1977
DOI: 10.1073/pnas.74.12.5707
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Heptadecapeptide gastrin in the vagal nerve.

Abstract: Immunoreactive gastrin was present in vagal nerves from cats, dogs, and human beings. The In cats electrical vagal stimulation causes a release of gastrin heptadecapeptide, which is atropin resistant (1-4). Recently a large number of peptides have been found to possess a dual localization to endocrine cells and neurons. Such peptides include substance P, vasoactive intestinal polypeptide (VIP), somatostatin, neurotensin, and cholecystokinin (5-12). Previous findings of gastrin immunoreactivity in the central… Show more

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Cited by 112 publications
(35 citation statements)
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“…In adult vertebrates, the primary site of gastrin synthesis is the antral G-cells in the stomach. However, gastrin peptides have also been detected in the small and large intestine [2], vagal nerve [3], ovary [4], testis [5], hypothalamus and pituitary gland [6]. Moreover, during fetal life, gastrin is expressed in the pancreas [7], and colorectal tissues [8].…”
Section: Introductionmentioning
confidence: 99%
“…In adult vertebrates, the primary site of gastrin synthesis is the antral G-cells in the stomach. However, gastrin peptides have also been detected in the small and large intestine [2], vagal nerve [3], ovary [4], testis [5], hypothalamus and pituitary gland [6]. Moreover, during fetal life, gastrin is expressed in the pancreas [7], and colorectal tissues [8].…”
Section: Introductionmentioning
confidence: 99%
“…The gastrin gene is expressed mainly in the antroduodenal G cells, and to a minor extent in the neonatal pancreas (12), vagal neurons (13), pituitary cells (14), and bronchial mucosal cells (15). In addition to I cells of the small intestine, the CCK gene is expressed in multiple central (16)(17)(18)(19) and peripheral neurons (20), in pituitary corticotrophs (21) and, as recently reported, in spermatogenic cells of several mammalian species (22,23).…”
Section: Introductionmentioning
confidence: 99%
“…Available, although indirect, evidence suggests that these forms reflect different steps in the posttranslational processing (7,8). Recently, gastrins have also been found in extraantral endocrine cells and neurons, in which, however, the processing differs from that of the antral cells (9)(10)(11)(12). In (3,200 Ci/mmol) were obtained from New England Nuclear.…”
mentioning
confidence: 99%