Hepcidin, interleukin-6 and hematological iron markers in males before and after heart surgery

Prohepcidin and Hepcidin in Acute Phase Reaction Accompanying Large Cardiac Surgery

“…In a homogenous group of uncomplicated cardiosurgical patients, significant correlation between hepcidin and IL-6 concentrations post-surgery was observed. Our results are in conformity with a recent study by Hoppe et al (2009). On a limited number of patients undergoing heart surgery, authors found significant alterations in both serum hepcidin and serum prohepcidin.…”

“…Prohepcidin decreased post-operatively. The decrease of prohepcidin after a heart surgery was firstly documented by Hoppe et al (2009). However there are some controversies between clinical findings and experimental studies.…”

Advance Targeted Transfusion in Anemic Cardiac Surgical Patients for Kidney Protection

“…23 This can occur if the ability of macrophages to sequester hemoglobin-iron is impaired, if macrophages are presented with an excessive amount of aged or damaged erythrocytes, or if the plasma transferrin concentration falls. 44 All of these events can occur in anemic patients undergoing cardiac surgery: 1) the ability of macrophages to sequester iron is promoted by the hormone hepcidin, which is inhibited in the setting of anemia 44 ; 2) the conduct of CPB causes substantial damage to erythrocytes, 46 increasing the burden on macrophages, and as shown in this study and by others, 47,48 reduces transferrin concentrations; and 3) CPB-induced hemodilution often necessitates the transfusion of 1 or more units of erythrocytes during surgery, which, as noted above, acutely presents a large number of damaged erythrocytes to the macrophages. As we did not measure free-iron levels in this study, we could not directly determine if transfusion-related free iron toxicity is a cause of postcardiac surgery AKI in anemic patients.…”

A hepcidina como parâmetro bioquímico na avaliação da anemia por deficiência de ferro

“…Hepcidin acts on the inhibition of intestinal iron absorption and iron release by macrophages and enterocytes 16,17 , and is a mediator in the cycle of iron absorption between the liver and intestine [22][23][24] .…”

“…Hepcidin has evolved as the primary regulator of iron homeostasis and a probable mediator of anemia of chronic disease and inflammation. This role has been widely demonstrated in a number of recent studies [14][15][16][17][18] , and there is enormous interest in quantifying circulating hepcidin levels in clinical samples 19 .…”