Herb–drug pharmacokinetic interaction of artificial calculus bovis with diclofenac sodium and chlorpheniramine maleate in rats

Peng, Can; Lv, Mengying; Tian, Ji-Xin; Huang, Yin; Tian, Ye; Zhang, Zunjian

doi:10.1111/jphp.12069

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…CDCT is a classical herb–drug prescription for treating common cold. The main ingredients of CDCT were artificial calculus bovis, diclofenac sodium, and chlorphenamine (Peng et al, 2013, 2014). Clinical reports and previous studies also suggest that they are the main components causing adverse reactions in herb–drug medicines used for the treatment of colds.…”

Section: Discussionmentioning

confidence: 99%

“…Forty animals were randomly allocated to two groups, that is, control group (C, n = 10) and medicine group (M, n = 30, ACB 10 mg/Kg + DS 2 mg/Kg + CPM 10 mg/Kg). The dose of CDCT was selected according to the literature (Peng et al, 2013). Rats were executed intragastrically administered with CDCT of medicine group and control group with 0.5% CMC-Na once a day for 6 days.…”

Section: Animal Experiments and Samples Collectionmentioning

confidence: 99%

“…Compound diclofenac sodium chlorphenamine maleate tablets (CDCT), a typical herb‐durg medicine, one of the most commonly used for cold to relieve the complications of headache, fever, cough, and pharyngodynia, is mainly composed of artificial calculus bovis (ACB), diclofenac sodium (DS), and chlorphenamine (CPM) (Peng et al, 2013). However, China Food and Drug Administration (CFDA) issued a notice on “Warning of Hemorrhagic Adverse Reactions caused by Compound diclofenac sodium chlorphenamine maleate tablets,” reporting that there were 219 cases of hematuria and 2 cases of death (http://www.nmpa.gov.cn/WS04/CL2042/).…”

Section: Introductionmentioning

confidence: 99%

“…Research over the past few years has shown that ACB, DS, and CPM alone usage at usual therapeutical dosages have not caused hematuria or other adverse effect (Franceschi et al, 2016; Monte et al, 2010). Our previous pharmacokinetic data showed that co‐administration of ACB with DS and CPM could alter clearance, area under the concentration‐time curve, and so forth (Peng et al, 2013). Although the herb–drug interation has been identified, the occurrence and development of CDCT exposure in rat have not been evaluated yet, and the pharmacodynamic mechanism of CDCT exposure‐induced nephrotoxicity remains mostly unknown.…”

Section: Introductionmentioning

confidence: 99%

“…diclofenac sodium (DS), and chlorphenamine (CPM) (Peng et al, 2013). However, China Food and Drug Administration (CFDA) issued a notice on "Warning of Hemorrhagic Adverse Reactions caused by Compound diclofenac sodium chlorphenamine maleate tablets," reporting that there were 219 cases of hematuria and 2 cases of death (http://www.nmpa.gov.cn/WS04/CL2042/).…”

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CDCT‐induced nephrotoxicity in rat by apoptosis via metabolic disturbance

Zuo

Liu

Wang

et al. 2023

J of Applied Toxicology

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Compound diclofenac sodium chlorphenamine maleate tablets (CDCT) are widely used for the cold in Asia. However, CDCT can cause hematuria symptoms in clinical, and the underlying mechanism is unknown. This study aims to investigate the CDCT‐induced changes of morphology in kidney and metabolites and further explore the possible mechanisms of CDCT‐induced nephrotoxicity. Sprague–Dawley rats were exposed to the CDCT at a clinical equivalent dose for 6 days. CDCT exposure can induce kidney injury and death. Pathological changes, including creatinine, urea nitrogen, and histopathology, were observed in rats. Furthermore, metabolomic‐driven energy and glycerophospholipid metabolism pathway disorders, accompanied by remarkably changed key metabolites, such as succinate, leukotriene B4 (LTB4), and cardiolipin (CL), are observed in the CDCT‐induced nephrotoxicity. Functionally, succinate accumulation leads to mitochondrial damage, as evidence by the imbalance of complex I and complex II and an increase in mitochondrial reactive oxygen species (mito SOX). Meanwhile, LTB4 activated the NF‐κB signaling, as shown by increased protein of p65, phosphor‐p65, and decreased protein of IκBα and phosphor‐IκBα. Eventually, the apoptosis pathway was triggered in response to reduced CL, inflammation, and mito SOX, as demonstrated by the expression of cyt c, Bax, Bcl‐2, caspase‐3, and caspase‐9. This study indicated that CDCT‐induced metabolic disorders triggered nephrotoxicity and provided a comprehensive information to elucidate the mechanism of CDCT induced nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Animal Experiments and Samples Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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CDCT‐induced nephrotoxicity in rat by apoptosis via metabolic disturbance

Zuo

Liu

Wang

et al. 2023

J of Applied Toxicology

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Development of a sensitive and rapid UHPLC–MS/MS method for simultaneous quantification of nine compounds in rat plasma and application in a comparative pharmacokinetic study after oral administration of Xuefu Zhuyu Decoction and nimodipine

Zhang

et al. 2020

Biomedical Chromatography

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Xuefu Zhuyu Decoction (XFZYD) is a traditional Chinese medicine prescription used for the clinical treatment of traumatic brain injury (TBI). The purpose of this work was to develop a sensitive and rapid UHPLC–MS/MS method to simultaneously study the pharmacokinetics of nimodipine and eight components of XFZYD, namely, amygdalin, hydroxysafflor yellow A, rutin, liquiritin, narirutin, naringin, neohesperidin and saikosaponin A, in rats with and without TBI. Multiple reaction monitoring was highly selective in the detection of nine analytes and the internal standard without obvious interference. The calibration curves displayed good linearity (r > 0.99) over a wide concentration range. The mean absolute recoveries of the nine analytes were 85–106%, and all matrix effects were in the range 80–120%. The intra‐ and inter‐day precision and accuracy were acceptable (RSD, <15%; RE%, ±20%). The validated method was successfully applied to compare the pharmacokinetics in four experimental groups, including control rats orally administered XFZYD and TBI model rats orally administered XFZYD, XFZYD and nimodipine, or nimodipine alone. The results showed that herb–drug interactions occurred between XFZYD and nimodipine in the treatment of TBI, nimodipine affected the pharmacokinetics of XFZYD, and XFZYD affected the absorption, distribution and excretion of nimodipine in vivo.

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Herb-drug enzyme-mediated interactions and the associated experimental methods: a review

Zhao

Yang

et al. 2016

Journal of Traditional Chinese Medicine

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Herb–drug pharmacokinetic interaction of artificial calculus bovis with diclofenac sodium and chlorpheniramine maleate in rats

Abstract: This study indicated that co-administration of ACB with DS and CPM can result in an apparent herb-drug pharmacokinetic interaction in rats.

Cited by 5 publications

References 36 publications

CDCT‐induced nephrotoxicity in rat by apoptosis via metabolic disturbance

CDCT‐induced nephrotoxicity in rat by apoptosis via metabolic disturbance

Development of a sensitive and rapid UHPLC–MS/MS method for simultaneous quantification of nine compounds in rat plasma and application in a comparative pharmacokinetic study after oral administration of Xuefu Zhuyu Decoction and nimodipine

Herb-drug enzyme-mediated interactions and the associated experimental methods: a review

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