Herbal cardiotonic pills prevent gut ischemia/reperfusion-induced hepatic microvascular dysfunction in rats fed ethanol chronically

Horie, Yoshinori; Han, Jing; Mori, Shuka; Konishi, Masahiro; Kajihara, Mikio; Kaneko, Takehiko; Yamagishi, Yuka; Kato, Shinichi; Ishii, Hiromasa; Hibi, Toshifumi

doi:10.3748/wjg.v11.i4.511

Cited by 27 publications

(17 citation statements)

References 29 publications

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“…Several lines of data have accumulated so far in this field. To mention a few, for example, pretreatment with Cardiotonic Pills (CP, the major ingredients of which are DLA and SalB) attenuated the gut ischemia/reperfusion-induced leukocyte adhesion in the liver sinusoids and plasma TNF-α and endotoxin [16] , and diminished the thrombi induced by photochemical stimulation in rat mesenteric venules, as demonstrated in our previous study [17] . CP was reported to inhibit the expression of ICAM-1 and vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells [18] .…”

Section: Compound Danshen Injection Improves Endotoxin-induced Microcmentioning

confidence: 88%

Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery

Han

Horie²,

Miura³

et al. 2007

WJG

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stained with Monastral blue B, rolling and adhesion of leukocytes, production of oxygen radical in venular wall, albumin efflux and enhanced mast cell degranulation in vivo , all of which, except for the leukocyte rolling, were attenuated by the treatment with compound Danshen injection. Experiments performed in vitro further revealed that the expression of CD11b/CD18 and the production of oxygen free radical in neutrophils, and the expression of ICAM-1 in HUVECs were increased by exposure to LPS, and they were attenuated by compound Danshen injection. CONCLUSION: These results suggest that compoundDanshen injection is an efficient drug with multi-targeting potential for improving the microcirculatory disturbance. INTRODUCTIONIt is now well-recognized that stimulation with lipopolysaccharide (LPS) leads to a number of responses in microcirculation, such as endothelial cell damage, an increase in rolling, adhesion and emigration of leukocytes in post-capillary venules, enhanced oxygenfree radical production, mast cell degranulation and protein efflux [1][2][3][4][5][6] . Furthermore, it is demonstrated that LPS stimulation evokes an increase in the expression of adhesion molecules, including L-selectin [7] and CD11b/CD18 in leukocytes, E-selectin and intercellular adhesion molecule 1 (ICAM-1) in endothelial cells [7][8][9][10][11][12][13] . In addition, LPS stimulation can cause the release of proinflammatory mediators and vasoactive substances, such Abstract AIM: To investigate the effect of compound Danshen injection on lipopolysaccharide (LPS)-induced rat mesenteric microcirculatory dysfunctions and the underlying possible mechanism by an inverted intravital microscope and high-speed video camera system. METHODS:LPS was continuously infused through the jugular artery of male Wistar rats at the dose of 2 mg/kg per hour. Changes in mesenteric microcirculation, such as diameters of arterioles and venules, velocity of RBCs in venules, leukocyte rolling, adhesion and emigration, free radicals released from post-capillary venules, FITCalbumin leakage and mast cell degranulation, were observed through an inverted intravital microscope assisted with CCD camera and SIT camera. Meanwhile, the expression of adhesion molecules CD11b/CD18 and the production of free radical in neutrophils, and the expression of intercellular adhesion molecule 1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs) were quantified by flow cytometry (FACS) in vitro . RESULTS:The continuous infusion with LPS resulted in a number of responses in microcirculation, including a significant increase in the positive region of venule

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Section: Compound Danshen Injection Improves Endotoxin-induced Microcmentioning

confidence: 88%

Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery

Han

Horie²,

Miura³

et al. 2007

WJG

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“…Besides the I/R in- jury, an immunological mechanism should attribute to the further injury [18,19] . Antioxidant treatments have been used successfully to decrease reperfusion injury in multiple organ systems such as heart [20] , bowel [21] and liver [22] . Combined with detorsion, it has been reported that allopurinol [23] and superoxide dismutase plus catalase [2] treatment caused a signifi cant rescue of testes' function after testicular torsion.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Influence of Prepubertal Testicular Torsion on Spermatogenesis

Sun¹,

Liu²,

Zhao³

et al. 2006

Urol Int

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Purpose: To study the influence of prepubertal unilateral testicular torsion on spermatogenesis postpubertally. Methods: Sixty prepubertal SD male rats were divided into 6 groups. In each group, animal suffered different courses of unilateral testicular torsion including sham operation, 2- and 6-hour-long torsion, and permanent torsion. Salvia miltiorrhiza was injected as a remedy to release the I/R injury in the 2- and 6-hour-long torted groups. Postpubertally, the percentage of DNA content of haploid cells in the testes was determined individually. Results: The percentage of haploid cells in the sham operation group was 76.5 ± 1.9%. The number decreased in every other group (p < 0.01). Comparing with the same course of torsion, Salvia miltiorrhiza injection could improve the percentage of haploid cells (p < 0.01). In the permanent unilateral testicular torted group, the percentage was nearly zero (0.4 ± 0.2%). Conclusions: Prepubertal unilateral testicular torsion induces decreased spermatogenesis postpubertally. The result takes place in the bilateral testes. Salvia miltiorrhiza, as an antioxidant remedy, could relieve the injury which manifests improved spermatogenesis.

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“…A number of clinical and physiological effects of PNS have recently been described, such as improvement of myocardial dysfunction in rats with burn injuries (Zhang et al, 2003), amelioration of hepatic microcirculatory disturbances (Park et al, 2005), attenuation of LPS-induced adhesion of leukocytes to the venular wall and suppression of CD11b/CD18 expression in rat neutrophils (Sun et al, 2006), and improvement of endothelial cell function (Chen et al, 2004). Cardiotonic pills (CP, a traditional Chinese medicine which contains PN, salvia miltiorrhiza, and borneol), which use PNS as major ingredients, attenuate adhesion of leukocytes to hepatic sinusoids after ischemia-reperfusion (I/R) in rats chronically fed with ethanol, as demonstrated in our previous studies (Horie et al, 2005). In general, it can be said that the cellular and molecular events which underlie the biological activity of the major components of PNS have attracted much attention in the past few years.…”

Section: Introductionmentioning

confidence: 78%

Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery

et al. 2007

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Herbal cardiotonic pills prevent gut ischemia/reperfusion-induced hepatic microvascular dysfunction in rats fed ethanol chronically

Cited by 27 publications

References 29 publications

Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery

Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery

Long-Term Influence of Prepubertal Testicular Torsion on Spermatogenesis

Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery

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