HER-2/
            <i>neu</i>
            Expression in Prostate Adenocarcinoma: A Systematic Review and Meta-Analysis

Neto, Ary Serpa; Tobias-Machado, Marcos; Wroclawski, Marcelo Langer; Fonseca, Fernando Luiz Affonso; Teixeira, Gabriel Kushiyama; Amarante, Rodrigo Dal Moro; Wroclawski, Eric Roger; Giglio, Auro del

doi:10.1016/j.juro.2010.04.077

Cited by 43 publications

(31 citation statements)

References 21 publications

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“…There was no association with the Gleason score or pathological stage, which is similar to some reports (Lara et al, 2002;Zahir et al, 2014). However other studies have reported an association with the Gleason score, HER-2 expression being higher in patients with a Gleason score >7 (Neto et al, 2010).…”

Section: Discussionsupporting

confidence: 89%

“…There is a suggestion that HER-2 may have a role in prostate cancer development, however its expression is variable, ranging between 0 to 100% depending on the HER-2 assay used (Ratan et al, 2003) and gene amplification of the HER-2 gene ranges from 0 to 53% (Liu et al, 2001;Montironi et al, 2006). Despite this discrepancy, there is still a consistent association between HER-2 over expression and a higher risk tumor recurrence and death in men with prostate cancer according to a meta-analysis (Neto et al, 2010). Secondary CPCs are associated with a seven fold increase of biochemical failure after radical prostatectomy and CPC detection using standard immunocytochemisty is able to identify a high risk group for biochemical failure before there is a rise in the serum PSA (Murray et al, 2013).…”

Section: Possible Role Of Her-2 In the Progression Of Prostate Cancermentioning

confidence: 99%

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Possible Role of HER-2 in the Progression of Prostate Cancer from Primary Tumor to Androgen Independence

Murray

Reyes²,

Fuentealba³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 89%

Section: Possible Role Of Her-2 In the Progression Of Prostate Cancermentioning

confidence: 99%

Possible Role of HER-2 in the Progression of Prostate Cancer from Primary Tumor to Androgen Independence

Murray

Reyes²,

Fuentealba³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…HER-2/neu is overexpressed in a wide variety of human malignancies, such as breast, ovary, prostate, lung, kidney and liver cancer, as well as osteosarcoma. Meta-analyses have shown that overexpression of HER-2/neu is associated with poor prognosis of breast, gastric, ovarian, prostate and lung cancer, but not osteosarcoma (Meert et al, 2003;de Graeff et al, 2009;Li and Geng, 2010;Neto et al, 2010;Harris et al, 2011;Wang et al, 2011). The prognostic value of HER-2/neu for CRC is still inconclusive.…”

Section: Introductionmentioning

confidence: 99%

Lack of Effects of HER-2/neu on Prognosis in Colorectal Cancer: a Meta-analysis

Han

Meng²,

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The prognostic value of human epidermal growth factor receptor-2 (HER-2/neu) for survival of patients with colorectal cancer (CRC) is still ambiguous. We therefore performed a meta-analysis to evaluate its prognostic significance. Materials and Methods: We searched the MEDLINE and EMBASE databases for published literature investigating associations between HER-2/neu status and overall survival of patients with CRC. A meta-analysis was performed using a DerSimonian-Laird model and publication bias was investigated by Begg's and Egger's tests. Subgroup analysis was also conducted according to the study design type, study quality score, cut-off value for HER-2/neu overexpression, publication region, patient number and publication year. Results: A total of 17 eligible studies involving 2,347 patients were identified for this meta-analysis. The combined hazard ratio (HR) was 1.31 (95% confidence interval (

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“…Our group (Serpa Neto et al, 2010) investigated the prognostic impact of HER2 over expression in patients with prostate cancer and its correlation with other pathological and clinical variables. We found a consistent association of HER2 over expression with death and recurrence.…”

Section: Correlation Between Immunohistochemistry and Histopathologicmentioning

confidence: 99%

E-Cadherin, beta-catenin and HER2 expression in prostate cancer tissues with perineural invasion and their correlation with Gleason score: A preliminary study

Rafael¹,

Maylla²,

Sandra³

et al. 2014

Afr. J. Pharm. Pharmacol.

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Prostate cancer (PC) is the most common malignant tumor in men. Early identification of prostate cancer may result in improved cure rates and increased life expectancies. Gleason score and clinical range at the time of diagnosis are important factors to predict prognosis and outcome after therapy but additional accurate and reliable biomarkers are warranted. Few biomarkers of prostate cancer have been successfully implemented and used in clinical practice. In this study, we sought to determine the expression of E-cadherin, beta-catenin and human epidermal receptor (HER2) in biopsy specimens of prostate cancer with perineural invasion, and correlate them with Gleason score in order to verify the relationship between those markers and prostate cancer process. Our study demonstrated abnormal expression of E-cadherin, beta-catenin and HER2. On the other hand, our results showed no correlation between Gleason score and the expression of those markers in invasive prostate cancer tissues. Other different biomarkers remain to be identified, that potentially could improve the evaluation of prognostic of the patient.

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HER-2/ neu Expression in Prostate Adenocarcinoma: A Systematic Review and Meta-Analysis

Cited by 43 publications

References 21 publications

Possible Role of HER-2 in the Progression of Prostate Cancer from Primary Tumor to Androgen Independence

Possible Role of HER-2 in the Progression of Prostate Cancer from Primary Tumor to Androgen Independence

Lack of Effects of HER-2/neu on Prognosis in Colorectal Cancer: a Meta-analysis

E-Cadherin, beta-catenin and HER2 expression in prostate cancer tissues with perineural invasion and their correlation with Gleason score: A preliminary study

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