Herb-drug enzyme-mediated interactions and the associated experimental methods: a review

Li, Bo; Zhao, Baosheng; Yang, Liu; Tang, Mingmin; Beiran, Lüe; Luo, Zhiqiang; Zhai, Huaqiang

doi:10.1016/s0254-6272(16)30054-1

Cited by 18 publications

(12 citation statements)

References 103 publications

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“…Co‐medication with herbs can result in changes in pharmacological effects of many drugs (Bo et al, ). T. mongolicum decoction was able to synergize with trimethoprim (TMP); the most active combination was 2.5 g dandelion and 10 mg TMP (Zhu, ).…”

Section: Antibacterial Activity Of the Genus Taraxacummentioning

confidence: 99%

Ethnobotany of the genus Taraxacum—Phytochemicals and antimicrobial activity

Sharifi‐Rad

Roberts

Matthews

et al. 2018

Phytotherapy Research

104

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Plants belonging to the genus Taraxacum have been used in traditional healthcare to treat infectious diseases including food-borne infections. This review aims to summarize the available information on Taraxacum spp., focusing on plant cultivation, ethnomedicinal uses, bioactive phytochemicals, and antimicrobial properties. Phytochemicals present in Taraxacum spp. include sesquiterpene lactones, such as taraxacin, mongolicumin B, and taraxinic acid derivatives; triterpenoids, such as taraxasterol, taraxerol, and officinatrione; and phenolic derivatives, such as hydroxycinnamic acids (chlorogenic, chicoric, and caffeoyltartaric acids), coumarins (aesculin and cichoriin), lignans (mongolicumin A), and taraxacosides. Aqueous and organic extracts of different plant parts exhibit promising in vitro antimicrobial activity relevant for controlling fungi and Gram-positive and Gram-negative bacteria. Therefore, this genus represents a potential source of bioactive phytochemicals with broad-spectrum antimicrobial activity. However, so far, preclinical evidence for these activities has not been fully substantiated by clinical studies. Indeed, clinical evidence for the activity of Taraxacum bioactive compounds is still scant, at least for infectious diseases, and there is limited information on oral bioavailability, pharmacological activities, and safety of Taraxacum products in humans, though their traditional uses would suggest that these plants are safe.

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Section: Antibacterial Activity Of the Genus Taraxacummentioning

confidence: 99%

Ethnobotany of the genus Taraxacum—Phytochemicals and antimicrobial activity

Sharifi‐Rad

Roberts

Matthews

et al. 2018

Phytotherapy Research

104

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“…Most interactions of herbal medicine and Western medicine mainly appeared by affecting the emergence of cytochrome P450, UDP-glucuronosyl transferase (UGT), or drug transport protein [ 18 , 19 ]. Herbal medicine can inhibit or induce these enzymes or protein to increase or decrease the medical concentration in blood, viscera, urine, or bile and proceed to cause the change of pharmacokinetic parameters and lead to ineffective treatment of the medicine or potential adverse reactions.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic Interaction Study of Ketamine and Rhynchophylline in Rat Plasma by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry

Chen

You

Chen

et al. 2018

BioMed Research International

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Eighteen Sprague-Dawley rats were randomly divided into three groups: ketamine group, rhynchophylline group, and ketamine combined with rhynchophylline group (n = 6). The rats of two groups received a single intraperitoneal administration of 30 mg/kg ketamine and 30 mg/kg rhynchophylline, respectively, and the third group received combined intraperitoneal administration of 30 mg/kg ketamine and 30 mg/kg rhynchophylline together. After blood sampling at different time points and processing, the concentrations of ketamine and rhynchophylline in rat plasma were determined by the established ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method. Chromatographic separation was achieved using a UPLC BEH C18 column (2.1 mm × 50 mm, 1.7 μm) with carbamazepine as an internal standard (IS). The initial mobile phase consisted of acetonitrile and water (containing 0.1% formic acid) with gradient elution. Multiple reaction monitoring (MRM) modes of m/z 238.1 → 179.1 for ketamine, m/z 385.3 → 159.8 for rhynchophylline, and m/z 237.3 → 194.3 for carbamazepine (IS) were utilized to conduct quantitative analysis. Calibration curve of ketamine and rhynchophylline in rat plasma demonstrated good linearity in the range of 1-1000 ng/mL (r > 0.995), and the lower limit of quantification (LLOQ) was 1 ng/mL. Moreover, the intra- and interday precision relative standard deviation (RSD) of ketamine and rhynchophylline were less than 11% and 14%, respectively. This sensitive, rapid, and selective UPLC-MS/MS method was successfully applied to pharmacokinetic interaction study of ketamine and rhynchophylline after intraperitoneal administration. The results showed that there may be a reciprocal inhibition between ketamine and rhynchophylline.

