolate specific PDVLN subtypes, due to the lack of generic or specific markers for PDVLNs and well-verified plant species antibodies. [4b,5b] The nomenclature of vesicles prepared by these methods is not standardized in existing references. Many terms were used, including "plant particles", "plant vesicles", etc. [7b,8b,10,11] To facilitate communication in the plant vesicle field, standardizing the nomenclatures is necessary. We thus propose to unify these nomenclatures into plant-derived vesicle-like nanoparticles (PDVLNs) in this review.PDVLNs share many similar physical characteristics to those of human-derived EVs, including features such as morphology, particle size, concentration, Zeta potential, etc. [2a,7b,e,11] To further elucidate the specific molecular mechanism of PDVLNs on Extracellular vesicles (EVs) are heterogeneous, phospholipid bilayer-enclosed biological particles that regulate cell communication by molecular cargo delivery and surface signaling. EVs are secreted by almost all living cells, including plant cells. Plant-derived vesicle-like nanoparticles (PDVLNs) is a generic term referring to vesicle-like nanostructure particles isolated from plants. Their low immunogenicity and wide availability make PDVLNs safer and mor...

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Herbal decoctosome is a novel form of medicine

Cited by 67 publications

References 13 publications

Plant-Derived Nanovesicles: A Novel Form of Nanomedicine

Plant-Derived Nanovesicles: A Novel Form of Nanomedicine

From herbal small RNAs to one medicine

Plant‐Derived Vesicle‐Like Nanoparticles as Promising Biotherapeutic Tools: Present and Future

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