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“…Drug-food interactions can result from the interaction of drugs with some natural constituents such as alkaloids and flavonoids, as well as other artificial components which are present in daily consumed food and drinks (Bansal et al, 2009;Li et al, 2016;Li, Revalde & Paxton, 2017;Abdallah et al, 2015;Kamenickova & Dvorak, 2012). Alteration in CYP enzymes and ABC can consequently alter the PK parameters of their substrates, i.e., bioavailability, tissue penetration, biliary excretion with a possible occurrence of drugrelated toxicities (Bansal et al, 2009;Li et al, 2016;Li, Revalde & Paxton, 2017;Abdallah et al, 2015). Fruits and vegetables are known to be rich sources of bioactive flavonoids which can have different inhibitory effects on CYP450 metabolizing enzymes such as CYP3A4 and transporter proteins including P-gp (Bansal et al, 2009;Li et al, 2016;Li, Revalde & Paxton, 2017;Abdallah et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Alteration in CYP enzymes and ABC can consequently alter the PK parameters of their substrates, i.e., bioavailability, tissue penetration, biliary excretion with a possible occurrence of drugrelated toxicities (Bansal et al, 2009;Li et al, 2016;Li, Revalde & Paxton, 2017;Abdallah et al, 2015). Fruits and vegetables are known to be rich sources of bioactive flavonoids which can have different inhibitory effects on CYP450 metabolizing enzymes such as CYP3A4 and transporter proteins including P-gp (Bansal et al, 2009;Li et al, 2016;Li, Revalde & Paxton, 2017;Abdallah et al, 2015). The inhibition of P-gp by flavonoids can be comparable to that by verapamil and cyclosporine, two very well-known P-gp inhibitors (Bansal et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Flavoured water consumption alters pharmacokinetic parameters and increases exposure of erlotinib and gefitinib in a preclinical study using Wistar rats

Almomen

Maher

Alzoman

et al. 2020

PeerJ

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Background Erlotinib (ERL) and Gefitinib (GEF) are considered first line therapy for the management of non-small cell lung carcinoma (NSCLC). Like other tyrosine kinase inhibitors (TKIs), ERL and GEF are mainly metabolized by the cytochrome P450 (CYP450) CYP3A4 isoform and are substrates for transporter proteins with marked inter-/intra-individual pharmacokinetic (PK) variability. Therefore, ERL and GEF are candidates for drug-drug and food-drug interactions with a consequent effect on drug exposure and/or drug-related toxicities. In recent years, the consumption of flavoured water (FW) has gained in popularity. Among multiple ingredients, fruit extracts, which might constitute bioactive flavonoids, can possess an inhibitory effect on the CYP450 enzymes or transporter proteins. Therefore, in this study we investigated the effects of different types of FW on the PK parameters of ERL and GEF in Wistar rats. Methods ERL and GEF PK parameters in different groups of rats after four weeks consumption of different flavours of FW, namely berry, peach, lime, and pineapple, were determined from plasma drug concentrations using ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS). Results Data indicated that tested FWs altered the PK parameters of both ERL and GEF differently. Lime water had the highest impact on most of ERL and GEF PK parameters, with a significant increase in Cmax (95% for ERL, 58% for GEF), AUC0–48 (111% for ERL, 203% for GEF), and AUC0–∞ (200% for ERL, 203% for GEF), along with a significant decrease in the apparent oral clearance of both drugs (65% for ERL, 67% for GEF). The order by which FW affected the PK parameters for ERL and GEF was as follows: lime > pineapple > berry > peach. Conclusion The present study indicates that drinking FW could be of significance in rats receiving ERL or GEF. Our results indicate that the alteration in PKs was mostly recorded with lime, resulting in an enhanced bioavailability, and reduced apparent oral clearance of the drugs. Peach FW had a minimum effect on the PK parameters of ERL and no significant effect on GEF PKs. Accordingly, it might be of clinical importance to evaluate the PK parameters of ERL and GEF in human subjects who consume FW while receiving therapy.

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Herb-drug enzyme-mediated interactions and the associated experimental methods: a review

Cited by 18 publications

References 103 publications

Ethnobotany of the genus Taraxacum—Phytochemicals and antimicrobial activity

Ethnobotany of the genus Taraxacum—Phytochemicals and antimicrobial activity

Pharmacokinetic Interaction Study of Ketamine and Rhynchophylline in Rat Plasma by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry

Flavoured water consumption alters pharmacokinetic parameters and increases exposure of erlotinib and gefitinib in a preclinical study using Wistar rats

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